Chronic antidepressant treatment enhances agonist affinity of brain α1-adrenoceptors

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves

1910 • 2,184 citations

EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.

1965 • 1,543 citations

A graphic method for the determination and presentation of binding parameters in a complex system

1967 • 1,524 citations

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment

1981 • 645 citations

Mode of action of antidepressant drugs

1978 • 514 citations

Binding characteristics of 3H-prazosin to rat brain α-adrenergic receptors

1979 • 419 citations

A possible common mechanism of action of antidepressant treatments

1976 • 410 citations

Effect of clonidine on growth hormone release in psychiatric patients and controls

1980 • 377 citations

Tricyclic Antidepressants: Therapeutic Properties and Affinity for α-Noradrenergic Receptor Binding Sites in the Brain

1978 • 360 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Growth Hormone and other Responses to Clonidine in Patients with Endogenous Depression

1981 • 300 citations

Tricyclic antidepressants: Effects on the firing rate of brain noradrenergic neurons

1975 • 224 citations

Alpha adrenoceptors in rat brain: Direct identification with prazosin

1979 • 136 citations

The effect of imipramine and lithium on α- and β-receptor binding in rat brain

1979 • 133 citations

α1-adrenoceptor-mediated responses in the lateral geniculate nucleus are enhanced by chronic antidepressant treatment

1981 • 130 citations

Effect of antidepressant drugs on serotonergic and adrenergic receptors

1980 • 129 citations

Regulation of the postsynaptic alpha-adrenergic receptor in rat mesenteric artery. Effects of chemical sympathectomy and epinephrine treatment.

1981 • 125 citations

Prazosin selectively antagonizes neuronal responses mediated by ?1-adrenoceptors in brain

1981 • 121 citations

Chronic antidepressant treatment enhances α-adrenergic and serotonergic responses in the facial nucleus

1980 • 120 citations

β-Adrenergic Regulation of α ₃ -Adrenergic Receptors in the Central Nervous System

1980 • 118 citations

3H-prazosin binds specifically to ??1?-Adrenoceptors in rat brain

1980 • 112 citations

Amitriptyline: Long-term treatment elevates α-adrenergic and muscarinic receptor binding in mouse brain

1980 • 93 citations

Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: Selective blockade by the alpha1-adrenoceptor antagonist prazosin

1982 • 89 citations

A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slices

1971 • 88 citations

Differential effect of chronic desipramine and amitriptyline treatment on rat brain adrenergic and serotonergic receptors

1981 • 84 citations

Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization.

1979 • 82 citations

Effect of Drugs on Amines in the CNS

1971 • 82 citations

Effects of chronic administration of antidepressant drugs on aggressive behavior induced by clonidine in mice

1980 • 66 citations

The effect of repeated administration of antidepressant drugs on the responsiveness of rats to catecholamine agonists

1979 • 66 citations

α-adrenoceptors in rat brain: Sodium changes the affinity of agonists for prazosin sites

1980 • 60 citations

Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.

1981 • 48 citations

Role of .ALPHA.-adrenergic receptors in denervation supersensitivity of rat vas deferens.

1981 • 21 citations

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