The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Plaque Formation in Agar by Single Antibody-Producing Cells

1963 • 2,385 citations

Further improvements in the plaque technique for detecting single antibody-forming cells.

1968 • 2,171 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

[28] Enzyme immunoassay ELISA and EMIT

1980 • 1,014 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

GENETICS OF A NEW IgVH (T15 IDIOTYPE) MARKER IN THE MOUSE REGULATING NATURAL ANTIBODY TO PHOSPHORYLCHOLINE

1974 • 247 citations

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

1978 • 211 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

INHERITANCE OF ANTIBODY SPECIFICITY

1974 • 177 citations

Idiotypic analysis of the response of C57BL/6 mice to the (4‐hydroxy‐3‐nitrophenyl)acetyl group

1977 • 171 citations

Inherited Immunoglobulin Idiotypes of the Mouse

1977 • 168 citations

EVIDENCE FOR THE LINKAGE OF THE I<scp>G</scp>CH LOCUS TO A GENE CONTROLLING THE IDIOTYPIC SPECIFICITY OF ANTI-p-AZOPHENYLARSONATE ANTIBODIES IN STRAIN A MICE

1973 • 159 citations

The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse

1983 • 151 citations

Molecular basis of a mouse strain-specific anti-hapten response

1983 • 150 citations

DNP-Lys-Ficoll: A T-Independent Antigen Which Elicits Both IgM and IgG Anti-DNP Antibody-Secreting Cells

1975 • 138 citations

Inheritance of antibody specificity V. Anti-2-phenyloxazolone in the mouse.

1978 • 116 citations

Anti-oxazolone hybridomas and the structure of the oxazolone idiotype.

1983 • 114 citations

Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. I. Genetic control of delayed-type hypersensitivity by VH and I-A-region genes.

1979 • 79 citations

Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.

1985 • 72 citations

Heavy chain variable region. Multiple gene segments encode anti-4-(hydroxy-3-nitro-phenyl)acetyl idiotypic antibodies.

1985 • 63 citations

Analysis of antibody diversity: V-D-J mRNA nucleotide sequence of four anti-GAT monoclonal antibodies. A paucigene system using alternate D-J recombinations to generate functionally similar hypervariable regions.

1983 • 59 citations

Inheritance of antibody specificity. II. Anti-(4-hydroxy-5-bromo-3-nitrophenyl) acetyl in the mouse.

1975 • 54 citations

Genetic control of the immune response to the terpolymer L‐glutamic acid⁶⁰‐L‐aIanine³⁰‐L‐tyrosme¹⁰ (GAT): II. Characterization of a cross‐reactive idiotype associated with anti‐GAT antibodies from responder and nonresponder mice

1979 • 36 citations

Fine specificity and idiotypes of early antibodies against (4-hydroxy-3-nitrophenyl)acetyl (NP).

1980 • 28 citations

Immunoglobulin diversity: analysis of the germ-line V_Hgene repertoire of the murine anti-GAT response

1983 • 24 citations

The Genes Encoding Anti-NP Antibodies in Inbred Strains of Mice

1984 • 21 citations

Heterogeneous and monoclonal helper T cells induce similar anti‐(4‐hydroxy‐3‐nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response II. Lambda light chain dominance and idiotope expression

1984 • 19 citations