Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen

Cancer Statistics, 2003

2003 • 3,302 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Molecular determinants of resistance to antiandrogen therapy

2003 • 2,212 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Prostate cancer in a transgenic mouse.

1995 • 1,295 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

A history of prostate cancer treatment

2002 • 563 citations

Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

2000 • 521 citations

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

2001 • 500 citations

Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ

2002 • 466 citations

Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer

2003 • 424 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Expression of Transforming Growth Factor-β in the Rat Ventral Prostate during Castration-Induced Programmed Cell Death

1989 • 417 citations

Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence

2003 • 391 citations

T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer

2001 • 373 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene.

1993 • 319 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

CTLA-4 Blockade Reverses CD8+ T Cell Tolerance to Tumor by a CD4+ T Cell– and IL-2-Dependent Mechanism

1999 • 287 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice.

1994 • 259 citations

Augmentation of T Cell Levels and Responses Induced by Androgen Deprivation

2004 • 258 citations

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

1998 • 248 citations

Increasing Tumor Antigen Expression Overcomes “Ignorance” to Solid Tumors via Crosspresentation by Bone Marrow-Derived Stromal Cells

2002 • 239 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

Maintenance of in Vivo Tolerance by Persistence of Antigen

1992 • 209 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

Generation of Recombinant Vaccinia Viruses

2017 • 195 citations

Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness

2002 • 193 citations

Morphological and Histological Study of Castration-Induced Degeneration and Androgen-Induced Regeneration in the Mouse Prostate1

1986 • 182 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4⁺ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma

1996 • 165 citations

CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule Exocytosis

2001 • 153 citations

Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β Cells

2002 • 151 citations

TGFβ in prostate cancer: A growth inhibitor that can enhance tumorigenicity

1997 • 150 citations

Prospects for adoptive T cell therapy

1997 • 139 citations

Castration alters peripheral immune function in normal male mice.

1995 • 131 citations

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

2002 • 129 citations

Generation of Recombinant Vaccinia Viruses

2015 • 114 citations

PSA markers in prostate cancer detection

2003 • 100 citations

Multiple Components of a Complex Androgen-Dependent Enhancer

1991 • 100 citations

The stringency and magnitude of androgen-specific gene activation are combinatorial functions of receptor and nonreceptor binding site sequences.

1993 • 99 citations

In Vivo CD4+ T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions

2000 • 81 citations

An evaluation of the potential to use tumor-associated antigens as targets for antitumor T cell therapy using transgenic mice expressing a retroviral tumor antigen in normal lymphoid tissues.

1993 • 69 citations

Early castration reduces prostatic carcinogenesis in transgenic mice

1999 • 69 citations

Androgen ablation-induced programmed death of prostatic glandular cells does not involve recruitment into a defective cell cycle or p53 induction.

1995 • 68 citations

Androgen-receptor gene structure and function in prostate cancer

1996 • 63 citations

Molecular Biology of the Androgen Receptor

2000 • 50 citations

Clonal Deletion of Simian Virus 40 Large T Antigen-Specific T Cells in the Transgenic Adenocarcinoma of Mouse Prostate Mice: An Important Role for Clonal Deletion in Shaping the Repertoire of T Cells Specific for Antigens Overexpressed in Solid Tumors

2002 • 43 citations

In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy

2004 • 36 citations

Studies on the prostate and testis as immunologically privileged sites.

1977 • 35 citations

Effector CD4 Cells Are Tolerized Upon Exposure to Parenchymal Self-Antigen

2002 • 35 citations

The Stringency and Magnitude of Androgen-Specific Gene Activation are Combinatorial Functions of Receptor and Nonreceptor Binding Site Sequences

1993 • 34 citations

CD4 Cell Priming and Tolerization Are Differentially Programmed by APCs upon Initial Engagement

2002 • 34 citations

Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-α and IFN-γ expression potentials

2003 • 16 citations