Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats

1976 • 706 citations

A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-Trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine

1974 • 461 citations

Antidepressants and the Muscarinic Acetylcholine Receptor

1977 • 429 citations

Effects of antidepressant drugs on different receptors in the brain

1981 • 325 citations

Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression

1977 • 264 citations

Ascending catecholamine pathways and amphetamine-induced locomotor activity: Importance of dopamine and apparent non-involvement of norepinephrine

1975 • 259 citations

ehavioural evidence for supersensitivtiy of postsynaptic dopamine receptors in the mesolimbic system after chronic administration of desipramine

1981 • 239 citations

Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system

1981 • 216 citations

The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumbens, and medial prefrontal cortex.

1978 • 211 citations

Faster Cholinergic REM Sleep Induction in Euthymic Patients with Primary Affective Illness

1980 • 198 citations

Chronic treatment with antidepressants prevents the inhibitory effect of small doses of apomorphine on dopamine synthesis and motor activity

1979 • 193 citations

CATECHOLAMINE CONTENT OF SPINAL CORD

1962 • 163 citations

Increased Intracranial Self-Stimulation in Rats After Long-Term Administration of Desipramine

1981 • 152 citations

Physostigmine: Effects on cognition and affect in normal subjects

1976 • 140 citations

Brain noradrenaline depletion prevents ECS-induced enhancement of serotonin-and dopamine-mediated behaviour

1980 • 139 citations

Mood and Behavioral Effects of Physostigmine on Humans Are Accompanied by Elevations in Plasma β-Endorphin and Cortisol

1980 • 137 citations

The pharmacology of zimelidine: A 5‐HT selective reuptake inhibitor

1981 • 110 citations

Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system

1978 • 99 citations

Nature and mechanisms of cholinergic-monoaminergic interactions in the brain

1977 • 96 citations

The effects of 5,7-dihydroxytryptamine lesions of extrapyramidal and mesolimbic sites on spontaneous motor behaviour, and amphetamine-induced stereotypy

1979 • 96 citations

beta-Endorphin hypersecretion in depression: possible cholinergic mechanisms.

1982 • 87 citations

Differential effect of chronic desipramine and amitriptyline treatment on rat brain adrenergic and serotonergic receptors

1981 • 84 citations

Repeated electroconvulsive shock prevents the sedative effect of small doses of apomorphine

1981 • 77 citations

Neuroendocrine evidence for increased responsiveness of dopamine receptors in humans following electroconvulsive therapy

1982 • 71 citations

Specific Noradrenergic Neurones destroyed by 6-Hydroxydopamine Injection into Newborn Rats

1972 • 71 citations

Increased sensitivity to dopaminergic agonists after repeated electroconvulsive shock (ECS) in rats

1981 • 66 citations

Differential effects of central serotonin manipulation on hyperactive and stereotyped behaviour

1978 • 59 citations

REM sleep deprivation induces subsensitivity of dopamine receptors mediating sedation in rats

1981 • 54 citations

An enhanced sensitivity of muscarinic cholinergic receptor associated with dopaminergic receptor subsensitivity after chronic antidepressant treatment

1981 • 34 citations

Tricyclic antidepressants induce subsensitivity of presynaptic dopamine autoreceptors

1980 • 32 citations

A comparative review of the pharmacology of nomifensine.

1977 • 31 citations

Antidepressant drugs and dopamine uptake in different brain regions

1977 • 28 citations

Distinction between dopaminergic and serotonergic components of neuroleptic binding sites in limbic brain areas

1979 • 28 citations

A Quantitative Study of Cholinergic-Dopaminergic Interactions in the Central Nervous System

1982 • 23 citations

Reduced presynaptic dopamine receptor density after chronic antidepressant treatment in rats

1982 • 22 citations

Neonatal 6-hydroxydopamine treatment: Noradrenaline levels and in vitro 3H-catecholamine synthesis in discrete brain regions of adult rats

1974 • 14 citations