Mdmx as an essential regulator of p53 activity

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

2004 • 4,416 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

2002 • 982 citations

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

2002 • 803 citations

A Dynamic Role of HAUSP in the p53-Mdm2 Pathway

2004 • 644 citations

MDMX: a novel p53-binding protein with some functional properties of MDM2.

1996 • 624 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

2001 • 505 citations

The Genetic Program of Hematopoietic Stem Cells

2000 • 422 citations

MDM2, an introduction.

2003 • 387 citations

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

1998 • 378 citations

Zebrafish as a Model Organism for the Identification and Characterization of Drugs and Genes Affecting p53 Signaling

2002 • 370 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

2003 • 355 citations

The MDM2 RING-finger domain is required to promote p53 nuclear export

2000 • 352 citations

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

2000 • 330 citations

MDM2 interacts with MDMX through their RING finger domains

1999 • 319 citations

Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

2004 • 305 citations

Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

2002 • 305 citations

Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein

1999 • 282 citations

Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex

2000 • 274 citations

Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53

2002 • 260 citations

Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

1999 • 246 citations

MDM2 Promotes Ubiquitination and Degradation of MDMX

2003 • 242 citations

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1997 • 236 citations

mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation

2003 • 234 citations

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

2001 • 230 citations

MdmX Protects p53 from Mdm2-Mediated Degradation

2000 • 212 citations

Why Is p53 Acetylated?

2001 • 211 citations

mdmx is a negative regulator of p53 activity in vivo.

2002 • 188 citations

Identification of a cryptic nucleolar-localization signal in MDM2

2000 • 186 citations

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1999 • 182 citations

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

2005 • 181 citations

DNA Damage-induced MDMX Degradation Is Mediated by MDM2

2003 • 163 citations

Isolation and Identification of the Human Homolog of a New p53-Binding Protein, Mdmx

1997 • 151 citations

p53-independent functions of MDM2.

2003 • 148 citations

Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53.

2001 • 147 citations

Hdmx Protein Stability Is Regulated by the Ubiquitin Ligase Activity of Mdm2

2003 • 146 citations

Hdmx Stabilizes Mdm2 and p53

2000 • 145 citations

MDM2 and MDMX bind and stabilize the p53-related protein p73

1999 • 132 citations

dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53

2004 • 117 citations

Critical Contribution of the MDM2 Acidic Domain to p53 Ubiquitination

2003 • 116 citations

A Novel MDMX Transcript Expressed in a Variety of Transformed Cell Lines Encodes a Truncated Protein with Potent p53 Repressive Activity

1999 • 113 citations

Critical Role for a Central Part of Mdm2 in the Ubiquitylation of p53

2003 • 109 citations

Inhibition of p53 degradation by Mdm2 acetylation

2004 • 106 citations

MDM2 and MDMX can interact differently with ARF and members of the p53 family

2001 • 97 citations

A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein

1997 • 87 citations

Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target

2003 • 86 citations

p63 and p73 are not required for the development and p53-dependent apoptosis of T cells

2004 • 82 citations

Hdmx Recruitment into the Nucleus by Hdm2 Is Essential for Its Ability to Regulate p53 Stability and Transactivation

2002 • 81 citations

DNA Damage Induces MDMX Nuclear Translocation by p53-Dependent and -Independent Mechanisms

2002 • 80 citations

Mdmx and Mdm2: Brothers in Arms?

2004 • 78 citations

Regulation of p63 Function by Mdm2 and MdmX

2001 • 75 citations

p76MDM2 Inhibits the Ability of p90MDM2to Destabilize p53

2000 • 71 citations

MdmX Binding to ARF Affects Mdm2 Protein Stability and p53 Transactivation

2001 • 68 citations

Hdmx and Mdm2 can repress transcription activation by p53 but not by p63

2001 • 63 citations

MDMX Inhibits the p300/CBP-Mediated Acetylation of p53

2002 • 61 citations

MDM2 and Its Splice Variant Messenger RNAs: Expression in Tumors and Down-Regulation Using Antisense Oligonucleotides

2004 • 51 citations

The Organization and Expression of themdm2Gene

1996 • 47 citations

Multiple Murine Double Minute Gene 2 (MDM2) Proteins Are Induced by Ultraviolet Light

1999 • 46 citations

Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells

2003 • 42 citations

MDM4 (MDMX) Overexpression Enhances Stabilization of Stress-induced p53 and Promotes Apoptosis

2004 • 39 citations

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice

1999 • 38 citations

MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts

2002 • 37 citations

Genomic organization of the mouse double minute 2 gene

1996 • 23 citations

Organization, expression, and localization of the murine mdmx gene and pseudogene

2001 • 20 citations