Fas-mediated T cell deletion potentiates tumor antigen-specific tolerance in a mouse model of prostate cancer

The Fas Death Factor

1995 • 4,070 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Prostate cancer in a transgenic mouse.

1995 • 1,295 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Does the Immune System See Tumors as Foreign or Self?

2003 • 746 citations

Mechanisms of Immune Evasion by Tumors

2006 • 665 citations

Cancer Immunotherapy: A Treatment for the Masses

2004 • 610 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Spinning molecular immunology into successful immunotherapy

2002 • 364 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen

2005 • 279 citations

Molecular mechanisms of activated T cell death in vivo

2002 • 276 citations

Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

2006 • 234 citations

Activation-induced cell death

2001 • 180 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

Where have all the T cells gone? Mechanisms of immune evasion by tumors

1999 • 153 citations

Cancer immunotherapy: breaking the barriers to harvest the crop

2004 • 137 citations

Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen

2005 • 107 citations

CD8+ T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function

2002 • 104 citations

Defective death receptor signaling as a cause of tumor immune escape

2002 • 92 citations

Quantitation of CD8⁺T-Lymphocyte Responses to Multiple Epitopes from Simian Virus 40 (SV40) Large T Antigen in C57BL/6 Mice Immunized with SV40, SV40 T-Antigen-Transformed Cells, or Vaccinia Virus Recombinants Expressing Full-Length T Antigen or Epitope Minigenes

2000 • 88 citations

Peripheral T cell tolerance occurs early during spontaneous prostate cancer development and can be rescued by dendritic cell immunization

2004 • 80 citations

The Fas/Fas Ligand Pathway Is Important for Optimal Tumor Regression in a Mouse Model of CTL Adoptive Immunotherapy of Experimental CMS4 Lung Metastases

2003 • 76 citations

Expression of a Tolerizing Tumor Antigen in Peripheral Tissue Does Not Preclude Recovery of High-Affinity CD8+ T Cells or CTL Immunotherapy of Tumors Expressing the Antigen

2001 • 67 citations

Adoptive immunotherapy prevents prostate cancer in a transgenic animal model

1999 • 64 citations

CD8+ Tumor-Infiltrating Lymphocytes Are Primed for Fas-Mediated Activation-Induced Cell Death But Are Not Apoptotic In Situ

2001 • 58 citations

Cytotoxic T-Lymphocyte Epitope Immunodominance in the Control of Choroid Plexus Tumors in Simian Virus 40 Large T Antigen Transgenic Mice

1999 • 57 citations

CD8+ T cell tolerance and cancer immunotherapy.

2003 • 54 citations

Avoiding Tolerance Against Prostatic Antigens With Subdominant Peptide Epitopes

2001 • 51 citations

Fetal Expression of Fas Ligand Is Necessary and Sufficient for Induction of CD8 T Cell Tolerance to the Fetal Antigen H-Y during Pregnancy

2005 • 49 citations

Sequential loss of cytotoxic T lymphocyte responses to simian virus 40 large T antigen epitopes in T antigen transgenic mice developing osteosarcomas.

2000 • 49 citations

Clonal Deletion of Simian Virus 40 Large T Antigen-Specific T Cells in the Transgenic Adenocarcinoma of Mouse Prostate Mice: An Important Role for Clonal Deletion in Shaping the Repertoire of T Cells Specific for Antigens Overexpressed in Solid Tumors

2002 • 43 citations

Passive but not active CD8+ T cell-based immunotherapy interferes with liver tumor progression in a transgenic mouse model.

1998 • 38 citations

Induction of Tumor Antigen-Specific Immunity In Vivo by a Novel Vaccinia Vector Encoding Safety-Modified Simian Virus 40 T Antigen

1999 • 35 citations

Deletion is neither sufficient nor necessary for the induction of peripheral tolerance in mature CD8⁺ T cells

2006 • 33 citations

Cutting Edge: Passive But Not Active CD8+ T Cell-Based Immunotherapy Interferes with Liver Tumor Progression in a Transgenic Mouse Model

1998 • 29 citations

Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: FasL/Fas-Mediated Inhibition of CD4⁺and CD8⁺Antiviral T Cells by Viral Antigen-Positive Veto Cells

1999 • 22 citations

Characterization of the Fas Ligand/Fas-Dependent Apoptosis of Antiretroviral, Class I MHC Tetramer-Defined, CD8+ CTL by In Vivo Retrovirus-Infected Cells

2002 • 17 citations

Fas-Dependent Elimination of Nonselected CD8 Cells andlprDisease

2002 • 16 citations

Altered functional and biochemical response by CD8+ T cells that remain after tolerance

2001 • 6 citations

Apoptosis of Epitope-Specific Antiretroviral Cytotoxic T Lymphocytes via Fas Ligand–Fas Interactions

2006 • 5 citations