Mechanism of action of anxiolytic drugs

Handbook of Psychopharmacology

1988 • 2,778 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors

1985 • 1,855 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

1983 • 869 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors

1985 • 803 citations

Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.

1983 • 631 citations

Discrimination of Multiple [³H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain

1981 • 629 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

1981 • 559 citations

New concepts on the mechanism of action of benzodiazepines

1975 • 539 citations

Clinical Pharmacokinetics of Diazepam

1978 • 490 citations

An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain

1978 • 467 citations

The neurobiology of the nucleus accumbens

1982 • 454 citations

The comparative efficacy of buspirone and diazepam in the treatment of anxiety

1979 • 426 citations

Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors

1979 • 412 citations

Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors

1979 • 408 citations

Withdrawal Reaction after Long-Term Therapeutic Use of Benzodiazepines

1986 • 371 citations

The neuropsychology of anxiety*

1978 • 355 citations

Benzodiazepines in Clinical Practice

1974 • 317 citations

A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, ?-carbolines, and phenobarbitone

1982 • 312 citations

A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxiety

1979 • 284 citations

The pharmacokinetics of midazolam in man

1981 • 273 citations

Benzodiazepine recognition site ligands: biochemistry and pharmacology.

1983 • 244 citations

Ethyl β-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats

1981 • 225 citations

Benzodiazepine Antagonist Ro 15–1788: Binding Characteristics and Interaction with Drug‐Induced Changes in Dopamine Turnover and Cerebellar cGMP Levels

1982 • 222 citations

Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

1984 • 221 citations

Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.

1986 • 215 citations

Monoclonal antibodies reveal structural homogeneity of gamma-aminobutyric acid/benzodiazepine receptors in different brain areas.

1985 • 205 citations

β-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity

1980 • 193 citations

CGS 8216: Receptor binding characteristics of a potent benzodiazepine antagonist

1982 • 192 citations

Photoaffinity Labeling of Benzodiazepine Receptor Proteins with the Partial Inverse Agonist [³H]Ro 15–4513: A Biochemical and Autoradiographic Study

1987 • 191 citations

Treatment of Status Epilepticus with Diazepam (Valium)*

1965 • 184 citations

Neurobiological mechanisms in human anxiety evidence supporting central noradrenergic hyperactivity

1983 • 184 citations

Alprazolam

1984 • 174 citations

3H-TVX Q 7821: identification of 5-HT1 binding sites as target for a novel putative anxiolytic

1985 • 174 citations

Benzodiazepines attenuate single unit activity in the locus coeruleus

1980 • 165 citations

Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor.

1986 • 150 citations

Benzodiasepine and neurotransmitter receptor binding in rat brain after chronic administration of diazepam or phenobarbital

1978 • 146 citations

Buspirone: Effects on central monoaminergic transmission - possible relevance to animal experimental and clinical findings

1982 • 139 citations

Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821

1984 • 138 citations

The primate locus coeruleus and effects of clonidine on opiate withdrawal.

1982 • 137 citations

The effects of p-chlorophenylalanine on experimentally induced conflict in the rat

1969 • 135 citations

Pustative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphé nuclei

1986 • 128 citations

INVESTIGATION IN MAN OF THE EFFICACY OF A BENZODIAZEPINE ANTAGONIST, Ro 15-1788

1981 • 128 citations

Buspirone: Action on serotonin receptors in calf hippocampus

1983 • 127 citations

Multiple benzodiazepine receptors: Evidence of a dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives)

1981 • 120 citations

Behavioral and neurochemical studies on the anticonflict actions of buspirone

1984 • 119 citations

1-(2-Pyrimidinyl)-Piperazine as Active Metabolite of Buspirone in Man and Rat

1986 • 117 citations

and inhibition by zopiclone of benzodiazepine binding to rodent brain receptors

1979 • 117 citations

Effect of specific serotonergic lesions on cholinergic neurons in the hippocampus, cortex and striatum

1983 • 116 citations

The Benzodiazepines: From molecular biology to clinical practice

1983 • 112 citations

Benzodiazepines in clinical practice

1975 • 106 citations

Monoamine Neurons Innervating the Hippocampal Formation and Septum: Organization and Response to Injury

1975 • 104 citations

An allosteric model for benzodiazepine receptor function

1983 • 102 citations

Pharmacokinetics of single and multiple doses of clobazam in humans.

1979 • 99 citations

Medicine and the Law

1979 • 99 citations

Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity

1982 • 98 citations

Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam

1981 • 98 citations

Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules

1977 • 97 citations

ANXIETY

1982 • 84 citations

Antidepressant-anxiolytic interaction: Decreased density of benzodiazepine receptors in rat brain following chronic administration of antidepressants

1984 • 75 citations

Changing concepts of the biochemical action of the anxioselective drug, buspirone

1984 • 75 citations

Buspirone: An anxiolytic without sedative effect

1985 • 74 citations

Dopaminergic effects of buspirone, a novel anxiolytic agent

1983 • 72 citations

Benzodiazepine receptors resolved

1986 • 72 citations

Isolation and identification in bovine cerebral cortex of n-butyl beta-carboline-3-carboxylate, a potent benzodiazepine binding inhibitor.

1986 • 71 citations

Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin

1981 • 71 citations

Comparative neuropharmacology of buspirone and MJ-13805, a potential anti-anxiety drug

1983 • 71 citations

Multiple benzodiazepine receptors: Structures in the brain or structures in the mind? A critical review

1983 • 68 citations

Buspirone as a midbrain modulator: Anxiolysis unrelated to traditional benzodiazepine mechanisms

1984 • 68 citations

Buspirone enhances [3H]flunitrazepam binding in vivo

1983 • 65 citations

Maprotiline: an antidepressant with an unusual pharmacological profile.

1986 • 63 citations

The effects of benzodiazepine and non-benzodiazepine anxiolytics on locus coeruleus unit activity

1983 • 63 citations

Buspirone: A potential atypical neuroleptic

1983 • 61 citations

Receptors in pharmacology

1978 • 61 citations

CORRELATION OF BRAIN MONOAMINE OXIDASE ACTIVITY WITH BEHAVIOURAL CHANGES AFTER IPRONIAZID AND 5‐HYDROXYTRYPTOPHAN ADMINISTRATION†

1961 • 59 citations

Disposition and metabolism of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in the rat

1983 • 58 citations

Flurazepam hydrochloride

1975 • 57 citations

Decrease in rat striatal acetylcholine levels by some direct- and indirect-acting dopaminergic antagonists

1975 • 56 citations

Reduction in cortical 5HT2 receptor sensitivity after continuous gepirone treatment

1985 • 56 citations

Benzodiazepine receptors': Correlation with pharmacological responses in living animals

1982 • 53 citations

Effects of acute diazepam and clobazam on spontaneous locomotor activity and central amine metabolism in rats

1977 • 50 citations

Selective effects of buspirone and molindone on dopamine metabolism and function in the striatum and frontal cortex of the rat

1983 • 50 citations

PHARMACOLOGICAL PROFILE OF TWO BENZODIAZEPINE PARTIAL AGONISTS

1984 • 49 citations

Regional heterogeneity of benzodiazepine receptors at 37°C: An study in various regions of the rat brain

1982 • 46 citations

Differential effects of amphetamine, fenfluramine and norfenfluramine stereoisomers on the increase of striatum homovanillic acid in rats

1973 • 44 citations

Pharmacological evidence for the involvement of 1-(2-pyridinyl)-piperazine (1-PmP) in the interaction of buspirone or gepirone with noradrenergic systems

1987 • 43 citations

Benzodiazepine receptor antagonists reverse the effect of diazepam on plasma corticosterone in stressed rats

1984 • 43 citations

Effect of fenfluramine and norfenfluramine stereoisomers on stimulant effects of d-amphetamine and apomorphine in the rat

1980 • 42 citations

PHARMACOLOGICAL STUDIES ON NEW POTENT CENTRAL DEPRESSANTS, 8-CHLORO-6-PHENYL-4H-s-TRIAZOLO [4, 3a] [1, 4] BENZODIAZEPINE (D-40TA) AND ITS 1-METHYL ANALOGUE (D-65MT)

1971 • 42 citations

Disposition of the psychotropic drugs buspirone, MJ-13805 and piribedil, and of their common active metabolite 1-(2-pyrimidinyl)-piperazine in the rat

1985 • 41 citations

CL 218872 antagonism of diazepam induced loss of righting reflex: Evidence for partial agonistic activity at the benzodiazepine receptor

1983 • 38 citations

Medicinal chemistry advances

1983 • 38 citations

Buspirone decreases the activity of 5-hydroxytryptamine-containing dorsal raphe neurons in-vitro

1986 • 38 citations

Anticonvulsant Potency of Unmetabolized Diazepam

1982 • 35 citations

Anxiolytic activity on locus coeruleus-mediated suppression of muricidal aggression

1984 • 32 citations

Diazepam increases membrane fluidity of rat hippocampus synaptosomes

1984 • 30 citations

Benzodiazepines: Relationship between pharmacological activity in the rat and in vivo receptor binding

1982 • 27 citations

Central serotonin agonist actions of LY 165163, 1-(m-trifluoromethylphenyl)-4-(p-aminophenylethyl) piperazine, in rats.

1986 • 26 citations

Benzodiazepine inhibition of adenosine uptake is not prevented by benzodiazepine antagonists

1983 • 26 citations

Neurochemical effects of buspirone, a novel psychotropic drug, on the central cholinergic system

1982 • 26 citations

Theoretical and experimental bases of the behaviour therapies

1976 • 24 citations

The Biotransformation of 8-Chloro-6-phenyl-4H-s-triazolo[4, 3-a][1,4] benzodiazepine (D-40TA), a New Central Depressant, in Man, Dog and Rat

1974 • 22 citations

Species differences in clobazam metabolism and antileptazol effect

1980 • 21 citations

Anxiolytic versus sedative properties in the benzodiazepines series: Differencies in structure - activity relationships

1979 • 21 citations

Metabolism of 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo [4,3-a] [1,4]benzodiazepine, triazolam, a new central depressant. II. Identification and determination of metabolites in rats and dogs

1979 • 18 citations

Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of rat

1985 • 15 citations

Theoretical and Experimental Bases of the Behaviour Therapies

1977 • 15 citations

Relationship between camazepam, N-methyl-oxazepam and oxazepam brain concentrations and antileptazol effect in the rat

1981 • 15 citations

The effect of diazepam on indices of 5-HT function in man

1986 • 14 citations

Kinetic and pharmacological studies on estazolam in mice and man

1985 • 13 citations

Chlordiazepoxide antagonizes locus coeruleus-mediated suppression of muricidal aggression

1983 • 13 citations

Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors

1982 • 12 citations

Benzodiazepines stimulate muscimol receptor binding in an Ro 15-1788 reversible manner

1983 • 11 citations

Benzodiazepine Recognition Site Ligands

1985 • 10 citations

Differential effects of the isomers of fenfluramine and norfenfluramine on rat striatal acetylcholine content

1979 • 9 citations

Central Mechanisms of Fenfluramine and Related Anorectic Drugs

1981 • 9 citations

Pharmacological and Biochemical Studies on Benzodiazepines

1981 • 9 citations

In vivo interaction of premazepam with benzodiazepine receptors: Relation to its pharmacological effects

1985 • 7 citations

Increased number of brain benzodiazepine receptors after in-vivo administration of estazolam to rats

1984 • 5 citations

EFFECTS OF EXCITATORY TRANSMITTER CANDIDATES ON FROG SPINAL MOTOR FUNCTION

1979 • 5 citations

Introduction

1975 • 3 citations