Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging

2002 • 1,246 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

Estrogen Deficiency and Risk of Alzheimer's Disease in Women

1994 • 843 citations

Estrogen for Alzheimer’s disease in women

2000 • 555 citations

Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

1998 • 545 citations

Very Old Women at Highest Risk of Dementia and Alzheimer's Disease

1997 • 542 citations

Estrogen Replacement Therapy and Risk of Alzheimer Disease

1996 • 504 citations

Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats

1994 • 487 citations

Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats☆

2000 • 404 citations

Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.

1994 • 365 citations

Estrogen Enhances Performance of Female Rats during Acquisition of a Radial Arm Maze

1997 • 355 citations

A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES

1986 • 326 citations

Selective hippocampal lesions: Differential effects on performance by rats of a spatial task with preoperative versus postoperative training.

1978 • 309 citations

Estradiol facilitates performance as working memory load increases

1999 • 303 citations

Postmenopausal estrogen replacement therapy and risk of AD

1999 • 293 citations

Effects of estrogen on cognition, mood, and cerebral blood flow in AD

2000 • 292 citations

Effects of Estrogen Replacement Therapy on PET Cerebral Blood Flow and Neuropsychological Performance

1998 • 276 citations

Acetylcholine Mediates the Estrogen-Induced Increase in NMDA Receptor Binding in CA1 of the Hippocampus and the Associated Improvement in Working Memory

2001 • 262 citations

High-dose estradiol improves cognition for women with AD

2001 • 262 citations

Estrogen replacement therapy and longitudinal decline in visual memory

1997 • 260 citations

Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution

1987 • 256 citations

Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging

1998 • 248 citations

Evaluation of Estrogen Treatment in Female Patients with Dementia of the Alzheimer Type.

1994 • 248 citations

Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer’s disease: results of a placebo-controlled, double-blind, pilot study

1999 • 241 citations

The epidemiology of estrogen replacement therapy and Alzheimer's disease

1997 • 230 citations

Estrogen Improves Working But Not Reference Memory and Prevents Amnestic Effects of Scopolamine on a Radial-Arm Maze

1999 • 227 citations

Effectiveness of Estrogen Replacement in Restoration of Cognitive Function after Long-Term Estrogen Withdrawal in Aging Rats

2002 • 223 citations

Ovariectomy and 17β-estradiol modulate the levels of Alzheimer’s amyloid β peptides in brain

2000 • 221 citations

Effects of estradiol on radial arm maze performance of young and aged rats

1994 • 220 citations

Estrogen replacement improves spatial reference memory and increases hippocampal synaptophysin in aged female mice

2002 • 204 citations

Cognitive skills associated with estrogen replacement in women with Alzheimer's disease

1996 • 192 citations

Modulation of Aβ peptides by estrogen in mouse models

2001 • 172 citations

Postmenopausal Estrogen Replacement Therapy and the Risk of Alzheimer Disease

2001 • 147 citations

Ovarian Hormone Replacement to Aged Ovariectomized Female Rats Benefits Acquisition of the Morris Water Maze

2002 • 143 citations

17α-estradiol and 17β-estradiol treatments are effective in lowering cerebral amyloid-β levels in AβPPSWE transgenic mice

2002 • 122 citations

Hippocampal Aβ42 Levels Correlate with Spatial Memory Deficit in APP and PS1 Double Transgenic Mice

2002 • 114 citations

Sex Differences in the Activational Effect of ERα on Spatial Learning

1998 • 113 citations

Effects of Ovariectomy and Estrogen Treatment on Learning and Hippocampal Neurotransmitters in Mice

2002 • 110 citations

Strategies Used by Hippocampal- and Caudate-Putamen-Lesioned Rats in a Learning Task

1997 • 106 citations

Ovariectomy and 17β-estradiol modulate the levels of Alzheimer's amyloid β peptides in brain

2000 • 104 citations

Estrogen modulates spontaneous alternation and the cholinergic phenotype in the basal forebrain

1999 • 102 citations

Differential contributions of ovarian and extraovarian factors to age-related reductions in plasma estradiol and progesterone during the estrous cycle of C57BL/6J mice.

1992 • 101 citations

In mice tonic estrogen replacement therapy improves non-spatial and spatial memory in a water maze task

1999 • 78 citations

Reduced cerebrospinal fluid estradiol levels are associated with increased β-amyloid levels in female patients with Alzheimer's disease

2001 • 65 citations

Estrogen Levels Do Not Correlate With Improvement in Cognition

2003 • 56 citations

Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice

2002 • 55 citations

Long‐term deprivation of oestrogens by ovariectomy potentiates β‐amyloid‐induced working memory deficits in rats

1999 • 54 citations

Impact of Estrogen Use on Decline in Cognitive Function in a Representative Sample of Older Community-resident Women

2001 • 48 citations

Brain oestradiol and testosterone levels in Alzheimer's disease

2000 • 43 citations

In vivo effects of follicle-stimulating hormone-related synthetic peptides on the mouse estrous cycle.

1996 • 39 citations

Aβ levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice

2003 • 26 citations

Ovariectomy of young mutant amyloid precursor protein transgenic mice leads to increased mortality

2002 • 23 citations

Urinary Retention Induced by Estrogen Injections in Mice: An Analytical Model

1985 • 13 citations

Steroid-Induced Urogenital Tract Changes and Urine Retention in Laboratory Rodents

1985 • 12 citations