Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.

Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues.

1992 • 1,012 citations

Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases

1993 • 883 citations

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

1994 • 881 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.

1994 • 682 citations

Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro

1995 • 569 citations

Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis.

1991 • 557 citations

P-glycoprotein and multidrug resistance

1996 • 549 citations

Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies

1999 • 461 citations

The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway.

1990 • 444 citations

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1997 • 326 citations

Folate-mediated targeting of antineoplastic drugs, imaging agents, and nucleic acids to cancer cells

1998 • 285 citations

Gelation of liposome interior A novel method for drug encapsulation

1992 • 260 citations

Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol.

1995 • 259 citations

Doxorubicin physical state in solution and inside liposomes loaded via a pH gradient

1998 • 248 citations

Measurement of endosome pH following folate receptor-mediated endocytosis

1996 • 226 citations

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

1998 • 221 citations

Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies

1996 • 179 citations

Pharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl).

1996 • 152 citations

In vitro cytotoxicity of liposome-encapsulated doxorubicin: dependence on liposome composition and drug release

1992 • 136 citations

Self-Association of Doxorubicin and Related Compounds in Aqueous Solution

1984 • 129 citations

Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19

1994 • 123 citations

Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis.

1995 • 88 citations

Stability of liposomal doxorubicin formulations: Problems and prospects

1993 • 85 citations

Extraction of Daunorubicin and Doxorubicin and Their Hydroxyl Metabolites: Self-Association in Aqueous Solution

1978 • 80 citations

Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution.

1995 • 74 citations

Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells

1998 • 67 citations

Multi-drug resistance (MDR) activity in acute leukemia determined by rhodamine 123 efflux assay.

1995 • 59 citations

The detection of rhodamine 123 efflux at low levels of drug resistance

1996 • 43 citations

Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression.

1996 • 40 citations