Major Histocompatibility Complex (MHC) Tetramer Technology: An Evaluation

Immunobiology: the immune system in health and disease

1995 • 3,893 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells

1983 • 1,054 citations

Fundamental Immunology

1999 • 1,011 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia

1998 • 685 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

1983 • 561 citations

Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy

2001 • 535 citations

Immunobiology: The immune system in health and disease

1995 • 475 citations

Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies

1995 • 473 citations

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

1996 • 452 citations

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8⁺T Lymphocytes in Healthy Seropositive Donors

2000 • 438 citations

HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy

1999 • 417 citations

MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen

1999 • 379 citations

Adoptive Transfer of Cloned Melanoma-Reactive T Lymphocytes for the Treatment of Patients with Metastatic Melanoma

2001 • 359 citations

Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy

1999 • 350 citations

Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix.

1995 • 305 citations

Cancer Tumor antigens

1997 • 289 citations

Accessing Complexity: The Dynamics of Virus-Specific T Cell Responses

2000 • 283 citations

Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex

1998 • 281 citations

Attrition of T Cell Memory

1999 • 278 citations

A New Look at T Cells

1998 • 269 citations

Direct visualization of antigen-specific T cells: HTLV-1 Tax11–19- specific CD8⁺T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients

1998 • 237 citations

Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression

1998 • 219 citations

Enrichment and detection of live antigen-specific CD4+ and CD8+ T cells based on cytokine secretion

1999 • 199 citations

Tracking T cells with tetramers: new tales from new tools

2002 • 189 citations

Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity

2000 • 174 citations

Assays for monitoring cellular immune responses to active immunotherapy of cancer.

2001 • 167 citations

Divided we stand: Tracking cell proliferation with carboxyfluorescein diacetate succinimidyl ester

1999 • 159 citations

Establishment and Persistence of Virus‐Specific CD4⁺ and CD8⁺ T Cell Memory

1996 • 155 citations

Cutting Edge: In Situ Tetramer Staining of Antigen-Specific T Cells in Tissues

2000 • 143 citations

Tetramer-Guided Epitope Mapping: Rapid Identification and Characterization of Immunodominant CD4+ T Cell Epitopes from Complex Antigens

2001 • 136 citations

Direct Visualization of Cytokine-Producing Recall Antigen-Specific CD4 Memory T Cells in Healthy Individuals and HIV Patients

2000 • 129 citations

Identification of HLA-B27-Restricted Peptides from the Chlamydia trachomatis Proteome with Possible Relevance to HLA-B27-Associated Diseases

2001 • 124 citations

A T Cell Clone’s Avidity Is a Function of Its Activation State

2001 • 112 citations

Characteristics of virus-specific CD8⁺T cells in the liver during the control and resolution phases of influenza pneumonia

1998 • 109 citations

In Vivo Dynamics of Anti-Viral CD8 T Cell Responses to Different Epitopes

1998 • 101 citations

The dynamics of HTLV-I and the CTL response

1999 • 94 citations

Tetramer-Guided Analysis of TCR β-Chain Usage Reveals a Large Repertoire of Melan-A-Specific CD8+ T Cells in Melanoma Patients

2000 • 91 citations

Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide.

2001 • 88 citations

HLA in health and disease

2000 • 80 citations

In situ detection of virus- and tumor-specific T-cell immunity

2000 • 79 citations

Carboxyfluorescein diacetate succinimidyl ester and the virgin lymphocyte: A marriage made in heaven

1999 • 61 citations

Rapid epitope identification from complex class-II-restricted T-cell antigens

2001 • 54 citations

Efficient assembly of recombinant major histocompatibility complex class I molecules with preformed disulfide bonds

2001 • 54 citations

Competition of peptide-MHC class I tetrameric complexes with anti-CD3 provides evidence for specificity of peptide binding to the TCR complex

2000 • 52 citations

Generation and characterization of malaria-specific human CD8+ lymphocyte clones: effect of natural polymorphism on T cell recognition and endogenous cognate antigen presentationby liver cells

2000 • 51 citations

Monitoring Antigen-Specific T cells Using MHC-Ig Dimers

2000 • 51 citations

Direct Functional Analysis of Epitope-Specific CD8⁺T Cells in Peripheral Blood

2001 • 49 citations

Soluble, High-Affinity Dimers of T-Cell Receptors and Class II Major Histocompatibility Complexes: Biochemical Probes for Analysis and Modulation of Immune Responses

1999 • 48 citations

Functional Characterization of CD8+ Antigen-Specific Cytotoxic T Lymphocytes after Enrichment Based on Cytokine Secretion: Comparison with the MHC-Tetramer Technology

2000 • 42 citations

How T Cells Count

1996 • 41 citations

Cross-Recognition of Two Middle T Protein Epitopes by Immunodominant Polyoma Virus-Specific CTL

1999 • 33 citations

Immunization with tumor-associated epitopes fused to an endoplasmic reticulum translocation signal sequence affords protection against tumors with down-regulated expression of MHC and peptide transporters

2001 • 21 citations

Development and Use of Multimeric Major Histocompatibility Complex Molecules

2002 • 17 citations

Human leucocyte antigen‐A2 restricted and Mycobacterium tuberculosis 19‐kDa antigen‐specific CD8⁺ T‐cell responses are oligoclonal and exhibit a T‐cell cytotoxic type 2 response cytokine‐secretion pattern

2001 • 13 citations

The Structure of the Major Histocompatibility Complex and its Molecular Interactions

2000 • 9 citations