Butyrate Suppression of Colonocyte NF-κB Activation and Cellular Proteasome Activity

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

Butyrate inhibits inflammatory responses through NFkappa B inhibition: implications for Crohn's disease

2000 • 1,196 citations

Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity

1999 • 914 citations

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2000 • 794 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis

1992 • 737 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

The effect of sodium butyrate on histone modification

1978 • 680 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer

1993 • 539 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.

1978 • 474 citations

The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line

2000 • 474 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

IκB–NF-κB Structures

1998 • 439 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

Role of short-chain fatty acids in the prevention of colorectal cancer

1995 • 349 citations

Roles of ubiquitin-mediated proteolysis in cell cycle control

1997 • 348 citations

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts

1999 • 322 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon

1989 • 297 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

The ubiquitin-mediated proteolytic pathway: Mode of action and clinical implications

2000 • 276 citations

Rationale for the luminal provision of butyrate in intestinal diseases

2000 • 257 citations

Proteasome Inhibition: a New Strategy in Cancer Treatment

2000 • 252 citations

Butyrate and the Colonocyte

1997 • 251 citations

Apoptosis induction resulting from proteasome inhibition

1996 • 249 citations

Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis.

1994 • 237 citations

Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones

1999 • 228 citations

The ubiquitin-proteasome pathway in cancer

1998 • 223 citations

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo.

1996 • 197 citations

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

1999 • 197 citations

The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer

1999 • 192 citations

Proteasome Inhibitor PS519 Reduces Infarction and Attenuates Leukocyte Infiltration in a Rat Model of Focal Cerebral Ischemia

2000 • 183 citations

Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells.

1997 • 183 citations

Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats.

1992 • 177 citations

Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets.

1986 • 172 citations

Butyrate and the colonocyte

1996 • 160 citations

Regulation of β-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System

1997 • 157 citations

Proteolysis: The proteasome: a protein-degrading organelle?

1995 • 155 citations

Control of gene expression by proteolysis

1996 • 145 citations

The role of butyrate in human colonic epithelial cells: an energy source or inducer of differentiation and apoptosis?

1996 • 133 citations

Dietary fructooligosaccharide, xylooligosaccharide and gum arabic have variable effects on cecal and colonic microbiota and epithelial cell proliferation in mice and rats.

1995 • 131 citations

Effect of organic acid absorption on bicarbonate transport in rat colon

1979 • 123 citations

Novel IκBα Proteolytic Pathway in WEHI231 Immature B Cells

1998 • 120 citations

The ubiquitin-mediated proteolytic pathway as a therapeutic area

1997 • 113 citations

Regulation of NF-κB activity by IκB-related proteins in adenocarcinoma cells

1999 • 113 citations

Apoptosis Cascade Proteins Are Regulated In Vivo by High Intracolonic Butyrate Concentration: Correlation With Colon Cancer Inhibition

2001 • 107 citations

Fiber-derived butyrate and the prevention of colon cancer

1997 • 90 citations

Butyrate, aspirin and colorectal cancer

1996 • 79 citations

Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells

1998 • 77 citations

Modulation of mucosal cell proliferation in the intestine of rats fed a wheat bran diet

1983 • 74 citations

The inhibitory action of butyrate on lipopolysaccharide-induced nitric oxide production in RAW 264.7 murine macrophage cells

2000 • 71 citations

The Ubiquitin-Proteasome Pathway and Serine Kinase Activity Modulate Adenomatous Polyposis Coli Protein-mediated Regulation of β-Catenin-Lymphocyte Enhancer-binding Factor Signaling

1999 • 70 citations

Regulation of c‐myc expression by sodium butyrate in the colon carcinoma cell line Caco‐2

1993 • 68 citations

Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells

1998 • 68 citations

Stretch-induced growth in chicken wing muscles: nerve-muscle interaction in muscular dystrophy

1984 • 67 citations

Butyrate metabolism in the terminal ileal mucosa of patients with ulcerative colitis

1995 • 63 citations

Untitled

1998 • 58 citations

Regulation of c-fos Expression by Sodium Butyrate in the Human Colon Carcinoma Cell Line Caco-2

1993 • 52 citations

Butyrate from bacterial fermentation of germinated barley foodstuff preserves intestinal barrier function in experimental colitis in the rat model

1999 • 50 citations

Butyrate regulates E-cadherin transcription, isoform expression and intracellular position in colon cancer cells

2000 • 48 citations

Lactacystin, a Proteasome Inhibitor : Discovery and its Application in Cell Biology

2000 • 45 citations

Withdrawal of butyrate from the colonic mucosa triggers ”mass apoptosis" primarily in the G 0 /G 1 phase of the cell cycle

1996 • 41 citations

Effect of dietary fiber on colonic cell proliferation and its relationship to colon carcinogenesis

1987 • 40 citations

Wheat Bran Decreases Aberrant Crypt Foci, Preserves Normal Proliferation, and Increases Intraluminal Butyrate Levels in Experimental Colon Cancer

1999 • 40 citations

High-level expression of IkB-b in the surface epithelium of the colon: in vitro evidence for an immunomodulatory role

1999 • 40 citations

Maintaining gut homeostasis: The butyrate–NF-κB connection

2000 • 33 citations

Protein kinase C–dependent activation of NF-κB in enterocytes is independent of IκB degradation

1999 • 33 citations

Modulation of glutathione level during butyrate-induced differentiation in human colon derived HT-29 cells.

1997 • 29 citations

Butyrate

1997 • 29 citations

Are Dietary Fiber-Induced Alterations in Colonic Epithelial Cell Proliferation Predictive of Fiber's Effect on Colon Cancer?

2000 • 24 citations

Butyrate regulates gene expression of the plasminogen activating system in colon cancer cells

1995 • 18 citations

Inhibitory effect of microfibril wheat bran on azoxymethane-induced colon carcinogenesis in CF1 mice

1999 • 16 citations

Enhanced apoptosis in transformed human lung fibroblasts after exposure to sodium butyrate

1996 • 14 citations

mdr 1 gene-expression and villin synthesis in a colon cancer cell line differentiated by sodium butyrate.

1993 • 9 citations

Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects IκBα turnover

1999 • 5 citations

Anion transport in the colon

1982 • 5 citations