Gender Differences in Autoimmune Diseases: Estrogen Increases Calcineurin Expression in Systemic Lupus Erythematosus

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Dubois' Lupus Erythematosus

1988 • 675 citations

Gonadal Steroids and Immunity*

1996 • 667 citations

Current protocols in immunology

1993 • 551 citations

Mode of Action of Tacrolimus (FK506): Molecular and Cellular Mechanisms

1995 • 382 citations

Dubois' Lupus Erythematosus

1994 • 360 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Suppressor T-cell abnormality in idiopathic systemic lupus erythematosus

1976 • 314 citations

Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects.

1997 • 311 citations

Sex steroid receptors in peripheral T cells: absence of androgen receptors and restriction of estrogen receptors to OKT8-positive cells.

1983 • 308 citations

Estrogens, the immune response and autoimmunity.

1995 • 287 citations

Dubois' Lupus Erythematosus

2002 • 271 citations

Sex hormone modulation of autoimmunity in NZB/NZW mice

1979 • 233 citations

Sex Steroids and Growth Factors Differentially Regulate the Growth and Differentiation of Cultured Human Endometrial Stromal Cells*

1991 • 222 citations

Increased 16α-Hydroxylation of Estradiol in Systemic Lupus Erythematosus*

1981 • 208 citations

Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology

1993 • 181 citations

TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.

1995 • 168 citations

Oestrogen and Human T Lymphocytes: Presence of Specific Receptors in the T‐Suppressor/Cytotoxic Subset

1988 • 164 citations

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

1989 • 163 citations

Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells.

1998 • 124 citations

The CD40L Promoter Contains Nuclear Factor of Activated T Cells-binding Motifs Which Require AP-1 Binding for Activation of Transcription

1996 • 119 citations

Effect of Pregnancy on Course of Systemic Lupus Erythematosus

1963 • 118 citations

Oral contraceptives and systemic lupus erythematosus

1997 • 118 citations

Low plasma androgens in women with active or quiescent systemic lupus erythematosus

1982 • 117 citations

The T cell enigma in lupus

1996 • 106 citations

Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene.

1992 • 100 citations

Estrogen Decreasesin VitroApoptosis of Peripheral Blood Mononuclear Cells from Women with Normal Menstrual Cycles and Decreases TNF-α Production in SLE but Not in Normal Cultures

1997 • 96 citations

Protein (serine and threonine) phosphate phosphatases

1984 • 92 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.

1994 • 90 citations

Presence of estrogen‐binding sites on macrophage‐like synoviocytes and cd8+, cd29+, cd45ro+ t lymphocytes in normal and rheumatoid synovium

1993 • 84 citations

Ten years after: reclassification of steroid-responsive genes.

1996 • 80 citations

Oral contraceptives and systemic lupus erythematosus

1980 • 76 citations

MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTION

1991 • 65 citations

Hormonal modulation in systemic lupus erythematosus. Preliminary clinical and hormonal results with cyproterone acetate

1985 • 61 citations

Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins.

1997 • 60 citations

Potentiation of Progesterone Receptor-Mediated Transcription by the Immunosuppressant FK506

1994 • 51 citations

Systemic Lupus Erythematosus

1992 • 48 citations

Oestrogen and progesterone control basic fibroblast growth factor mRNA in the rat uterus

1997 • 46 citations

Oestrogen influences CD4+ T-lymphocyte activity in vivo and in vitro in beta 2-microglobulin-deficient mice.

1995 • 38 citations

In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3′-flanking region of the murine c-fos protooncogene

1994 • 37 citations

Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization.

1997 • 34 citations

INADEQUATE PRODUCTION OF PROGESTERONE IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

1992 • 30 citations

Sex Hormones as Immunomodulators of Disease

1993 • 28 citations

Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron

1995 • 28 citations

Biological mechanisms underlying RU 486 clinical effects: inhibition of endometrial stromal cell tissue factor content.

1994 • 26 citations

Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lprmice

1995 • 25 citations

Analysis of proteins that interact with the IL-2 regulatory region in patients with rheumatic diseases

1995 • 25 citations

INFLUENCE OF STEROID HORMONES ON PROLIFERATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH RHEUMATOID ARTHRITIS

1992 • 21 citations

Activation of Uteroglobin Gene Expression by Progesterone Is Modulated by Uterine-Specific Promoter-Binding Proteins

1991 • 20 citations

Immune cell biochemical abnormalities in systemic lupus erythematosus.

1998 • 20 citations

Occasional Series Why women?

1997 • 12 citations

Molecular cloning and characterization of the promoter region of the calcineurin Aα gene

1992 • 11 citations

Increases in Protein Phosphatase 2B Activity in Lymphoid Tissues and T-Lymphocytes of Autoimmune MRL/MpJ-lpr/lpr Mice1

1993 • 10 citations

Systemic lupus erythematosus.

1990 • 9 citations

Oestrogens, Bones Systemic Lupus Erythematosus

1993 • 6 citations