Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons

Translating the Histone Code

2001 • 9,488 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

1996 • 1,272 citations

Histone modifications in transcriptional regulation

2002 • 1,200 citations

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

2001 • 1,140 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

2002 • 1,050 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

The dopamine hypothesis of reward: past and current status

1999 • 981 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation

2000 • 782 citations

Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy

1998 • 741 citations

Signal Transduction and the Control of Gene Expression

2002 • 699 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

2002 • 636 citations

Kainate, a double agent that generates seizures: two decades of progress

2000 • 633 citations

Acetylcholine: a neurotransmitter for learning and memory?

1995 • 601 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

1993 • 571 citations

Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14

2000 • 562 citations

Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

1992 • 552 citations

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

1997 • 548 citations

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

2001 • 530 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory

1999 • 520 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

Requirement of Rsk-2 for Epidermal Growth Factor-Activated Phosphorylation of Histone H3

1999 • 478 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase

1999 • 441 citations

Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation

2000 • 415 citations

Activation of immediate early genes and memory formation

1999 • 413 citations

The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures

1987 • 379 citations

D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses

1996 • 374 citations

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

1998 • 364 citations

Snf1--a Histone Kinase That Works in Concert with the Histone Acetyltransferase Gcn5 to Regulate Transcription

2001 • 364 citations

The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro

1991 • 311 citations

Signaling routes to CREM and CREB: plasticity in transcriptional activation

1999 • 304 citations

MOLECULAR GENETIC ANALYSIS OF SYNAPTIC PLASTICITY, ACTIVITY-DEPENDENT NEURAL DEVELOPMENT, LEARNING, AND MEMORY IN THE MAMMALIAN BRAIN

1997 • 299 citations

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.

1993 • 283 citations

The role of dopamine in epilepsy

1996 • 272 citations

Increased Ser-10 Phosphorylation of Histone H3 in Mitogen-stimulated and Oncogene-transformed Mouse Fibroblasts

1999 • 268 citations

Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus

1993 • 262 citations

Light induces chromatin modification in cells of the mammalian circadian clock

2000 • 259 citations

Fos Imaging Reveals Differential Patterns of Hippocampal and Parahippocampal Subfield Activation in Rats in Response to Different Spatial Memory Tests

2000 • 259 citations

Altered Histone Acetylation atGlutamate Receptor 2andBrain-Derived Neurotrophic FactorGenes Is an Early Event Triggered by Status Epilepticus

2002 • 258 citations

Phosphorylation of histone H3 correlates with transcriptionally active loci

2000 • 234 citations

D ₂ dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons

1999 • 222 citations

Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine

1995 • 212 citations

Hippocampus as a memory map: Synaptic plasticity and memory encoding by hippocampal neurons

1999 • 198 citations

Increased Histone Acetyltransferase and Lysine Acetyltransferase Activity and Biphasic Activation of the ERK/RSK Cascade in Insular Cortex During Novel Taste Learning

2001 • 196 citations

Independent Dynamic Regulation of Histone Phosphorylation and Acetylation during Immediate-Early Gene Induction

2001 • 192 citations

ERKI/II Regulation by the Muscarinic Acetylcholine Receptors in Neurons

2000 • 182 citations

Transcriptional Induction of MKP-1 in Response to Stress Is Associated with Histone H3 Phosphorylation-Acetylation

2001 • 175 citations

Protein Synthesis-dependent and -independent Regulation of Hippocampal Synapses by Brain-derived Neurotrophic Factor

2001 • 172 citations

Follicle-stimulating Hormone Stimulates Protein Kinase A-mediated Histone H3 Phosphorylation and Acetylation Leading to Select Gene Activation in Ovarian Granulosa Cells

2001 • 162 citations

p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites

1993 • 158 citations

Mitogen-Regulated RSK2-CBP Interaction Controls Their Kinase and Acetylase Activities

2001 • 134 citations

Neuroprotective Role of Dopamine Against Hippocampal Cell Death

2000 • 126 citations

Reconstitution of recombinant chromatin establishes a requirement for histone-tail modifications during chromatin assembly and transcription

2001 • 117 citations

CBP, a transcriptional coactivator and acetyltransferase

2001 • 115 citations

Caspase inhibitors increase short‐term survival of progenitor‐cell progeny in the adult rat dentate gyrus following status epilepticus

2001 • 113 citations

Kainate-induced genes in the hippocampus: lessons from expression patterns

2001 • 111 citations

The Nucleosome: A Powerful Regulator of Transcription

1998 • 109 citations

An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis

2001 • 105 citations

Differential regulation of CENP-A and histone H3 phosphorylation in G2/M

2001 • 99 citations

Neurobiology: Second messenger dualism in neuromodulation and memory

1986 • 97 citations

Transcriptional response to cAMP in brain: Specific distribution and induction of CREM antagonists

1993 • 86 citations

Effects of full D1 dopamine receptor agonists on firing rates in the globus pallidus and substantia nigra pars compacta in vivo: tests for D1 receptor selectivity and comparisons to the partial agonist SKF 38393.

1998 • 74 citations

Induction of the mitogen‐activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12

1998 • 71 citations

Conformational Analysis of D₁ Dopamine Receptor Agonists: Pharmacophore Assessment and Receptor Mapping

1996 • 65 citations

Immediate early gene transcription and synaptic modulation

1999 • 64 citations

Phosphorylation of histone H3 during transcriptional activation depends on promoter structure

2003 • 57 citations

Metabotropic receptor stimulation coupled to weak tetanus leads to long-term potentiation and a rapid elevation of cytosolic protein kinase C activity

1993 • 54 citations

Chromatin Goes Global

2001 • 49 citations

Selective blockade of a slowly inactivating potassium current in striatal neurons by (�) 6-chloro-APB hydrobromide (SKF82958)

1998 • 43 citations

The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus

1999 • 40 citations

Dopamine D2 Receptor Signaling Controls Neuronal Cell Death Induced by Muscarinic and Glutamatergic Drugs

2002 • 33 citations

Functional aspects of the involvement of the hippocampus in behavior and memory functions

1995 • 16 citations