Nanosystems for simultaneous imaging and drug delivery to T cells

Recent advances with liposomes as pharmaceutical carriers

2005 • 4,834 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Biodegradable polymeric nanoparticles as drug delivery devices

2001 • 3,390 citations

Biodegradation and biocompatibility of PLA and PLGA microspheres

1997 • 2,481 citations

Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications

2001 • 1,514 citations

T Cell Anergy

2003 • 1,418 citations

Biodegradable nanoparticles for drug delivery and targeting

2002 • 1,283 citations

Encapsulation of Guest Molecules into a Dendritic Box

1994 • 1,152 citations

Polymers for the sustained release of proteins and other macromolecules

1976 • 1,127 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases

1993 • 883 citations

Dendrimer‐based metal chelates: A new class of magnetic resonance imaging contrast agents

1994 • 704 citations

Synthesis of Polyamidoamine Dendrimers Having Poly(ethylene glycol) Grafts and Their Ability To Encapsulate Anticancer Drugs

2000 • 647 citations

The Carrier Potential of Liposomes in Biology and Medicine

1976 • 576 citations

Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes.

2001 • 566 citations

Dendrimer–drug interactions

2005 • 561 citations

Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

2011 • 539 citations

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

2006 • 518 citations

Dendrimers: properties and applications.

2001 • 504 citations

Two-photon tissue imaging: seeing the immune system in a fresh light

2002 • 482 citations

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

2003 • 480 citations

The Dendritic Box: Shape-Selective Liberation of Encapsulated Guests

1995 • 455 citations

Nano-sized MRI contrast agents with dendrimer cores

2005 • 428 citations

Ligand-targeted liposomal anticancer drugs

2003 • 424 citations

Generation of Superparamagnetic Liposomes Revealed as Highly Efficient MRI Contrast Agents for in Vivo Imaging

2005 • 423 citations

Drug entrapment in liposomes

1973 • 405 citations

Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.

2000 • 401 citations

Poly(ethylene glycol)-Conjugated PAMAM Dendrimer for Biocompatible, High-Efficiency DNA Delivery

2002 • 398 citations

In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin–PLGA conjugates

2000 • 365 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Homing of liposomes to target cells

1975 • 291 citations

Tat Peptide Directs Enhanced Clearance and Hepatic Permeability of Magnetic Nanoparticles

2002 • 270 citations

Dynamic imaging of the immune system: progress, pitfalls and promise

2006 • 270 citations

Dendrimer-Based Nanoprobe for Dual Modality Magnetic Resonance and Fluorescence Imaging

2006 • 268 citations

The conjugation of proteins with polyethylene glycol and other polymers

1993 • 264 citations

Macromolecular MRI Contrast Agents with Small Dendrimers: Pharmacokinetic Differences between Sizes and Cores

2003 • 254 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

T Cell Receptor–MHC Interactions up Close

2001 • 252 citations

Magnetoliposomes

1988 • 230 citations

Biodegradation of and tissue reaction to 50:50 poly(DL‐lactide‐co‐glycolide) microcapsules

1985 • 221 citations

Advancing animal models of neoplasia through in vivo bioluminescence imaging

2002 • 211 citations

Inflammation: imaging with Tc-99m HMPAO-labeled leukocytes.

1988 • 197 citations

Tracking T cells with tetramers: new tales from new tools

2002 • 189 citations

Cell Tagging with Clinically Approved Iron Oxides: Feasibility and Effect of Lipofection, Particle Size, and Surface Coating on Labeling Efficiency

2005 • 183 citations

Antigen-specific T cell–mediated gene therapy in collagen-induced arthritis

2001 • 183 citations

Adoptive Immunotherapy of Experimental Autoimmune Encephalomyelitis Via T Cell Delivery of the IL-12 p40 Subunit

2001 • 178 citations

Folic acid-conjugated nanostructured materials designed for cancer cell targetingElectronic supplementary information (ESI) available: experimental details; selected plots and spectra. See http://www.rsc.org/suppdata/cc/b3/b307878g/

2003 • 177 citations

Dendrimers conjugates for colonic delivery of 5-aminosalicylic acid

2003 • 171 citations

TARGETING OF DRUGS: IMPLICATIONS IN MEDICINE

1981 • 170 citations

PAMAM Dendrimer Based Macromolecules as Improved Contrast Agents

2005 • 154 citations

Dendrimer-Based Nanosized MRI Contrast Agents

2004 • 142 citations

Selective MR imaging of labeled human peripheral blood mononuclear cells by liposome mediated incorporation of dextran‐magnetite particles

1993 • 139 citations

Water-soluble dendrimer-poly(ethylene glycol) starlike conjugates as potential drug carriers

1999 • 139 citations

Gene transfer into eukaryotic cells using activated polyamidoamine dendrimers

2002 • 121 citations

Evaluation of the in Vivo Biodistribution of Indium-111 and Yttrium-88 Labeled Dendrimer-1B4M-DTPA and Its Conjugation with Anti-Tac Monoclonal Antibody

1998 • 119 citations

Tumor-imaging potential of liposomes loaded with In-111-NTA: biodistribution in mice.

1983 • 115 citations

Micro-PET imaging and small animal models of disease

2003 • 107 citations

Liposomes as delivery agents for medical imaging

1996 • 103 citations

The use of 2-[18F]fluoro-2-deoxy-d-glucose as a potential in vitro agent for labelling human granulocytes for clinical studies by positron emission tomography

1992 • 102 citations

Radiolabeled liposomes for scintigraphic imaging

2000 • 91 citations

Liposomes for scintigraphic detection of infection and inflammation

1999 • 89 citations

In vivo cellular imaging of lymphocyte trafficking by MRI: A tumor model approach to cell‐based anticancer therapy

2006 • 86 citations

Distribution of activated T cells migrating through the body: a matter of life and death

1999 • 82 citations

Migration of T Cells in Vivo: Molecular Mechanisms and Clinical Implications

2001 • 75 citations

Understanding immune cell trafficking patterns via in vivo bioluminescence imaging

2002 • 70 citations

Autoimmune Disease

1993 • 63 citations

Imaging the choreography of lymphocyte trafficking and the immune response

2006 • 61 citations

Migration of naive, effector and memory T cells: implications for the regulation of immune responses

2001 • 60 citations

ADVENTURES IN TARGETING

2002 • 59 citations

Preparation, Characterization, and Biological Analysis of Liposomal Formulations of Vincristine

2005 • 59 citations

Recognition of human colon cancer by T cells transduced with a chimeric receptor gene

2000 • 55 citations

Sustained release chemotherapeutic microspheres provide superior efficacy over systemic therapy and local bolus infusions.

2002 • 45 citations

MR imaging of biodegradable polymeric microparticles: A potential method of monitoring local drug delivery

2005 • 43 citations

On the mechanism of action of doxorubicin encapsulation in nanospheres for the reversal of multidrug resistance

1996 • 42 citations

Tat Peptide-Mediated Intracellular Delivery of Liposomes

2003 • 41 citations

MHC-based diagnostics and therapeutics – clinical applications for disease-linked genes

1999 • 40 citations

Magnetic resonance and fluorescence based molecular imaging technologies

2005 • 38 citations

More Fun than a Root Canal

1993 • 36 citations

Synthesis and characterization of polymer-(multi)-peptide conjugates for control of specific cell aggregation

1998 • 33 citations

Migration and T-lymphocyte effector function

2003 • 32 citations

A nanoscopic multivalent antigen-presenting carrier for sensitive detection and drug delivery to T Cells

2007 • 29 citations

Two-Photon imaging in Intact Lymphoid Tissue

2002 • 28 citations

Biological therapies directed against cells in autoimmune disease

2006 • 28 citations

Synthesis and Biological Activity of Polyethylene Glycol−Mouse Nerve Growth Factor Conjugate

1999 • 26 citations

Whole-body analysis of T cell responses

2003 • 23 citations

Antigen-specific downregulation of T cells by doxorubicin delivered through a recombinant MHC II–peptide chimera

2001 • 23 citations

Major Histocompatibility Complex (MHC) Tetramer Technology: An Evaluation

2002 • 21 citations

Visualizing T Cell Migration in vivo

2003 • 17 citations

Binding and retention of polycationic peptides and dendrimers in the vascular wall

2003 • 11 citations

Selective in vitro labeling of white blood cells using 99m Tc-labeled liposomes

2002 • 7 citations

T-cell immunotherapy of allergic disease: the role of CD8+ T cells

2003 • 5 citations

Deleted Work

1955 • 0 citations