The Point of No Return: Mitochondria, Caspases, and the Commitment to Cell Death

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Expression of baculovirus P35 prevents cell death in Drosophila

1994 • 1,037 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

1995 • 685 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

The role of DNA fragmentation in apoptosis

1995 • 608 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease.

1997 • 439 citations

grim, a novel cell death gene in Drosophila.

1996 • 414 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

Cell Killing by the Drosophila Gene reaper

1996 • 375 citations

The cell-death machine

1996 • 351 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

1994 • 288 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation?

1980 • 269 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

1997 • 251 citations

Die and Let Live: Eliminating Dangerous Lymphocytes

1996 • 242 citations

Bcl-2-independent Bcr–Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL

1998 • 238 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Cell death: programmed, apoptosis, necrosis, or other?

1995 • 220 citations

Pro‐oxidants and mitochondrial Ca²⁺: their relationship to apoptosis and oncogenesis

1993 • 218 citations

Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival.

1995 • 198 citations

Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases

1996 • 198 citations

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

1998 • 179 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

Heat shock induction of apoptosis in promastigotes of the unicellular organismLeishmania (Leishmania) amazonensis

1996 • 142 citations

Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro.

1996 • 138 citations

Caspase activity is required for commitment to Fas-mediated apoptosis

1997 • 132 citations

Collapse of the Inner Mitochondrial Transmembrane Potential Is Not Required for Apoptosis of HL60 Cells

1999 • 124 citations

Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers

1998 • 121 citations

The killer and the executioner: how apoptosis controls malignancy

1995 • 104 citations

Anti-apoptotic genes of baculoviruses.

1996 • 88 citations

DNA Digestion and Chromatin Condensation during Nuclear Death inTetrahymena

1996 • 66 citations

Thymic nurse cells: possible sites of T-cell selection

1986 • 57 citations

Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo.

1994 • 55 citations

PERSPECTIVE A UNITS‐OF‐EVOLUTION PERSPECTIVE ON THE ENDOSYMBIONT THEORY OF THE ORIGIN OF THE MITOCHONDRION

1995 • 45 citations

Changes in c-myc expression and the kinetics of dexamethasone-induced programmed cell death (apoptosis) in human lymphoid leukaemia cells

1994 • 29 citations

Perspective: A Units-of-Evolution Perspective on the Endosymbiont Theory of the Origin of the Mitochondrion

1995 • 20 citations