Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies

1981 • 1,664 citations

Pediatric risk of mortality (PRISM) score

1988 • 1,395 citations

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

1987 • 836 citations

Antigen unmasking on formalin‐fixed, paraffin‐embedded tissue sections

1993 • 733 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.

1987 • 467 citations

Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.

1991 • 428 citations

Double-blind, Placebo-controlled Trial of Antithrombin III Concentrates in Septic Shock With Disseminated Intravascular Coagulation

1993 • 379 citations

Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease

1999 • 374 citations

4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease

1999 • 319 citations

Recombinant Tissue Plasminogen Activator Treatment in Two Infants With Fulminant Meningococcemia

1995 • 316 citations

Increased Tissue Thromboplastin Activity in Monocytes of Patients with Meningococcal Infection: Related to an Unfavourable Prognosis

1983 • 311 citations

Time Course of Hemostatic Abnormalities in Sepsis and its Relation to Outcome

1993 • 310 citations

Human Protein C Receptor Is Present Primarily on Endothelium of Large Blood Vessels

1997 • 288 citations

Coagulation system and platelets are fully activated in uncomplicated sepsis

2000 • 269 citations

Treatment of Homozygous Protein C Deficiency and Neonatal Purpura Fulminans with a Purified Protein C Concentrate

1991 • 261 citations

Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans

1997 • 235 citations

Disseminated Intravascular Coagulation

1999 • 233 citations

An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans–associated meningococcemia

2000 • 189 citations

Emergency management of meningococcal disease

1999 • 186 citations

Direct detection of activated protein C in blood from human subjects

1992 • 179 citations

Plasma Levels of Endothelial Cell Protein C Receptor Are Elevated in Patients With Sepsis and Systemic Lupus Erythematosus: Lack of Correlation With Thrombomodulin Suggests Involvement of Different Pathological Processes

1998 • 172 citations

The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide a in systemic meningococcal disease

1989 • 172 citations

Postinfectious purpura fulminans caused by an autoantibody directed against protein S

1995 • 163 citations

Identification of functional endothelial protein C receptor in human plasma.

1997 • 158 citations

Thrombomodulin structure and function.

1997 • 158 citations

Plasminogen activator inhibitor 1 and 2, alpha-2-antiplasmin, plasminogen, and endotoxin levels in systemic meningococcal disease

1990 • 155 citations

Epidemic Meningococcemia and Purpura Fulminans with Induced Protein C Deficiency

1993 • 154 citations

Direct detection of activated protein C in blood from human subjects

1992 • 151 citations

Thrombomodulin Structure and Function

1997 • 149 citations

Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils

1992 • 147 citations

Protein C, protein S and C4b-binding protein in severe infection and septic shock.

1991 • 145 citations

Meningococcemia and purpura fulminans in adults: acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates

1990 • 138 citations

The Relationship between Plasminogen Activator Inhibitor-1 and Proinflammatory and Counterinflammatory Mediators in Children with Meningococcal Septic Shock

1996 • 131 citations

The Soluble Endothelial Protein C Receptor Binds to Activated Neutrophils: Involvement of Proteinase-3 and CD11b/CD18

2000 • 128 citations

Validation of the Glasgow Meningococcal Septicemia Prognostic Score

1991 • 127 citations

Endothelial Protein C Receptor

1999 • 115 citations

The Protein C Pathway: New Insights

1997 • 114 citations

The Influence of Capsulation and Lipooligosaccharide Structure on Neutrophil Adhesion Molecule Expression and Endothelial Injury by Neisseria meningitidis

1996 • 109 citations

Protein C, Protein S and c4b-Binding Protein in Severe lnfection and Septic Shock

1991 • 107 citations

Rapid diagnosis of acute meningococcal infections by needle aspiration or biopsy of skin lesions.

1993 • 107 citations

Pathogenesis of Cutaneous Lesions in Acute Meningococcemia in Humans: Light, Immunofluorescent, and Electron Microscopic Studies of Skin Biopsy Specimens

1976 • 96 citations

Protein C in the treatment of coagulopathy in meningococcal disease

1998 • 95 citations

Plasma tissue factor and tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation

1997 • 86 citations

Age-related Differences in Outcome and Severity of DIC in Children with Septic Shock and Purpura

1996 • 84 citations

Current Drug Treatment Strategies for Disseminated Intravascular Coagulation

1998 • 84 citations

Pathophysiology of meningococcal sepsis in children

1998 • 63 citations

Increased plasma levels of soluble thrombomodulin in patients with sepsis and organ failure

1995 • 62 citations

Increased circulating thrombomodulin in children with septic shock

1998 • 54 citations

Types 1 and 2 plasminogen activator inhibitor and tumor necrosis factor alpha in patients with sepsis.

1990 • 51 citations

Protein S and C alterations in acutely III patients

1991 • 45 citations

Endothelial Cell Injury, as Quantified by the Soluble Thrombomodulin Level, Predicts Sepsis/Multiple Organ Dysfunction Syndrome after Blunt Trauma

1998 • 40 citations

Disseminated intravascular coagulation and purpura fulminans secondary to infection

2000 • 39 citations

Types 1 and 2 Plasminogen Activator lnhibitor and Tirmor Necrosis Factor Alpha in Fatients with Sepsis

1990 • 39 citations

Induction of human endothelial tissue factor expression byNeisseria meningitidis: the influence of bacterial killing and adherence to the endothelium

1997 • 39 citations

Two ELISA's for measurement of protein S, and their use in the laboratory diagnosis of protein S deficiency

1990 • 38 citations

The Role of Neutrophil Elastase in Human Pulmonary Artery Endothelial Cell Injury

1997 • 35 citations

Reduction of the anticoagulant activity of glycosaminoglycans on the surface of the vascular endothelium by endotoxin and neutrophils: Evaluation by an amidolytic assay

1992 • 34 citations

Endothelial Adhesion Molecule Expression and Its Inhibition by Recombinant Bactericidal/Permeability-Increasing Protein Are Influenced by the Capsulation and Lipooligosaccharide Structure ofNeisseria meningitidis

1999 • 33 citations

Plasma tissue factor and tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation

1996 • 28 citations

Severe Protein C Deficiency in Congenital Thrombotic Disease – Description of an Immunoenzymological Assay for Protein C Determination

1985 • 15 citations

Enzyme linked immunosorbent assay for measuring antithrombin III.

1989 • 10 citations

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