A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

The Atlas of Mouse Development

1992 • 1,782 citations

Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate

1971 • 1,736 citations

The atlas of mouse development

1993 • 1,427 citations

Implantation and the placenta: key pieces of the development puzzle

1994 • 1,362 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Role of tissue factor in embryonic blood vessel development

1996 • 693 citations

Inherited Thrombophilia: Part 1

1996 • 600 citations

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

1996 • 524 citations

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1982 • 434 citations

Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

1996 • 428 citations

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

1995 • 424 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 385 citations

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.

1996 • 340 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 318 citations

Invasion of the trophoblasts

1992 • 305 citations

Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos.

1989 • 287 citations

The protein C anticoagulant system: Inherited defects as basis for venous thrombosis

1995 • 286 citations

Targeted disruption of the murine tissue factor gene results in embryonic lethality

1996 • 277 citations

Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

1996 • 270 citations

Monoclonal Antibodies to a Synthetic Fibrin-Like Peptide Bind to Human Fibrin But Not Fibrinogen

1983 • 255 citations

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

1995 • 235 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

Inherited predisposition to thrombosis

1993 • 166 citations

Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation.

1997 • 154 citations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1995 • 145 citations

The first mutation identified in the thrombomodulin gene in a 45-year- old man presenting with thromboembolic disease

1995 • 95 citations

A Common Thrombomodulin Amino Acid Dimorphism Is Associated with Myocardial Infarction

1997 • 92 citations

Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity.

1998 • 83 citations

A Frequent Thrombomodulin Amino Acid Dimorphism Is not Associated with Thrombophilia

1991 • 63 citations

ACTIVATED PROTEIN C RESISTANCE DUE TO A COMMON FACTOR V GENE MUTATION IS A MAJOR RISK FACTOR FOR VENOUS THROMBOSIS

1997 • 62 citations

The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.

1993 • 57 citations

Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos

1996 • 57 citations

Thrombomodulin is preferentially expressed in Balb/c lung microvessels.

1992 • 56 citations

Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency

1993 • 53 citations

Targeting of Transgene Expression to the Vascular Endothelium of Mice by Homologous Recombination at the Thrombomodulin Locus

1996 • 52 citations

Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay.

1988 • 50 citations

Pathogenesis of Desmoplasia. I. Immunofluorescence Identification and Localization of Some Structural Proteins of Line 1 and Line 10 Guinea Pig Tumors and of Healing Wounds 1,2<xref ref-type="fn" rid="FN2">2</xref>

1984 • 41 citations

Targeted disruption of the murine tissue factor gene results in embryonic lethality

1996 • 25 citations

Thrombomodulin distribution during murine development

1993 • 23 citations

A Sensitive and Facile Assay for the Measurement of Activated Protein C Activity Levels in Vivo

1993 • 22 citations

The Absence of the Blood Clotting Regulator Thrombomodulin Causes Embryonic Lethality in Mice Before Development of a Functional Cardiovascular System

1995 • 19 citations

58 Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

1996 • 16 citations

The G1456 to T Mutation in the Thrombomodulin Gene Is Not Frequent in Patients With Venous Thrombosis

1997 • 13 citations

Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay.

1988 • 12 citations

A simple method of vascular endothelial cell isolation.

1992 • 12 citations

The first mutation identified in the thrombomodulin gene in a 45-year- old man presenting with thromboembolic disease

1995 • 8 citations

Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency

1993 • 5 citations

Production of Monoclonal Antibodies to Prostromelysin (ProMMP-3) and Establishment of a Quantitative Prostromelysin ELISA Assay

1993 • 5 citations