Neuropilin-1 Regulates Vascular Endothelial Growth Factor–Mediated Endothelial Permeability

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

VEGF-receptor signal transduction

2003 • 846 citations

A requirement for neuropilin-1 in embryonic vessel formation

1999 • 830 citations

Microvascular Permeability

1999 • 769 citations

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

2003 • 758 citations

Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development

2003 • 707 citations

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1999 • 681 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung

2004 • 567 citations

Neuropilin-1 Mediates Collapsin-1/Semaphorin III Inhibition of Endothelial Cell Motility

1999 • 469 citations

VEGF₁₆₅ mediates formation of complexes containing VEGFR‐2 and neuropilin‐1 that enhance VEGF₁₆₅‐receptor binding

2002 • 456 citations

The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells

1997 • 436 citations

Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors

1998 • 418 citations

Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs

1995 • 412 citations

Neuropilin-2 and Neuropilin-1 Are Receptors for the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF) and of Placenta Growth Factor-2, but Only Neuropilin-2 Functions as a Receptor for the 145-Amino Acid Form of VEGF

2000 • 411 citations

Regulation of vascular permeability by vascular endothelial growth factors

2002 • 404 citations

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1993 • 369 citations

Neuropilin-1 Is a Placenta Growth Factor-2 Receptor

1998 • 344 citations

Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins

1998 • 320 citations

Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin-sensitive Phosphorylation of Focal Adhesion Kinase

2000 • 314 citations

Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1

1999 • 304 citations

Vascular Permeability Factor (VPF)/Vascular Endothelial Growth Factor (VEGF) Receptor-1 Down-modulates VPF/VEGF Receptor-2-mediated Endothelial Cell Proliferation, but Not Migration, through Phosphatidylinositol 3-Kinase-dependent Pathways

2001 • 301 citations

Vascular Endothelial Growth Factor Receptor-2 and Neuropilin-1 Form a Receptor Complex That Is Responsible for the Differential Signaling Potency of VEGF165 and VEGF121

2001 • 298 citations

The interaction of Neuropilin-1 with Vascular Endothelial Growth Factor and its receptor Flt-1

2000 • 289 citations

Lung Overexpression of the Vascular Endothelial Growth Factor Gene Induces Pulmonary Edema

2000 • 279 citations

A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities

1998 • 252 citations

Regulation of microvascular permeability by vascular endothelial growth factors*

2002 • 250 citations

VEGF induces NO-dependent hyperpermeability in coronary venules

1996 • 247 citations

Receptor Chimeras Indicate That the Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Modulates Mitogenic Activity of VEGFR-2 in Endothelial Cells

2000 • 236 citations

Vascular Endothelial Growth Factor May Contribute to Increased Vascular Permeability in Acute Respiratory Distress Syndrome

2001 • 229 citations

Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF ₁₂₁ and VEGF ₁₆₅ but not VEGF ₁₈₉

1997 • 224 citations

Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell Migration

2003 • 210 citations

The Interaction of Neuropilin-1 with Vascular Endothelial Growth Factor and Its Receptor Flt-1

2000 • 199 citations

VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo

1998 • 195 citations

Increased Vascular Endothelial Growth Factor Production in the Lungs of Rats with Hypoxia-induced Pulmonary Hypertension

1998 • 183 citations

Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury

2002 • 142 citations

VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice

2004 • 125 citations

Regulated Angiogenesis and Vascular Regression in Mice Overexpressing Vascular Endothelial Growth Factor in Airways

2004 • 122 citations

A Novel Snake Venom Vascular Endothelial Growth Factor (VEGF) Predominantly Induces Vascular Permeability through Preferential Signaling via VEGF Receptor-1

2004 • 109 citations

A Mutant Form of Vascular Endothelial Growth Factor (VEGF) That Lacks VEGF Receptor-2 Activation Retains the Ability to Induce Vascular Permeability

1999 • 105 citations

VEGFR-2-specific ligand VEGF-E induces non-edematous hyper-vascularization in mice

2003 • 97 citations

Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells

2001 • 91 citations

Semaphorins as signals for cell repulsion and invasion

2002 • 90 citations

Viral Vascular Endothelial Growth Factors Vary Extensively in Amino Acid Sequence, Receptor-binding Specificities, and the Ability to Induce Vascular Permeability yet Are Uniformly Active Mitogens

2003 • 69 citations

Semaphorins as signals for cell repulsion and invasion

2002 • 68 citations

Oxygen-Independent Upregulation of Vascular Endothelial Growth Factor and Vascular Barrier Dysfunction during Ventilated Pulmonary Ischemia in Isolated Ferret Lungs

2000 • 61 citations

VEGF-A AND -C but not -B mediate increased vascular permeability in preserved lung grafts1

2002 • 51 citations

The shortest isoform of human vascular endothelial growth factor/vascular permeability factor (VEGF/VPF121) produced by Saccharomyces cerevisiae promotes both angiogenesis and vascular permeability

1995 • 41 citations

Co-expression of endothelin-1 and vascular endothelial growth factor mediates increased vascular permeability in lung grafts before reperfusion

2002 • 29 citations

VEGF, fetal liver kinase-1, and permeability increase during unilateral lung ischemia

2000 • 25 citations