The Fas/Fas Ligand Pathway Is Important for Optimal Tumor Regression in a Mouse Model of CTL Adoptive Immunotherapy of Experimental CMS4 Lung Metastases

The Fas Death Factor

1995 • 4,070 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Lymphocyte-Mediated Cytotoxicity

2002 • 1,079 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

2000 • 440 citations

The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors

1999 • 425 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

CD95(APO-1/Fas)-Mediated Apoptosis: Live and Let Die

1998 • 405 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein

1999 • 337 citations

Expression of APO‐1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium

1994 • 310 citations

Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness.

1994 • 262 citations

Fas expression and function in normal and malignant breast cell lines.

1996 • 236 citations

Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma.

1977 • 231 citations

Identification of cellular mechanisms operational in vivo during the regression of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin 2.

1987 • 211 citations

Tumor-Specific CTL Kill Murine Renal Cancer Cells Using Both Perforin and Fas Ligand-Mediated Lysis In Vitro, But Cause Tumor Regression In Vivo in the Absence of Perforin

2002 • 128 citations

Cancer Vaccines

1999 • 120 citations

Fas and Fas ligand interactions in malignant disease.

2000 • 95 citations

Caspase Dependence of Target Cell Damage Induced by Cytotoxic Lymphocytes

1998 • 91 citations

Generation of Stable CD4+and CD8+T Cell Lines from Patients Immunized withrasOncogene-Derived Peptides Reflecting Codon 12 Mutations

1997 • 88 citations

The Role of Adoptively Transferred CD8 T Cells and Host Cells in the Control of the Growth of the EG7 Thymoma: Factors That Determine the Relative Effectiveness and Homing Properties of Tc1 and Tc2 Effectors

2001 • 85 citations

Tumor Regression After Adoptive Transfer of Effector T Cells Is Independent of Perforin or Fas Ligand (APO-1L/CD95L)

1999 • 82 citations

Therapeutic Vaccination for Cancer

2000 • 74 citations

Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity.

1996 • 72 citations

IFN-γ-Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells

2000 • 72 citations

Peptide Modification or Blocking of CD8, Resulting in Weak TCR Signaling, Can Activate CTL for Fas- But Not Perforin-Dependent Cytotoxicity or Cytokine Production

1998 • 65 citations

CD95(APO-1/Fas)-Mediated Apoptosis in Normal and Malignant Liver, Colon, and Hematopoietic Cells

1998 • 56 citations

T-Cell Adoptive Therapy of Tumors: Mechanisms of Improved Therapeutic Performance

2001 • 48 citations

Differential Role of Fas/Fas Ligand Interactions in Cytolysis of Primary and Metastatic Colon Carcinoma Cell Lines by Human Antigen-Specific CD8+ CTL

2000 • 48 citations

T Cell-Mediated Tumor Rejection Displays Diverse Dependence Upon Perforin and IFN-γ Mechanisms That Cannot Be Predicted From In Vitro T Cell Characteristics

2000 • 47 citations

Regression of Extensive Pulmonary Metastases in Mice by Adoptive Transfer of Antigen-Specific CD8+ CTL Reactive Against Tumor Cells Expressing a Naturally Occurring Rejection Epitope

2001 • 47 citations

Quantitating Therapeutically Relevant T-Cell Responses to Cancer Vaccines

2001 • 22 citations