Gender differences in autoimmunity: molecular basis for estrogen effects in systemic lupus erythematosus

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1

1997 • 1,098 citations

The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1

1999 • 1,055 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

A Gender Gap in Autoimmunity

1999 • 856 citations

Steroid Receptor Family: Structure and Functions

1990 • 820 citations

Skeletal Effects of Estrogen*

1994 • 722 citations

Dubois' Lupus Erythematosus

1988 • 675 citations

Gonadal Steroids and Immunity*

1996 • 667 citations

The vascular protective effects of estrogen

1996 • 642 citations

Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice.

1978 • 637 citations

Human Estrogen Receptor -Gene Structure, Chromosomal Localization, and Expression Pattern

1997 • 576 citations

Current protocols in immunology

1993 • 551 citations

Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.

1997 • 534 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

The novel estrogen receptor‐β subtype: potential role in the cell‐ and promoter‐specific actions of estrogens and anti‐estrogens

1997 • 406 citations

Mode of Action of Tacrolimus (FK506): Molecular and Cellular Mechanisms

1995 • 382 citations

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

1999 • 358 citations

Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT

1998 • 298 citations

Manipulating Immune Responses with Immunosuppressive Agents that Target NFAT

2000 • 279 citations

Network Theory in Autoimmunity

1981 • 271 citations

Dubois' Lupus Erythematosus

2002 • 271 citations

Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras¹

1998 • 267 citations

Estrogen enhances immunoglobulin production by human PBMCs

1999 • 257 citations

Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization

1999 • 254 citations

Mechanisms of Transcriptional Activation of bcl-2 Gene Expression by 17β-Estradiol in Breast Cancer Cells

1999 • 253 citations

The role of sex hormones in systemic lupus erythematosus

1999 • 237 citations

The Estrogen Receptor -Isoform (ER ) of the Human Estrogen Receptor Modulates ER Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens

1999 • 223 citations

Sex steroid hormones and macrophage function

1996 • 213 citations

Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus

1998 • 209 citations

Increased 16α-Hydroxylation of Estradiol in Systemic Lupus Erythematosus*

1981 • 208 citations

Estrogen Regulation of c-fosMessenger Ribonucleic Acid

1988 • 205 citations

Gender and risk of autoimmune diseases: possible role of estrogenic compounds.

1999 • 183 citations

Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology

1993 • 181 citations

Estrogen enhancement of anti–double‐stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

1999 • 169 citations

TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.

1995 • 168 citations

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

1989 • 163 citations

Suppressor-Cell Dysfunction in Systemic Lupus Erythematosus

1978 • 162 citations

Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis

1998 • 143 citations

Estrogen enhancement of anti-double-stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

1999 • 140 citations

The Duration of Nuclear Residence of NFAT Determines the Pattern of Cytokine Expression in Human SCID T Cells

2000 • 132 citations

The −180 Site of the IL-2 Promoter Is the Target of CREB/CREM Binding in T Cell Anergy

1999 • 127 citations

Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells.

1998 • 124 citations

Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17β-Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes*

1999 • 121 citations

Effect of Pregnancy on Course of Systemic Lupus Erythematosus

1963 • 118 citations

Oral contraceptives and systemic lupus erythematosus

1997 • 118 citations

Low plasma androgens in women with active or quiescent systemic lupus erythematosus

1982 • 117 citations

Immune cell signaling defects in lupus: activation, anergy and death

1999 • 115 citations

The T cell enigma in lupus

1996 • 106 citations

Estrogen Decreasesin VitroApoptosis of Peripheral Blood Mononuclear Cells from Women with Normal Menstrual Cycles and Decreases TNF-α Production in SLE but Not in Normal Cultures

1997 • 96 citations

Increased oxidation of testosterone in systemic lupus erythematosus

1983 • 84 citations

Ten years after: reclassification of steroid-responsive genes.

1996 • 80 citations

Oral contraceptives and systemic lupus erythematosus

1980 • 76 citations

Relations between steroid hormones and cytokines in rheumatoid arthritis and systemic lupus erythematosus

1998 • 73 citations

Lupus : molecular and cellular pathogenesis

1999 • 72 citations

Transcription Activation by the Human Estrogen Receptor Subtype (ER ) Studied with ER and ER Receptor Chimeras

1998 • 66 citations

Gender Differences in Autoimmune Diseases: Estrogen Increases Calcineurin Expression in Systemic Lupus Erythematosus

1998 • 66 citations

MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTION

1991 • 65 citations

Hormonal modulation in systemic lupus erythematosus. Preliminary clinical and hormonal results with cyproterone acetate

1985 • 61 citations

Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins.

1997 • 60 citations

Molecular Mechanisms Involved in the Estrogen-Dependent Regulation of Calcineurin in Systemic Lupus Erythematosus T Cells

2000 • 55 citations

Ten years after: reclassification of steroid-responsive genes

1996 • 49 citations

Evidence for the genetic control of estradiol-regulated responses. Implications for variation in normal and pathological hormone-dependent phenotypes.

1997 • 48 citations

Lupus---molecular and cellular pathogenesis.

2000 • 48 citations

Oestrogen and progesterone control basic fibroblast growth factor mRNA in the rat uterus

1997 • 46 citations

Skeletal effects of estrogens

1999 • 39 citations

In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3′-flanking region of the murine c-fos protooncogene

1994 • 37 citations

High prevalence of T cell type I protein kinase a deficiency in systemic lupus erythematosus

1999 • 35 citations

Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17 -Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes

1999 • 32 citations

INADEQUATE PRODUCTION OF PROGESTERONE IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

1992 • 30 citations

Female sex hormones at the onset of systemic lupus erythematosus affect survival

1998 • 28 citations

Sex Hormones as Immunomodulators of Disease

1993 • 28 citations

Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron

1995 • 28 citations

Binding affinity and quantity of estrogen receptor in peripheral blood monocytes of patients with systemic lupus erythematosus

1996 • 28 citations

Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lprmice

1995 • 25 citations

Alternative splicing and differential targeting of fibroblast growth factor receptor 1 in the pregnant rat uterus.

1995 • 23 citations

INFLUENCE OF STEROID HORMONES ON PROLIFERATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH RHEUMATOID ARTHRITIS

1992 • 21 citations

Activation of Uteroglobin Gene Expression by Progesterone Is Modulated by Uterine-Specific Promoter-Binding Proteins

1991 • 20 citations

Lupus

1999 • 16 citations

Molecular cloning and characterization of the promoter region of the calcineurin Aα gene

1992 • 11 citations

Alternative splicing and differential targeting of fibroblast growth factor receptor 1 in the pregnant rat uterus

1995 • 10 citations

Increases in Protein Phosphatase 2B Activity in Lymphoid Tissues and T-Lymphocytes of Autoimmune MRL/MpJ-lpr/lpr Mice1

1993 • 10 citations

Oestrogens, Bones Systemic Lupus Erythematosus

1993 • 6 citations