Irreversible Inhibition of Mitochondrial Complex I by 1‐Methyl‐4‐Phenylpyridinium: Evidence for Free Radical Involvement

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Anatomic and Disease Specificity of NADH CoQ₁ Reductase (Complex I) Deficiency in Parkinson's Disease

1990 • 676 citations

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

1989 • 445 citations

A large kindred with autosomal dominant Parkinson's disease

1990 • 411 citations

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.

1986 • 404 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

[40] Preparations of succinate—cytochrome c reductase and the cytochrome b-c1 particle, and reconstitution of succinate-cytochrome c reductase

1967 • 223 citations

Interaction of 1‐Methyl‐4‐Phenylpyridinium Ion (MPP⁺) and Its Analogs with the Rotenone/Piericidin Binding Site of NADH Dehydrogenase

1991 • 214 citations

MPTP: A neurotoxin producing a parkinsonian syndrome

1987 • 146 citations

[43] Preparation and properties of DPNH-coenzyme Q reductase (complex I of the respiratory chain)

1967 • 135 citations

Twin studies and the genetics of Parkinson's disease—a reappraisal

1990 • 129 citations

The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase

1984 • 127 citations

The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase

1987 • 107 citations

Mitochondria. A practical approach

1988 • 96 citations

The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals

1985 • 96 citations

Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion(MPP+): Reductive activation by NADPH cytochrome P-450 reductase

1986 • 89 citations

1-methyl-4-phenylpyridine (MPP+) induces oxidative stress in the rodent

1986 • 88 citations

Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a “redox cycling” mechanism in MPTP neurotoxicity

1987 • 74 citations

Ascorbic acid reduces the dopamine depletion induced by MPTP

1985 • 64 citations

Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity by the antioxidant ascorbic acid

1985 • 61 citations

Chemically induced Parkinson's disease: Intermediates in the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the 1-methyl-4-phenyl-pyridinium ion

1987 • 36 citations

Chemically induced parkinson's disease II: Intermediates in the oxidation and reduction reactions of the 1-methyl-4-phenyl-2,3-dihydropyridinium ion and its deprotonated form

1989 • 16 citations