Treatment with an Estrogen Receptor Ligand Is Neuroprotective in Experimental Autoimmune Encephalomyelitis

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

2002 • 15,184 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy

2004 • 4,391 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Mechanisms of Estrogen Action

2001 • 1,945 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 1,836 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 • 1,680 citations

Rate of Pregnancy-Related Relapse in Multiple Sclerosis

1998 • 1,463 citations

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

2001 • 1,377 citations

Molecular Determinants for the Tissue Specificity of SERMs

2002 • 1,114 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

Neuroprotection by estradiol

2001 • 922 citations

A Gender Gap in Autoimmunity

1999 • 856 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

1997 • 769 citations

Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS

1999 • 728 citations

Experimental autoimmune encephalomyelitis repressed by microglial paralysis

2005 • 711 citations

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women

1988 • 708 citations

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

1995 • 612 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Estrogen receptor alpha , not beta , is a critical link in estradiol-mediated protection against brain injury

2001 • 539 citations

Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration

2003 • 469 citations

Brain atrophy in clinically early relapsing–remitting multiple sclerosis

2002 • 456 citations

Estrogen Prevents the Lipopolysaccharide-Induced Inflammatory Response in Microglia

2001 • 454 citations

The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine Systems

1998 • 431 citations

Treatment of multiple sclerosis with the pregnancy hormone estriol

2002 • 429 citations

Oestrogen receptors – an overview

1999 • 383 citations

Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes

2004 • 378 citations

Pregnancy is associated with a lower risk of onset and a better prognosis in multiple sclerosis

1995 • 356 citations

Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissuesin Vivothrough the Use of an ERα-Selective Ligand

2002 • 349 citations

Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two Different Inbred Mouse Strains

2001 • 336 citations

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

2003 • 306 citations

Grey Matter Pathology in Multiple Sclerosis

2005 • 290 citations

Estrogen Protects against Global Ischemia-Induced Neuronal Death and Prevents Activation of Apoptotic Signaling Cascades in the Hippocampal CA1

2002 • 284 citations

Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response.

1997 • 282 citations

Axon Loss in the Spinal Cord Determines Permanent Neurological Disability in an Animal Model of Multiple Sclerosis

2002 • 276 citations

IL-12, TNF-α, and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times

2001 • 272 citations

Role of astroglia in estrogen regulation of synaptic plasticity and brain repair

1999 • 266 citations

Estriol ameliorates autoimmune demyelinating disease

1999 • 266 citations

Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory

2000 • 265 citations

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Womenʼs Health Initiative randomized controlled trial

2003 • 264 citations

Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Estriol

2003 • 259 citations

Estrogen Treatment Down-Regulates TNF-α Production and Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Cytokine Knockout Mice

2001 • 259 citations

Pathogenesis of tissue injury in MS lesions

1999 • 252 citations

Minireview: Neuroprotective Effects of Estrogen—New Insights into Mechanisms of Action

2001 • 239 citations

Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) α Activity by ERβ in the Uterus

2003 • 227 citations

Estrogen induces a potent suppression of experimental autoimmune encephalomyelities and collagen-induced arthritis in mice

1994 • 218 citations

Localization of estrogen receptor ?-immunoreactivity in astrocytes of the adult rat brain

1999 • 215 citations

Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. The Women's Health Initiative Randomized Controlled Trial

2004 • 213 citations

Neuronal Damage in Autoimmune Neuroinflammation Mediated by the Death Ligand TRAIL

2005 • 212 citations

Female sex steroids: effects upon microglial cell activation

2000 • 209 citations

A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis

1997 • 187 citations

Role of oestrogen receptors α and β in immune organ development and in oestrogen‐mediated effects on thymus

2001 • 182 citations

Cellular and Molecular Mechanisms of Estrogen Regulation of Memory Function and Neuroprotection Against Alzheimer's Disease: Recent Insights and Remaining Challenges

2001 • 177 citations

Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury

2001 • 166 citations

The Protective Effect of 17β-Estradiol on Experimental Autoimmune Encephalomyelitis Is Mediated through Estrogen Receptor-α

2003 • 166 citations

Age and stage dependency of estrogen receptor expression by lymphocyte precursors

2001 • 165 citations

Investigative Models for Determining Hormone Therapy‐Induced Outcomes in Brain: Evidence in Support of a Healthy Cell Bias of Estrogen Action

2005 • 164 citations

Gray and white matter volume changes in early RRMS

2005 • 163 citations

Estrogen inhibition of EAE involves effects on dendritic cell function

2002 • 162 citations

Neuroprotective Effects of Estrogens on Hippocampal Cells in Adult Female Rats After Status Epilepticus

2000 • 161 citations

Differential Mechanisms of Neuroprotection by 17 β-Estradiol in Apoptotic versus Necrotic Neurodegeneration

2001 • 158 citations

Neurogenesis and Neuroprotection Induced by Peripheral Immunomodulatory Treatment of Experimental Autoimmune Encephalomyelitis

2005 • 147 citations

17β-Estradiol Differentially Regulates Blood-Brain Barrier Permeability in Young and Aging Female Rats

2004 • 146 citations

Estradiol Attenuates Programmed Cell Death after Stroke-Like Injury

2003 • 145 citations

Estrogen Receptor α Mediates Estrogen’s Immune Protection in Autoimmune Disease

2003 • 142 citations

Activation of Microglial Poly(ADP-Ribose)-Polymerase-1 by Cholesterol Breakdown Products during Neuroinflammation

2003 • 141 citations

Estrogen attenuated markers of inflammation and decreased lesion volume in acute spinal cord injury in rats

2005 • 140 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 139 citations

Effects of hormone replacement therapy on cognitive performance in elderly women

2001 • 135 citations

Pregnancy and multiple sclerosis

1994 • 134 citations

Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion.

1998 • 129 citations

Oral Feeding with Ethinyl Estradiol Suppresses and Treats Experimental Autoimmune Encephalomyelitis in SJL Mice and Inhibits the Recruitment of Inflammatory Cells into the Central Nervous System

2003 • 114 citations

Multiple Sclerosis Therapeutics

2018 • 114 citations

Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis

2004 • 111 citations

Axotomy abolishes NeuN expression in facial but not rubrospinal neurons

2003 • 108 citations

Pregnancy and Multiple Sclerosis

1997 • 108 citations

Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands

2005 • 105 citations

Th1/Th2 cytokine patterns and clinical profiles during and after pregnancy in women with multiple sclerosis

2004 • 99 citations

Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST)

2005 • 94 citations

17beta‐estradiol protects oligodendrocytes from cytotoxicity induced cell death

2004 • 93 citations

Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-κB

2002 • 92 citations

Cognitive performance in surgically menopausal women on estrogen

2000 • 88 citations

17β‐estradiol attenuates glutamate‐induced apoptosis and preserves electrophysiologic function in primary cortical neurons

2004 • 87 citations

Estrogen Receptor α Signaling in Inflammatory Leukocytes Is Dispensable for 17β-Estradiol-Mediated Inhibition of Experimental Autoimmune Encephalomyelitis

2004 • 84 citations

Estrogen attenuates oxidative stress-induced apoptosis in C6 glial cells

2003 • 83 citations

Variations in cytokine mRNA expression during normal human pregnancy

2000 • 80 citations

Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation

2004 • 78 citations

Non-genomic effects of estrogens and antiestrogens

1988 • 70 citations

Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axis

2004 • 68 citations

Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology

2005 • 66 citations

Estrogen as a Neuroprotective Agent in the Treatment of Spinal Cord Injury

2003 • 65 citations

Minireview: Neuroprotective Effects of Estrogen--New Insights into Mechanisms of Action

2001 • 63 citations

Preliminary studies of cytokine secretion patterns associated with pregnancy in MS patients

2004 • 58 citations

Endogenous Estrogen Formation Is Neuroprotective in Model of Cerebellar Ataxia

2003 • 54 citations

Estrogen Therapy Fails to Alter Amyloid Deposition in the PDAPP Model of Alzheimer’s Disease

2005 • 53 citations

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome

2003 • 48 citations

Protective effects of estradiol on TRAIL-induced apoptosis in a human oligodendrocytic cell line: evidence for multiple sites of interactions

2004 • 31 citations

IL‐12, IL‐6 and IFN‐γ production by lymphocytes of pregnant women with rheumatoid arthritis remission during pregnancy

2000 • 30 citations

Pregnancy and Multiple Sclerosis

1997 • 26 citations

Estrogen replacement therapy, Alzheimer’s disease, and mild cognitive impairment

2004 • 20 citations

Grey matter pathology in multiple sclerosis

2006 • 9 citations

Estrogen attenuates oxidative stress‐induced apoptosis in C6 glial cells

2002 • 5 citations

Neuronal Damage in Autoimmune Neuroinflammation Mediated by the Death Ligand TRAIL

2012 • 3 citations

Estrogen Therapy and Risk of Cognitive Decline: Results from the Women's Estrogen for Stroke Trial (WEST)

2006 • 3 citations