Biological therapies directed against cells in autoimmune disease

Complement

2001 • 2,792 citations

Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis

2004 • 2,504 citations

Anesthesiology

1997 • 2,182 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Complement

2001 • 1,457 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

2003 • 1,143 citations

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

2002 • 764 citations

Lymphoid Neogenesis in Rheumatoid Synovitis

2001 • 656 citations

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

1990 • 605 citations

Treatment of Chronic Plaque Psoriasis by Selective Targeting of Memory Effector T Lymphocytes

2001 • 593 citations

A short course of BG9588 (anti–CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

2003 • 592 citations

A Novel Targeted T-Cell Modulator, Efalizumab, for Plaque Psoriasis

2003 • 584 citations

Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes

2001 • 523 citations

T Cell Activation in Rheumatoid Synovium Is B Cell Dependent

2001 • 521 citations

Efficacy and safety of rituximab in type II mixed cryoglobulinemia

2003 • 485 citations

Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator

2003 • 460 citations

Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis

2003 • 459 citations

Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases

2004 • 392 citations

Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion

2002 • 345 citations

CD3-specific antibody-induced active tolerance: from bench to bedside

2003 • 305 citations

Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells.

1991 • 278 citations

Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: Evidence for a pathogenetic role of B cells

2002 • 255 citations

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

1999 • 245 citations

Citrullination of synovial proteins in murine models of rheumatoid arthritis

2003 • 240 citations

Ectopic Germinal Center Formation in Rheumatoid Synovitis

2003 • 233 citations

Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement

2005 • 213 citations

Adhesion molecules in autoimmune disease

1996 • 194 citations

Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis.

2004 • 185 citations

CD8 T Cells Are Required for the Formation of Ectopic Germinal Centers in Rheumatoid Synovitis

2002 • 181 citations

Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion

1999 • 151 citations

Evaluation of TNF-α and IL-1 Blockade in Collagen-Induced Arthritis and Comparison with Combined Anti-TNF-α/Anti-CD4 Therapy

2000 • 119 citations

Anti-CD20 monoclonal antibody (rituximab) as an adjunct in the treatment of giant cell arteritis

2005 • 118 citations

Regulatory T cells in rheumatoid arthritis.

2005 • 100 citations

Immune Complexes Present in the Sera of Autoimmune Mice Activate Rheumatoid Factor B Cells

2000 • 82 citations

Regulatory CD8⁺T cells fine-tune the myelin basic protein-reactive T cell receptor Vβ repertoire during experimental autoimmune encephalomyelitis

2003 • 81 citations

The role of cytokines and their inhibitors in arthritis

1992 • 80 citations

Intra-articular primatised anti-CD4: efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology

1999 • 72 citations

Therapeutic use of monoclonal anti-CD4 antibody in rheumatoid arthritis.

1991 • 71 citations

HuMax-CD4

2003 • 69 citations

Percentage of anti‐CD4 monoclonal antibody‐coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens

1996 • 67 citations

Safety of rituximab in the treatment of B cell malignancies: implications for rheumatoid arthritis.

2003 • 65 citations

Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs.

1996 • 64 citations

Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice.

1993 • 64 citations

DEPLETING ANTI-CD4 MONOCLONAL ANTIBODY CURES NEW-ONSET DIABETES, PREVENTS RECURRENT AUTOIMMUNE DIABETES, AND DELAYS ALLOGRAFT REJECTION IN NONOBESE DIABETIC MICE1

2004 • 61 citations

Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial

2002 • 60 citations

Synovial tissue response to treatment with campath‐1h

1995 • 54 citations

A double‐blind, placebo‐controlled study of anti‐CD5 immunoconjugate in patients with rheumatoid arthritis

1996 • 53 citations

CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis.

2002 • 51 citations

Apoptotic Effect of Rituximab on Peripheral Blood B Cells in Rheumatoid Arthritis

2004 • 48 citations

Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody

2004 • 45 citations

Regulatory CD8+ T Cells Control Neonatal Tolerance to a Th2-Mediated Autoimmunity

2003 • 42 citations

A randomized, double blind, placebo controlled multicenter trial of murine anti-CD4 monoclonal antibody therapy in rheumatoid arthritis.

1998 • 39 citations

The role of B cells in the pathogenesis of rheumatoid arthritis.

2005 • 38 citations

A phase II study of Rituximab in rheumatoid arthritis patients with recurrent disease following haematopoietic stem cell transplantation

2004 • 37 citations

Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation

2004 • 34 citations

B cell targeted therapies.

2005 • 33 citations

Recent advances in the management of ocular complications of sjögren’s syndrome

2005 • 25 citations

Nondepleting humanized anti-CD4 monoclonal antibody in patients with refractory rheumatoid arthritis.

1998 • 23 citations

Antigen-specific T cells in rheumatoid arthritis

2003 • 22 citations

Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells

2002 • 18 citations

Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse

2003 • 18 citations

Treatment of Inflammatory and Paraproteinemic Neuropathies

2004 • 17 citations

Effective treatment of a mouse model of Sjögren's syndrome with eyedrop administration of anti‐CD4 monoclonal antibody

2004 • 16 citations

High efficacy of Rituximab in indolent HCV-related lymphoproliferative disorders associated with systemic autoimmune diseases.

2006 • 14 citations

Prevention of adjuvant arthritis by the W3/25 anti-CD4 monoclonal antibody is associated with a decrease of blood CD4+CD45RChigh T cells

2001 • 11 citations

Temporary, but Essential Requirement of CD8⁺T Cells Early in the Pathogenesis of Diabetes in BB Rats as Revealed by Thymectomy and CD8 Depletion

2003 • 11 citations

Immunologic assessment during treatment of rheumatoid arthritis with anti-CD5 immunoconjugate.

1995 • 9 citations

Autoimmunity in Thrombotic Thrombocytopenic Purpura

2005 • 8 citations

Deleted Work

1955 • 0 citations