The Bile Acid Taurochenodeoxycholate Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1998 • 980 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

1999 • 537 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.

1998 • 454 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Fluid Shear Stress Stimulates Phosphorylation of Akt in Human Endothelial Cells

1998 • 420 citations

Inhibition of TNF-induced apoptosis by NF-κB

1998 • 370 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas

1999 • 316 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.

1994 • 270 citations

Apoptosis and hepatobiliary disease

1995 • 268 citations

The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway

1998 • 252 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Mechanism of Cholestasis

1972 • 209 citations

Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells

1999 • 192 citations

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

1998 • 192 citations

Dysregulation of Apoptosis as a Mechanism of Liver Disease: An Overview

1998 • 189 citations

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

1997 • 185 citations

Chemistry and Enterohepatic Circulation of Bile Acids

1984 • 166 citations

Positioning Atypical Protein Kinase C Isoforms in the UV-Induced Apoptotic Signaling Cascade

1997 • 164 citations

Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway.

1998 • 152 citations

The Role of Phosphoinositide 3-Kinase in Taurocholate-induced Trafficking of ATP-dependent Canalicular Transporters in Rat Liver

1998 • 131 citations

Cholestasis in Rats induced by Taurolithocholate

1966 • 129 citations

Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes

1996 • 82 citations

A Phosphatidylinositol 3-Kinase-dependent Pathway That Differentially Regulates c-Raf and A-Raf

1999 • 73 citations

Signal transduction and hepatocellular bile acid transport: Cross talk between bile acids and second messengers

1999 • 65 citations

Gi Proteins Use a Novel βγ- and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes

1999 • 52 citations

Reconstitution of bile acid transport in the rat hepatoma McArdle RH- 7777 cell line

1996 • 36 citations

Synthetic lipid products of PI3‐kinase which are added to culture medium prevent low K⁺‐induced apoptosis of cerebellar granule neurons via Akt kinase activation

1998 • 19 citations