Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation

The language of covalent histone modifications

2000 • 8,260 citations

STATs and Gene Regulation

1997 • 3,927 citations

NF-κB: Ten Years After

1996 • 3,008 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

1964 • 2,410 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

1997 • 1,814 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

1998 • 975 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation

1999 • 701 citations

DNA methylation and chromatin modification

1999 • 641 citations

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

1999 • 630 citations

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

1996 • 623 citations

Analysis of Chromatin Structure byin VivoFormaldehyde Cross-Linking

1997 • 610 citations

In Vivo Cross-Linking and Immunoprecipitation for Studying Dynamic Protein:DNA Associations in a Chromatin Environment

1999 • 600 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation

2000 • 502 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena

1999 • 480 citations

Requirement of Rsk-2 for Epidermal Growth Factor-Activated Phosphorylation of Histone H3

1999 • 478 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

Identification of a Novel Phosphorylation Site on Histone H3 Coupled with Mitotic Chromosome Condensation

1999 • 446 citations

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo

1998 • 444 citations

The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase

1999 • 441 citations

Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3

1998 • 421 citations

Overlapping but Distinct Patterns of Histone Acetylation by the Human Coactivators p300 and PCAF within Nucleosomal Substrates

1999 • 411 citations

Expanded Lysine Acetylation Specificity of Gcn5 in Native Complexes

1999 • 371 citations

The many HATs of transcription coactivators

2000 • 342 citations

Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo

1998 • 319 citations

Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.

1995 • 318 citations

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

1992 • 297 citations

Yeast Heterochromatin: Regulation of Its Assembly and Inheritance by Histones

1998 • 286 citations

Increased Ser-10 Phosphorylation of Histone H3 in Mitogen-stimulated and Oncogene-transformed Mouse Fibroblasts

1999 • 268 citations

Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter

1999 • 251 citations

Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner.

1995 • 249 citations

Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases

1992 • 246 citations

Transcriptional control: Versatile molecular glue

1996 • 231 citations

Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation

1998 • 230 citations

MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction

1999 • 226 citations

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1996 • 217 citations

MAP Kinase-Dependent Transcriptional Coactivation by Elk-1 and Its Cofactor CBP

1996 • 196 citations

Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction

1998 • 178 citations

JIL-1

1999 • 168 citations

Affinity chromatographic purification of nucleosomes containing transcriptionally active DNA sequences

1987 • 164 citations

Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction.

1994 • 158 citations

Transcription: Gene control by targeted histone acetylation

1998 • 153 citations

Patterns of histone acetylation

1990 • 151 citations

Histone acetyltransferase complexes

1999 • 133 citations

Rapid and reversible changes in nucleosome structure accompany the activation, repression, and superinduction of murine fibroblast protooncogenes c-fos and c-myc.

1987 • 125 citations

Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP.

1996 • 120 citations

Histone deacetylases: complex transducers of nuclear signals

1999 • 109 citations

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli

1997 • 99 citations

Follicle-Stimulating Hormone Promotes Histone H3 Phosphorylation on Serine-10

1999 • 89 citations

Neither erk nor jnk/sapk map kinase subtypes are essential for histone h3/hmg-14 phosphorylation or c-fos and c-jun induction

1995 • 74 citations

[25] Analysis of histone subtypes and their modified forms by polyacrylamide gel electrophoresis

1989 • 59 citations

Gcn5p, a Transcription-related Histone Acetyltransferase, Acetylates Nucleosomes and Folded Nucleosomal Arrays in the Absence of Other Protein Subunits

1998 • 52 citations

A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes.

1994 • 46 citations

Serum stimulation of the c-fos enhancer induces reversible changes in c-fos chromatin structure.

1990 • 41 citations

Signaling to Chromatin through Histone Modifications: How Clear Is the Signal?

1998 • 36 citations

High-resolution analysis of c-fos chromatin accessibility using a novel DNase I-PCR assay

1992 • 25 citations

Follicle-Stimulating Hormone Promotes Histone H3 Phosphorylation on Serine-10

1999 • 19 citations

Serum Stimulation of the c-fos Enhancer Induces Reversible Changes in c-fos Chromatin Structure

1990 • 8 citations