Lipofuscin: Fine-Structural and Biochemical Studies

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Histochemistry: Theoretical and Applied

1961 • 3,064 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

Cellular mechanisms of oxygen toxicity.

1968 • 515 citations

Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids

1969 • 487 citations

Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde

1969 • 399 citations

A COMPARATOVE ELECTRON MICROSCOPIC STUDY OF REACTIVE, DEGENERATING, REGENERATING, AND DYSTROPHIC AXONS

1967 • 392 citations

Measurement of fluorescent lipid peroxidation products in biological systems and tissues

1973 • 390 citations

Suggested mechanism for the production of malonaldehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymic production of prostaglandin endoperoxides during autoxidation

1975 • 389 citations

Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids

1976 • 356 citations

Human hepatocellular pigments and lysosomes

1960 • 354 citations

THE FINE STRUCTURE OF TESTICULAR INTERSTITIAL CELLS IN GUINEA PIGS

1965 • 343 citations

Topographic brain chemistry

1967 • 341 citations

Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium

1959 • 336 citations

Handbook of Aging and the Individual

1961 • 334 citations

THE FINE STRUCTURE OF THE LATERAL VESTIBULAR NUCLEUS IN THE RAT

1968 • 319 citations

Oxygen in the Animal Organism

1964 • 303 citations

Will antioxidant nutrients slow aging processes?

1968 • 279 citations

II. ULTRASTRUCTURE OF THE CEREBRUM*

1963 • 276 citations

Studies on the fine structure of the mammalian testis. II. The human interstitial tissue

1960 • 256 citations

STUDIES ON THE INTRACELLULAR DIGESTIVE PROCESS IN MAMMALIAN TISSUE CULTURE CELLS

1965 • 230 citations

Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse

1973 • 224 citations

The Fine Structure and Histochemistry of Prostatic Glands in Relation to Sex Hormones

1966 • 216 citations

The fine structure of young and old spinal ganglia

1955 • 216 citations

Role of Free Radicals in Mutation, Cancer, Aging, and the Maintenance of Life

1962 • 204 citations

Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

1969 • 201 citations

STUDIES ON BRAIN BIOPSIES OF PATIENTS WITH HUNTINGTONʼS CHOREA

1974 • 185 citations

THE FINE STRUCTURE OF LIPOFUSCIN AGE PIGMENT IN THE NERVOUS SYSTEM OF AGED MICE

1965 • 182 citations

AN ELECTRON MICROSCOPIC STUDY OF DYSTROPHIC AXONS IN THE GRACILE AND CUNEATE NUCLEI OF VITAMIN E-DEFICIENT RATS

1964 • 177 citations

LOCALIZATION OF ACID PHOSPHATASE IN LIPOFUSCIN GRANULES AND POSSIBLE AUTOPHAGIC VACUOLES IN INTERSTITIAL CELLS OF THE GUINEA PIG TESTIS

1968 • 172 citations

Toxicity of Ozone, Oxygen, and Radiation

1970 • 161 citations

THE CROSSLINKAGE THEORY OF AGING

1968 • 149 citations

Intracellular Localization of Lipofuscin Age Pigments in the Nervous System

1964 • 137 citations

Die Fluoreszenz tierischer Gewebe in ultraviolettem Licht

1911 • 128 citations

Effect of Centrophenoxine on the Lipofuscin Pigments in the Neurones of Senile Guinea-pigs

1966 • 116 citations

Role of Unsaturated Fatty Acids in Changes of Adipose and Dental Tissues in Vitamin E Deficiency

1945 • 114 citations

A CASE OF JUVENILE LIPIDOSIS

1963 • 113 citations

Cirrhosis of the Liver in Rats on a Deficient Diet and the Effect of Alcohol

1941 • 113 citations

Presidential Address

1974 • 110 citations

Lipofuscin pigment accumulationin the nervous system of aging mice

1968 • 109 citations

Fine structure of the lipid bodies in juvenile amaurotic idiocy

1963 • 107 citations

The relation of the formation of lipofuscin to the distribution of oxidative enzymes in the human brain

1962 • 107 citations

A histochemical method for the demonstration of fat peroxides

1949 • 102 citations

Oxygen: boon and bane.

1975 • 97 citations

The Experimental Production of Senile Pigments in the Nerve Cells of Young Rats

1960 • 95 citations

Ultrastructural age changes in hippocampal neurons, synapses and neuroglia

1973 • 95 citations

Observations on the Fine Structure of Old Age Pigment

1960 • 93 citations

Structural aspects of ageing.

1973 • 91 citations

Canine ceroid-lipofuscinosis — A model for human neuronal ceroid-lipofuscinosis and aging

1973 • 89 citations

NEUROVISCERAL STORAGE DISEASE WITH CURVILINEAR BODIES

1968 • 89 citations

Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage

1972 • 85 citations

Ultrastructural variations in the anal papillae of Aedes aegypti (L.) at different environmental salinities

1966 • 82 citations

Pathologische Histologie

1950 • 82 citations

Studies on ageing in nematodes IV. The effect of anti-oxidants on cellular damage and life span

1972 • 81 citations

Biological Antioxidant Protection against Lipid Peroxidation Damage

1970 • 79 citations

Genesis of Intracellular Pigment in the Spinal Ganglia of Senile Rats. An Electron Microscope Study

1957 • 79 citations

Fluorescent products from aging Drosophila melanogaster: An indicator of free radical lipid peroxidation damage

1974 • 77 citations

LIPOFUSCIN (AGING) PIGMENT GRANULES OF THE NEWBORN HUMAN LIVER

1969 • 76 citations

Fine structural changes in the lateral vestibular nucleus of aging rats

1974 • 76 citations

Structural aspects of aging

1962 • 76 citations

Free Radical Pathology

1971 • 69 citations

Microspectrographic studies on the yellow pigment in nerve cells

1950 • 69 citations

A case of juvenile lipidosis: Electron microscopic, histochemical and biochemical studies

1968 • 68 citations

The Properties of Isolated Human Cardiac Age Pigment. II. Chemical and Enzymatic Properties

1963 • 67 citations

Measurement and Spectral Characteristics of Fluorescent Pigments in Tissues of Rats as a Function of Dietary Polyunsaturated Fats and Vitamin E

1973 • 67 citations

Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and vitamin E deficient rats

1967 • 66 citations

THE ULTRASTRUCTURE OF ISOLATED AND IN SITU HUMAN CARDIAC AGE PIGMENT

1963 • 65 citations

Fluorescent Products and Lysosomal Components in Aging Drosophila melanogaster

1974 • 65 citations

The Amount and Distribution of Pigments in Neurons and Glia of the Cerebral Cortex. Autofluorescent and Ultrastructural Studies

1969 • 64 citations

Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats

1974 • 63 citations

Fluorescent products of lipid peroxidation: I. Structural requirement for fluorescence in conjugated schiff bases

1973 • 62 citations

Ultrastructural changes in neurons of the spinal anterior horn of ageing mice with particular reference to the accumulation of lipofuscin pigment

1974 • 61 citations

BIOLOGICAL RANCIDIFICATION

1969 • 61 citations

Formation of Fluorescent Pigment in Vitamin E Deficiency

1947 • 60 citations

DEPOSITS OF FLUORESCENT ACID-FAST PRODUCTS IN THE NERVOUS SYSTEM AND SKELETAL MUSCLES OF ADULT RATS WITH CHRONIC VITAMIN-E DEFICIENCY

1953 • 57 citations

PROGRESS OF MEDICAL SCIENCE PATHOLOGY AND BACTERIOLOGY UNDER THE CHARGE OF

1965 • 55 citations

Insect brain as a model for the study of aging

1971 • 54 citations

PATHOLOGICAL LESIONS RELATED TO DISTURBANCES OF FAT AND CHOLESTEROL METABOLISM IN MAN

1957 • 53 citations

Untersuchungen an isoliertem, unver�ndertem Lipofuscin aus Herzmuskulatur

1955 • 52 citations

Lysosomes in Uterine Involution: Intracytoplasmic Degradation of Myofilaments and Collagen

1969 • 50 citations

Occurrence of Lipofuscin as Related to Aging in the Canine and Porcine Nervous System

1967 • 48 citations

The Histochemistry and Ultrastructure of Lipid Pigment in the Adrenal Glands of Aging Mice

1967 • 46 citations

On the nature of the pigment of mitochondria and of submicroscopic particles in the hepatic cell of the guinea pig

1947 • 44 citations

Neuronal aging in cultures; An electron-microscopic study

1973 • 43 citations

OCCURRENCE AND DISTRIBUTION OF ACID-FAST PIGMENT IN THE CENTRAL NERVOUS SYSTEM*

1945 • 42 citations

Age-related changes in the fine structure and number of neurons in the brain of the housefly, Musca domestica

1972 • 40 citations

Effects of oxygen-nitrogen (1:1) at 760 torr on the life span and fine structure of drosophila melanogaster

1975 • 39 citations

Lipofuscin

1973 • 39 citations

Accumulation of lipofuscin in the myocardium of senile guinea pigs: Dissolution and removal of lipofuscin following dimethylaminoethyl p-chlorophenoxyacetate administration. An electron microscopic study

1974 • 39 citations

Natural aging and radiation-induced life shortening in Drosophila melanogaster

1972 • 38 citations

Age-associated changes in the hypothalmus of the guinea pig: Effect of dimethylaminomethyl p-chlorophenoxycyaacetate microscopic and histochemical study

1974 • 38 citations

OBSERVATIONS ON THE HISTOPHYSIOLOGY OF THE ADRENAL GLAND OF THE GOLDEN HAMSTER

1950 • 38 citations

Effect of dimethylaminoethyl p-chlorophenoxyacetate on the life span of male swiss webster albino mice

1973 • 37 citations

Electron Microscope Studies on Aging Drosophila melanogaster I. Dense Bodies

1970 • 36 citations

Procedures for the isolation of lipopigments from brain, heart and liver, and their properties: A review

1973 • 36 citations

Accumulation of Lipofuscin (Age Pigment) in Aging Skeletal Connective Tissues as Revealed by Electron Microscopy

1975 • 36 citations

Additional electron microscopic observations on two cases of Batten-Spielmeyer-Vogt disease (Neuronal ceroid-lipofuscinosis)

1971 • 34 citations

Sex hormone secretion by tumors of the adrenal cortex of mice.

1949 • 34 citations

The effects of dimethylaminoethyl p-chlorophenoxyacetate on spinal ganglia neurons and satellite cells in culture. Mitochondrial changes in the aging neurons. An electron microscope study

1974 • 33 citations

Enzymic activities of lipofuscin age pigments: Comparative histochemical and biochemical studies

1965 • 31 citations

Nature of the inclusions in the lumbosacral neurons of birds

1962 • 27 citations

Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage

1972 • 27 citations

The mode of lipofuscin removal from hypothalamic neurons

1975 • 26 citations

Senescent Changes in the Cardiac Myofiber of the House Fly, Musca Domestica. An Electron Microscopic Study

1971 • 26 citations

Pigment, abnormal mitochondria and laminar bodies in human sympathetic neurons

1967 • 25 citations

The Use of a Protozoan for Studies on Ageing

1962 • 23 citations

Der Einflu� des Centrophenoxins auf das Alterspigment in Satellitenzellen und Neuronen der Spinalganglien seniler Ratten

1971 • 22 citations

The use of a protozoan for studies on ageing. III. Similarities between young overfed and old normally fed Tokophrya infusionum: a light and elctron microscope study.

1962 • 21 citations

Critical re-examination of the premature aging concept in progeria: A light and electron microscopic study

1973 • 20 citations

Electron microscopical appearance of neuronal lipofuscin using different preparative techniques including freeze-etching

1972 • 19 citations

HISTOCHEMICAL LOCALIZATION OF RESPIRATORY AND OTHER HYDROLYTIC ENZYMES IN NEURONAL LIPOPIGMENT (LIPOFUSCIN) IN OLD GUINEA PIGS.

1963 • 19 citations

Selected enzymic studies of lipofuscin granules isolated from bovine cardiac muscle

1963 • 19 citations

Vermehrung von Lipofuscin in der Leber als Folge von Phenacetinabusus

1967 • 18 citations

Lipofuscin turnover in the frog brain

1966 • 18 citations

Beiträge zur Frage nach der Ursache des Todes

1914 • 18 citations

Factors influencing the formation of ceroid in the livers of choline-deficient rats

1953 • 18 citations

Investigations on experimentally produced age-pigment in the nervous system

1968 • 14 citations

CELLULAR AGING

1967 • 14 citations

Histochemical studies on the distribution of ?-glucuronidase and succinic dehydrogenase in young and old spinal ganglion cells of the rat

1962 • 13 citations

Hyperoxia and formation of chromolipoid pigments

1962 • 10 citations

Entwicklung und Umwandlung lysosomaler Funktionsformen unter besonderer Ber�cksichtigung des glatten endoplasmatischen Reticulum

1967 • 10 citations

Untersuchungen über die mengenmäßige Verteilung von Lipofuszin und Vitamin-E-Mangel-Pigment in Nervenzellen von Ratten verschiedener Altersstufen

1967 • 9 citations

Ueber das Pigment der Hämochromatose des Darmes

1900 • 7 citations

[Studies on the quantitative distribution of lipofuscin and vitamin E deficiency-pigment in nerve cells of rats of various age groups].

1967 • 7 citations

EFFECTS OF OVARIAN HORMONES UPON UTERINE PIGMENTATION IN VITAMIN E‐DEFICIENT RATS

1949 • 6 citations

Early Deposition of Ceroid in Kupffer Cells of Mice Fed Hepatic Necrogenic Diets.

1963 • 6 citations

Some historic and electron microscopic observations on the aged beagle pancreas

1972 • 5 citations

Ceroid in the Products of Conception of Normal and Vitamin E-deficient Rats

1971 • 5 citations

[Fluorescent acidfast substances in the nervous system of adult rats in chronic vitamin E deficiency].

1952 • 5 citations

Further Observations on the Histology and Function of the Mammalian Sympathetic Ganglia

1889 • 4 citations

An Ultrastructural Study of the Lateral Vestibular Nucleus in the Rat: Changes in Glial Cells Following Partial Deafferentation

1973 • 3 citations