Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice

1993 • 537 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

1994 • 512 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

mdm-2 Inhibits the G₁ Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

1996 • 354 citations

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

1993 • 347 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

1996 • 272 citations

The human MDM-2 oncogene is overexpressed in leukemias

1993 • 253 citations

The human MDM-2 oncogene is overexpressed in leukemias

1993 • 240 citations

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1997 • 236 citations

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1996 • 234 citations

Alterations of thep53, Rb andMDM2 genes in osteosarcoms

1996 • 190 citations

Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.

1996 • 175 citations

The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain

1996 • 170 citations

The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin

1994 • 164 citations

Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2.

1993 • 139 citations

Physical and functional interaction between wild-type p53 and mdm2 proteins.

1994 • 135 citations

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

1993 • 128 citations

MDM2 gene amplification in bone and soft‐tissue tumors: Association with tumor progression in differentiated adipose‐tissue tumors

1995 • 124 citations

Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest.

1992 • 123 citations

The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

1994 • 92 citations

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

1996 • 89 citations

The mdm-2 Oncogene Can Overcome Wild-Type p53 Suppression of Transformed Cell Growth

1993 • 84 citations

Twelve amplified and expressed genes localized in a single domain in glioma

1996 • 79 citations

p53 and MDM2 Expression in Oral Squamous Cell Carcinoma

1996 • 47 citations

The Organization and Expression of themdm2Gene

1996 • 47 citations

Physical and Functional Interaction between Wild-Type p53 and mdm2 Proteins

1994 • 41 citations

Genomic organization of the mouse double minute 2 gene

1996 • 23 citations