Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists?

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

[Biological psychiatry].

1980 • 1,087 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment

1981 • 645 citations

THE TREATMENT OF DEPRESSIVE STATES WITH G 22355 (IMIPRAMINE HYDROCHLORIDE)

1958 • 593 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

1985 • 581 citations

Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims

1986 • 552 citations

New concepts on the mechanism of action of benzodiazepines

1975 • 539 citations

Inhibition of Uptake of Tritiated-noradrenaline in the Intact Rat Brain by Imipramine and Structurally Related Compounds

1964 • 506 citations

Tritiated Imipramine Binding Sites Are Decreased in the Frontal Cortex of Suicides

1982 • 478 citations

Serotonin function in anxiety

1987 • 467 citations

Mechanism of Action of Benzodiazepines

1976 • 437 citations

DEPRESSION BY RESERPINE OF THE NORADRENALINE CONCENTRATION IN THE HYPOTHALAMUS OF THE CAT

1956 • 424 citations

5-HYDROXYINDOLE COMPOUNDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH PSYCHIATRIC OR NEUROLOGICAL DISEASES

1966 • 375 citations

Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat.

1978 • 336 citations

Serotonin Release as a Possible Mechanism of Reserpine Action

1955 • 336 citations

Effects of antidepressant drugs on different receptors in the brain

1981 • 325 citations

Typical and atypical antidepressants. Molecular mechanisms.

1982 • 315 citations

Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides

1984 • 301 citations

Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum

1974 • 289 citations

Learned helplessness and animal models of depression

1984 • 286 citations

Current Developments in Psychopharmacology

1981 • 275 citations

Neuropharmacology of Serotonin

1989 • 268 citations

Dopamine and depression: A review of recent evidence. I. Empirical studies

1983 • 267 citations

Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression

1977 • 264 citations

Neurochemical basis of the action of antidepressants on learned helplessness

1980 • 253 citations

Inhibition of the uptake of tritiated catecholamines by antidepressant and related agents

1967 • 252 citations

Specific tricyclic antidepressant binding sites in rat brain characterised by high-affinity 3H-imipramine binding

1980 • 249 citations

Current Developments in Psychopharmacology

1978 • 242 citations

Human platelets possess high-affinity binding sites for 3H-imipramine

1979 • 241 citations

ehavioural evidence for supersensitivtiy of postsynaptic dopamine receptors in the mesolimbic system after chronic administration of desipramine

1981 • 239 citations

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression

1987 • 230 citations

Modulation of receptor mechanisms in the CNS: Hyper-and hyposensitivity to catecholamines

1978 • 221 citations

m-Chlorophenylpiperazine: A central serotonin agonist causing powerful anorexia in rats

1979 • 221 citations

The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons

1971 • 220 citations

ACID MONOAMINE METABOLITES OF CEREBROSPINAL FLUID IN MENTAL DEPRESSION AND MANIA

1966 • 215 citations

British Journal of Clinical Pharmacology

2012 • 214 citations

Tianeptine, a selective enhancer of serotonin uptake in rat brain

1987 • 209 citations

Repeated tricyclics induce a progressive dopamine autoreceptor subsensitivity independent of daily drug treatment

1980 • 208 citations

5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants.

1985 • 198 citations

The Biochemical Basis of Neuropharmacology

1978 • 197 citations

Brain Adrenergic receptors and resistance to stress

1982 • 194 citations

Chronic treatment with antidepressants prevents the inhibitory effect of small doses of apomorphine on dopamine synthesis and motor activity

1979 • 193 citations

Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons

1982 • 188 citations

Human brain receptor alterations in suicide victims

1982 • 179 citations

Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: Subsensitivity without reduction in β-adrenergic receptor binding

1980 • 178 citations

Role of Serotonergic Input in the Regulation of the β-Adrenergic Receptor-Coupled Adenylate Cyclase System

1982 • 176 citations

Potential antidepressant properties of 8-hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist

1987 • 163 citations

Mechanism of action of benzodiazepines

1975 • 162 citations

The Biochemical Basis of Neuropharmacology.

1979 • 159 citations

Reduced Sensitivity of Lymphocyte Beta-Adrenergic Receptors in Patients with Endogenous Depression and Psychomotor Agitation

1985 • 157 citations

Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.

1975 • 156 citations

Interactions Between Putative Neurotransmitters in the Brain

1978 • 152 citations

Localisation of Tricyclic Antidepressant Binding Sites on Serotonin Nerve Terminals

1981 • 151 citations

Biogenic amine hypothesis of affective disorders

1979 • 148 citations

New perspectives on the mode of action of antidepressant drugs

1979 • 148 citations

Interactions of pharmacological agents which alter biogenic amine metabolism and depression

1979 • 147 citations

The effect of chlordiazepoxide, diazepam and nitrazepam on catecholamine metabolism in regions of the rat brain

1969 • 145 citations

Modulation of neuronal serotonin uptake by a putative endogenous ligand of imipramine recognition sites.

1983 • 145 citations

Bupropion and amitriptyline in the treatment of depressed patients.

1983 • 144 citations

Dopamine and depression: A review of recent evidence. III. The effects of antidepressant treatments

1983 • 144 citations

Hypersensitive Serotonergic Receptors Involved in Clinical Depression—A Theory

1978 • 140 citations

Biochemical and Functional Evidence of Supersensitive Platelet α2-Adrenoceptors in Major Affective Disorder

1986 • 140 citations

Brain noradrenaline depletion prevents ECS-induced enhancement of serotonin-and dopamine-mediated behaviour

1980 • 139 citations

Interactions between reserpine, chlorpromazine, and imipramine

1960 • 138 citations

Retarded depression and the dopamine metabolism

1971 • 138 citations

A Beta Adrenergic Stimulant (Salbutamol) versus Clomipramine in Depression: A Controlled Study

1980 • 138 citations

Are there selective ligands for 5-HT1A and 5-HT1B receptor binding sites in brain?

1986 • 136 citations

Presynaptic Adrenergic Receptor Sensitivity in Depression

1981 • 133 citations

Psychiatric Side Effects of Antihypertensive Drugs Other Than Reserpine

1982 • 131 citations

THE ACTION OF DESMETHYLIMIPRAMINE IN COUNTERACTING SEDATION AND CHOLINERGIC EFFECTS OF RESERPINE-LIKE DRUGS

1964 • 131 citations

Effect of chronic antidepressant treatment and subsequent withdrawal on [3H]-5-hydroxytryptamine and [3H]-spiperone binding in rat frontal cortex and serotonin receptor mediated behaviour

1983 • 126 citations

Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat

1987 • 122 citations

Different Synaptic Location of Mianserin and Imipramine Binding Sites

1982 • 120 citations

Acceleration of β-receptor desensitization in combined administration of antidepressants and phenoxybenzamine

1981 • 118 citations

Neuropharmacology of serotonin

1986 • 116 citations

Antidepressants: Neurochemical, Behavioral, and Clinical Perspectives

1982 • 116 citations

Chronic antidepressants and GABA “B” receptors: A GABA hypothesis of antidepressant drug action

1984 • 115 citations

(—)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone

1981 • 111 citations

Propranolol and depression

1982 • 111 citations

Reduced sensitivity of neurons to noradrenamine after chronic treatment with antidepressant drugs

1980 • 110 citations

Antidepressants : neurochemical, behavioral, and clinical perspectives

1981 • 109 citations

The serotonergic system in the brain and its possible functional connections with other aminergic systems

1975 • 107 citations

Reduced uptake of serotonin but unchanged 3H-imipramine binding in the platelets from cirrhotic patients

1981 • 106 citations

Chronic antidepressant treatment enhances agonist affinity of brain α1-adrenoceptors

1983 • 101 citations

Evidence of dopamine involvement in the effect of repeated treatment with various antidepressants in the behavioural ‘despair’ test in rats

1985 • 99 citations

Spinal serotonin (5-HT) receptor subtypes and nociception.

1983 • 99 citations

Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants

1983 • 96 citations

Down regulation of dihydroalprenolol and imipramine binding sites in brain of rats repeatedly treated with imipramine

1980 • 95 citations

Interactions between clonidine and antidepressant drugs: A method for identifying antidepressant-like agents

1978 • 93 citations

Escape deficits induced by uncontrollable stress: Antagonism by dopamine and norepinephrine agonists

1980 • 93 citations

High-affinity [3H]DMI binding is associated with neuronal noradrenaline uptake in the periphery and the central nervous system

1981 • 92 citations

Correlation between cerebrospinal fluid amine metabolites and psychomotor activity in affective disorders

1977 • 92 citations

Immobility test: effects of 5-hydroxytryptaminergic drugs and role of catecholamines in the activity of some antidepressants

1981 • 90 citations

Involvement of α- and β1-adrenergic mechanisms in the immobility-reducing action of desipramine in the forced swimming test

1983 • 89 citations

Novel Antidepressants and the Biogenic Amine Hypothesis of Depression

1979 • 88 citations

In search of the mode of action of antidepressants 5-HTP/tyrosine mixtures in depressions

1983 • 87 citations

Rapid decrease in rat brain beta adrenergic receptor binding during combined antidepressant alpha-2 antagonist treatment.

1983 • 87 citations

Shuttle-box deficits induced by inescapable shocks in rats: Reversal by the beta-adrenoreceptor stimulants clenbuterol and salbutamol

1986 • 85 citations

Parallel changes in the sensitivity of γ-aminobutyric acid and noradrenergic receptors following chronic administration of antidepressant and GABAergic drugs

1985 • 85 citations

Regulation of neurotransmitter receptors by desipramine and other antidepressant drugs: the neurotransmitter receptor hypothesis of antidepressant action.

1984 • 84 citations

Open trial of buspirone in the treatment of major depressive disorder.

1986 • 83 citations

Do antidepressants possess a common mechanism of action?

1983 • 81 citations

Bupropion: A new antidepressant drug, the mechanism of action of which is not associated with down-regulation of postsynaptic β-adrenergic, serotonergic (5-HT2), α2-adrenergic, imipramine and dopaminergic receptors in brain

1983 • 79 citations

On the mode of action of imipramine: Relationship between serotonergic axon terminal function and down-regulation of $beta;-adrenergic receptors

1983 • 78 citations

Differentiation of two components of specific [3H]imipramine binding in rat brain

1984 • 76 citations

Antidepressant-anxiolytic interaction: Decreased density of benzodiazepine receptors in rat brain following chronic administration of antidepressants

1984 • 75 citations

Chronic treatment with antidepressant drugs: Potentiation of apomorphine-induced aggressive behaviour in rats

1979 • 75 citations

Desipramine-Yohimbine Combination Treatment of Refractory Depression

1986 • 73 citations

Enhanced serotonin receptor activity after chronic treatment with imipramine or amitriptyline.

1979 • 72 citations

The effects of antidepressants and electroconvulsive shocks on the functioning of the mesolimbic dopaminergic system: A behavioral study

1987 • 72 citations

Neuropharmacology and behavior

1973 • 71 citations

Effect of tricyclic antidepressants on the uptake of noradrenaline and 5-hydroxytryptamine by rat brain slices incubated in buffer or human plasma

1973 • 71 citations

Effect of chronic imipramine or baclofen on GABA-B binding and cyclic AMP production in cerebral cortex

1986 • 71 citations

The role of calcium ions in accumulation of cyclic adenosine monophosphate elicited by alpha and beta adrenergic agonists in rat brain slices.

1977 • 69 citations

Differential inhibitory noradrenergic responses to clonidine in 25 depressed patients and 25 normal control subjects

1984 • 69 citations

Biochemical investigations into the mode of action of trazodone

1980 • 69 citations

The effect of nomifensine on the depletion of brain serotonin and catecholamines induced respectively by fenfluramine and 6-hydroxydopamine in rats

1975 • 69 citations

Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs.

1978 • 68 citations

High‐ and Low‐Affinity Binding of [³H]Imipramine in Mouse Cerebral Cortex

1983 • 67 citations

Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrin™)

1981 • 66 citations

Interactions between putative neurotransmitters in the brain

1978 • 66 citations

Repeated treatment with antidepressant drugs potentiates the locomotor response to (+)-amphetamine

1984 • 66 citations

Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine

1983 • 63 citations

Biochemical and pharmacological studies on amineptine (S 1694) and (+)-amphetamine in the rat

1977 • 63 citations

Maprotiline: an antidepressant with an unusual pharmacological profile.

1986 • 63 citations

Annual reports in medicinal chemistry, vol. 21

1987 • 60 citations

The contribution of drug research to investigating the nature of endogenous depression.

1976 • 60 citations

Effect of chronic desipramine treatment on adrenoceptor modulation of [3H]dopamine release from rat nucleus accumbens slices

1985 • 59 citations

‘High affinity’ binding of [3H] desipramine to rat cerebral cortex: Relationship to tricyclic antidepressant-induced inhibition of norepinephrine uptake

1981 • 59 citations

Pharmacology and Neurochemistry of Trazodone

1981 • 59 citations

The Contribution of Drug Research to Investigating the Nature of Endogenous Depression^*

1976 • 58 citations

Evidence that dopamine mechanisms in the nucleus accumbens are selectively involved in the effect of desipramine in the forced swimming test

1987 • 58 citations

Effect of repeated treatment with desipramine in the behavioral “despair” test in rats: Antagonism by “atypical” but not “classical” neuroleptics or antiadrenergic drugs

1984 • 57 citations

Noradrenergic and opioid mediation of tricyclic-induced reversal of escape deficits caused by inescapable shock pretreatment in rats

1986 • 56 citations

Desmethylimipramine Enhances the Release of Endogenous GABA and Other Neuro trans mitter Amino Acids from the Rat Thalamus

1983 • 55 citations

Repeated treatment with imipramine or amitriptyline increases the locomotor response of rats to (+)-amphetamine given into the nucleus accumbens

1985 • 54 citations

Repeated treatment with imipramine and amitriptyline reduced the immobility of rats in the swimming test by enhancing dopamine mechanisms in the nucleus accumbens

1988 • 53 citations

Serotonin receptor changes after chronic antidepressant treatments: Ligand binding, electrophysiological, and behavioral studies

1983 • 53 citations

Effects of chronic antidepressant treatment on serotonin receptor activity in mice

1983 • 52 citations

The lesion of serotonergic neurons does not prevent antidepressant-induced reversal of escape failures produced by inescapable shocks in rats

1986 • 50 citations

Effect of GABAergic drugs in the behavioral ‘despair’ test in rats

1986 • 50 citations

Studies on the mode of action of alpha-methyldopa.

1969 • 47 citations

Chronic treatment with imipramine: Further functional evidence for the enhanced noradrenergic transmission in flexor reflex activity

1983 • 47 citations

The effect of a tetracyclic antidepressant compound, Org GB94, on the turnover of biogenic amines in rat brain

1976 • 45 citations

[On the pharmacology of tofranil (N-(3-dimethylaminopropyl)-iminodibenzyl hydrochloride].

1959 • 45 citations

Neurochemical basis of stress-induced depression.

1985 • 45 citations

Mechanism of action of anxiolytic drugs

1987 • 44 citations

Effect of single and repeated electroconvulsive shock on serotonergic system in rat brain—II behavioural studies

1980 • 43 citations

Behavioral effects of GABA agonists in relation to anxiety and benzodiazepine action

1987 • 41 citations

Subsensitivity of human ?-adrenergic adenylate cyclase after salbutamol treatment of depression

1981 • 41 citations

Antagonism by dopamine, but not noradrenaline receptor blockers of the anti-immobility activity of desipramine after different treatment schedules in the rat

1986 • 39 citations

Reduced metabolism and turnover rates of rat brain dopamine, norepinephrine and serotonin by chronic desipramine and zimelidine treatments

1984 • 38 citations

Clenbuterol, a Central β‐Adrenoceptor Agonist

1980 • 38 citations

Noradrenergic denervation prevents sensitization of rat forebrain neurons to serotonin by tricyclic antidepressant treatment

1987 • 37 citations

The reversal effect of antidepressants on the escape deficit induced by inescapable shock in rats

1983 • 36 citations

Chronic treatment with some atypical antidepressants increases the brain level of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rats

1981 • 36 citations

Effects of long-term treatment of rats with antidepressants on adrenergic-receptor sensitivity in cerebral cortex: Structure activity study

1983 • 35 citations

Striatal dopamine autoreceptors uninfluenced by chronic administration of antidepressants

1982 • 35 citations

Effects of some atypical antidepressants on β-adrenoceptor binding and adenylate cyclase activity in the rat forebrain

1985 • 35 citations

The serotonin/noradrenaline-link in brain

1987 • 35 citations

Daily bupropion injections for 3 weeks attenuate the ne-stimulation of adenylate cyclase and the number of β-adrenergic recognition sites in rat frontal cortex

1983 • 34 citations

The pharmacology of depression: studies of neurotransmitter receptors lead the search for biochemical lesions and new drug therapies

1986 • 34 citations

Bupropion's prophylactic efficacy in bipolar affective illness.

1983 • 33 citations

Tricyclic antidepressants induce subsensitivity of presynaptic dopamine autoreceptors

1980 • 32 citations

High-affinity bindingof [3H]mianserin to rat cerebral cortex

1980 • 32 citations

Synergistic interaction between α- and β -adrenergic receptors in rat brain slices: Possible site for antidepressant drug action

1985 • 30 citations

The effect of diazepam and of agents which change gabaergic functions in immobility in mice

1984 • 30 citations

Neurochemical effects of buspirone in rat hippocampus: evidence for selective activation of 5HT neurons.

1986 • 30 citations

Concurrent use of antidepressants and propranolol: case report and theoretical considerations.

1983 • 29 citations

A comparison of the neurochemical and behavioral effects of clenbuterol and desipramine

1987 • 26 citations

Role of beta-adrenergic receptors in the antidepressant activity of alprazolam.

1982 • 26 citations

Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5‐hydroxytryptamine in man.

1978 • 26 citations

Do antidepressants induce dopamine autoreceptor subsensitivity?

1982 • 25 citations

The GABA hypothesis of depression and antidepressant drug action.

1985 • 25 citations

Binding of [³H]Imipramine to Human Platelet Membranes with Compensation for Saturable Binding to Filters and Its Implication for Binding Studies with Brain Membranes

1984 • 24 citations

Biochemical Studies with Trazodone

2015 • 24 citations

DOWN-REGULATION AT PINEAL β-ADRENOCEPTORS IN DEPRESSED PATIENTS TREATED WITH DESIPRAMINE?

1983 • 23 citations

The ability of antidepressant drugs to desensitize β-receptors is inversely correlated with their clinical potency

1984 • 23 citations

Inhibition of the Central Hypotensive Effect of Clonidine by Trazodone, a Novel Antidepressant

1977 • 22 citations

The in vivo binding of [3H]-desipramine and [3H]-chlorpromazine to1areas in the rat brain

1978 • 20 citations

Further evidence that noradrenaline is not involved in the anti-immobility activity of chronic desipramine in the rat

1987 • 20 citations

Neurochemical and behavioural studies with RU-24969 in the rat

1988 • 19 citations

Selective involvement of dopamine in the nucleus accumbens in the feeding response elicited by muscimol injection in the nucleus raphe dorsalis of sated rats

1986 • 17 citations

Drugs: Guide and caveats to explanatory and descriptive approaches—I. A critical evaluation of the current status of antidepressant drugs

1984 • 15 citations

Antidepressant administration has a differential effect on rat brain α2-adrenoceptor sensitivity to agonists and antagonists

1986 • 14 citations

Different components of 3H-imipramine binding in rat brain membranes: Relation to serotonin uptake sites

1988 • 13 citations

Some aspects of the cardiovascular pharmacology of UK 14,275 in patients with coronary artery disease.

1978 • 12 citations

Long-term antidepressant treatment reduces neuronal responsiveness to flurazepam: An electrophysiological study in the rat

1987 • 10 citations

NEW DIRECTION TO THE AMINE HYPOTHESIS

1977 • 10 citations

Dopamine autoreceptors in the ventral tegmental area show subsensitivity following withdrawal from chronic antidepressant drug treatment

1986 • 9 citations

A controlled clinical study of a new antidepressant (trazodone).

1971 • 9 citations

Chapter 1. Antidepressants

1980 • 5 citations

Chronic treatment with iprindole reduces immobility of rats in the behavioural ‘despair’ test by activating dopaminergic mechanisms in the brain

1986 • 5 citations

Effects of Acute and Repeated Administration of Antidepressant Serotonin Uptake Blockers

2015 • 4 citations

[Monoamines and the pharmacological effects of tricyclic antidepressive agents].

1972 • 3 citations