Adoptive Immunotherapy of Experimental Autoimmune Encephalomyelitis Via T Cell Delivery of the IL-12 p40 Subunit

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

2000 • 2,632 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer

1996 • 1,462 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

1995 • 441 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Structural basis of spectral shifts in the yellow-emission variants of green fluorescent protein

1998 • 411 citations

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

1995 • 407 citations

Visualizing the kinetics of tumor-cell clearance in living animals

1999 • 358 citations

Transgenic Monkeys Produced by Retroviral Gene Transfer into Mature Oocytes

2001 • 308 citations

Two better cell lines for making hybridomas expressing specific T cell receptors.

1989 • 300 citations

Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis

1997 • 264 citations

Adenoviral Transfer of the Viral IL-10 Gene Periarticularly to Mouse Paws Suppresses Development of Collagen-Induced Arthritis in Both Injected and Uninjected Paws

1999 • 204 citations

Tumor Necrosis Factor α and Lymphotoxin α Are Not Required for Induction of Acute Experimental Autoimmune Encephalomyelitis

1997 • 197 citations

Antigen-specific T cell–mediated gene therapy in collagen-induced arthritis

2001 • 183 citations

Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice

1996 • 180 citations

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

1997 • 180 citations

Suppression of collagen-induced arthritis by continuous administration of IL-4.

1997 • 163 citations

Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses

1999 • 151 citations

TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice.

1998 • 137 citations

Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis

1992 • 134 citations

Cytokines in Autoimmune Disorders

1998 • 128 citations

Deviation of pancreas‐infiltrating cells to Th2 by interleukin‐12 antagonist administration inhibits autoimmune diabetes

1997 • 126 citations

TGF-β1 Somatic Gene Therapy Prevents Autoimmune Disease in Nonobese Diabetic Mice

1998 • 112 citations

Targeting Rare Populations of Murine Antigen-Specific T Lymphocytes by Retroviral Transduction for Potential Application in Gene Therapy for Autoimmune Disease

2000 • 108 citations

Interleukin‐10 Suppresses the Development of Collagen Type II‐Induced Arthritis and Ameliorates Sustained Arthritis in Rats

1996 • 104 citations

Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-β1

1998 • 99 citations

Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-γ receptor-deficient mice

1998 • 97 citations

Astrocyte-Targeted Expression of IL-12 Induces Active Cellular Immune Responses in the Central Nervous System and Modulates Experimental Allergic Encephalomyelitis

2000 • 96 citations

Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40) 2

1997 • 86 citations

Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced Th2activity

1999 • 84 citations

Gene transfer through the blood–nerve barrier: NGF-engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis

1995 • 78 citations

Oral Administration of Myelin Basic Protein Is Superior to Myelin in Suppressing Established Relapsing Experimental Autoimmune Encephalomyelitis

1999 • 70 citations

Dual-Function Reporter Protein for Analysis of Gene Expression in Living Cells

1998 • 65 citations

Administration of IL-4 Prevents Autoimmune Diabetes but Enhances Pancreatic Insulitis in NOD Mice

1998 • 57 citations

Heterogeneous Effects of IL-2 on Collagen-Induced Arthritis

2000 • 56 citations

Local Delivery of TNF by Retrovirus-Transduced T Lymphocytes Exacerbates Experimental Autoimmune Encephalomyelitis

1999 • 52 citations

Alpha-interferon inhibits the development of diabetes in NOD mice.

1998 • 52 citations

Antigen-Specific T Cells Transduced with IL-10 Ameliorate Experimentally Induced Arthritis Without Impairing the Systemic Immune Response to the Antigen

2000 • 46 citations

Cloning and expression of murine IFNβ and a TNF antagonist for gene therapy of experimental allergic encephalomyelitis

1998 • 35 citations

Safety Evaluation of Recombinant Human Interleukin-4

1997 • 33 citations

Safety Evaluation of Recombinant Human Interleukin-4

1997 • 19 citations

Tighter watch urged on adenoviral vectors…

1999 • 18 citations

NIH tightens up monitoring of gene-therapy mishaps

2000 • 12 citations

Human Gene Therapy

2000 • 7 citations

Culling plans put future of red deer study in jeopardy

2000 • 4 citations

Deleted Work

1955 • 0 citations