Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: FasL/Fas-Mediated Inhibition of CD4⁺and CD8⁺Antiviral T Cells by Viral Antigen-Positive Veto Cells

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Data analysis

1996 • 2,754 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Inhibition of T cell apoptosis in the rheumatoid synovium.

1997 • 474 citations

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.

1996 • 464 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies.

1981 • 386 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

Lipopolysaccharide interferes with the induction of peripheral T cell death

1995 • 240 citations

Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor- alpha secretion

1994 • 220 citations

Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

1998 • 217 citations

T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

1994 • 206 citations

Activated B cells express functional Fas ligand

1996 • 202 citations

Evasion of Cytotoxic T Lymphocyte (CTL) Responses by Nef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells

1997 • 194 citations

Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists

1996 • 189 citations

Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion.

1995 • 168 citations

Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.

1994 • 152 citations

Veto Cells

1988 • 150 citations

9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.

1993 • 124 citations

IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection: correlation with its ability to block culture-induced down-modulation of Bcl-2.

1996 • 119 citations

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

1994 • 98 citations

Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense.

1997 • 95 citations

Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen.

1984 • 90 citations

Generation of class I MHC-restricted T-T hybridomas.

1990 • 85 citations

Expression and Characterization of Human CD4: Immunoglobulin Fusion Proteins

1990 • 73 citations

Resistance to Fas-mediated Apoptosis of Peripheral T Cells in Human T Lymphocyte Virus Type I (HTLV-I) Transgenic Mice with Autoimmune Arthropathy

1997 • 63 citations

Immunodominant mink cell focus-inducing murine leukemia virus (MuLV)-encoded CTL epitope, identified by its MHC class I-binding motif, explains MuLV-type specificity of MCF-directed cytotoxic T lymphocytes.

1994 • 61 citations

Fas (CD95) expression and death-mediating function are induced by CD4 cross-linking on CD4+ T cells.

1996 • 56 citations

Fas ligand expression is restricted to nonlymphoid thymic components in situ.

1997 • 51 citations

Fas ligand deficiency in HIV disease

1997 • 48 citations

An immunodominant Kb-restricted peptide from the p15E transmembrane protein of endogenous ecotropic murine leukemia virus (MuLV) AKR623 that restores susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes

1994 • 39 citations

Antigen specific suppression of T-cell responses — the veto concept

1985 • 36 citations

Specificity of cytolytic T cells directed against AKR/Gross virus-induced syngeneic leukemias: antibodies directed against H-2K, but not against viral proteins, inhibit lysis.

1980 • 34 citations

Genetic control of the induction of cytolytic T lymphocyte responses to AKR/Gross viral leukemias. I. H-2-encoded dominant gene control.

1984 • 27 citations

Genetic control of the induction of cytolytic T lymphocyte responses to AKR/Gross viral leukemias. II. Negative control by the Fv-1 locus in AKR mice of responder H-2b haplotype.

1984 • 23 citations

Cytotoxic T Lymphocyte Responses to the Envelope Proteins of Endogenous Ecotropic and Mink Cytopathic Focus-Forming Murine Leukemia Viruses in H-2b Mice

1994 • 19 citations

Cell surface expression of cytotoxic T lymphocyte-defined, AKR/Gross leukemia virus-associated tumor antigens by normal AKR.H-2b splenic B cells.

1983 • 14 citations

Recognition of endogenous ecotropic murine leukaemia viruses by anti-AKR/Gross virus cytotoxic T lymphocytes (CTL): epitope variation in a CTL-resistant virus

1995 • 13 citations

Induction of anti-MuLV cytotoxic T lymphocytes in the AKR.H-2b and AKR.H-2b:Fv-1b mouse strains

1988 • 13 citations

Endogenous ecotropic and recombinant MCF mouse retroviral variation and escape from antiviral CTL

1996 • 11 citations

Generation of anti-AKR/gross murine leukemia virus cytotoxic T lymphocytes (CTL). An analysis of precursor CTL frequencies in the AKR.H-2b and C57BL/6 mouse strains.

1992 • 9 citations

Mechanism of nonresponsiveness to AKR/Gross leukemia virus in AKR.H-2b:Fv-1b mice. An analysis of precursor cytotoxic T lymphocyte frequencies in young versus moderately aged mice.

1991 • 9 citations

AKR.H-2b lymphocytes inhibit the secondary in vitro cytotoxic T-lymphocyte response of primed responder cells to AKR/Gross murine leukemia virus-induced tumor cell stimulation

1996 • 8 citations

Nonresponsiveness of AKR.H-2b congenic mice for anti-AKR/Gross MuLV CTL responses: involvement of inhibitory cells as defined by adoptive transfer experiments

1995 • 8 citations

Neoplastic Model for the Differentiation of a Subpopulation of Lymphocytes Bearing IgH‐1‐Linked Gene Products

1984 • 6 citations

Deleted Work

1955 • 0 citations