Antigen-specific T cell–mediated gene therapy in collagen-induced arthritis

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries.

2004 • 2,484 citations

Phage antibodies: filamentous phage displaying antibody variable domains

1990 • 2,346 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer

1996 • 1,462 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Photonic detection of bacterial pathogens in living hosts

1995 • 655 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Bioluminescent indicators in living mammals

1998 • 537 citations

Visualizing the kinetics of tumor-cell clearance in living animals

1999 • 358 citations

The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

1993 • 292 citations

The role of IL-12 in the induction of organ-specific autoimmune diseases

1995 • 277 citations

Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis

1997 • 264 citations

Noninvasive Assessment of Tumor Cell Proliferation in Animal Models

1999 • 246 citations

Anti-Tumor Necrosis Factor-α Therapy of Rheumatoid Arthritis

1997 • 233 citations

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

1997 • 180 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 151 citations

Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis

1998 • 143 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 138 citations

Targeting Rare Populations of Murine Antigen-Specific T Lymphocytes by Retroviral Transduction for Potential Application in Gene Therapy for Autoimmune Disease

2000 • 108 citations

Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection.

1996 • 101 citations

Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-β1

1998 • 99 citations

T-cell-dependent pathways in rheumatoid arthritis

1997 • 81 citations

Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.

1998 • 68 citations

Expectation bias in rheumatoid arthritis clinical trials. The anti‐CD4 monoclonal antibody experience

1996 • 49 citations

Antigen-Specific T Cells Transduced with IL-10 Ameliorate Experimentally Induced Arthritis Without Impairing the Systemic Immune Response to the Antigen

2000 • 46 citations

Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice

1998 • 36 citations

Characterization of the Adjuvant Effect of IL‐12 and Efficacy of IL‐12 Inhibitors in Type II Collagen‐Induced Arthritisa

1996 • 32 citations

Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor ? and CD40 signals

1999 • 27 citations

The application of gene therapy in autoimmune diseases

2000 • 27 citations