Interleukin-1? immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: Evidence for activity-dependent release

PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY

1974 • 3,882 citations

Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor

1987 • 1,512 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.

1990 • 770 citations

Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta.

1990 • 604 citations

Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3.

1986 • 602 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Application of coupled oxidation reaction to electron microscopic demonstration of horseradish peroxidase: cobalt-glucose oxidase method

1979 • 547 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

1995 • 470 citations

Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.

1992 • 463 citations

Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism.

1990 • 462 citations

Subnuclei in the rat hypothalamic paraventricular nucleus: A cytoarchitectural, horseradish peroxidase and immunocytochemical analysis

1980 • 395 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells

1988 • 368 citations

Immunoreactive interleukin-1β localization in the rat forebrain

1990 • 343 citations

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

1987 • 342 citations

Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

1992 • 337 citations

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

1992 • 335 citations

Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide

1998 • 323 citations

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1998 • 313 citations

Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro

1988 • 286 citations

Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling

1993 • 274 citations

The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta.

1988 • 249 citations

Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat

1994 • 236 citations

Interleukin-1 β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

1990 • 233 citations

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

1990 • 221 citations

Endotoxin-induced appearance of immunoreactive interleukin-1β in ramified microglia in rat brain: A light and electron microscopic study

1995 • 193 citations

Immunocytochemical localization of the brain-specific S-100 protein in the pituitary gland of adult rat

1980 • 182 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat

1988 • 178 citations

Expression of type II nitric oxide synthase in primary human astrocytes and microglia: role of IL-1beta and IL-1 receptor antagonist.

1996 • 174 citations

Regulation by Interleukin‐1 of Nerve Growth Factor Secretion and Nerve Growth Factor mRNA Expression in Rat Primary Astroglial Cultures

1991 • 153 citations

Expression of transforming growth factor-?1 and interleukin-1? mRNA in rat brain following transient forebrain ischemia

1993 • 150 citations

Immunohistochemical localization of interleukin-1β, interleukin-1 receptor antagonist and interleukin-1β converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid

1999 • 135 citations

Global Forebrain Ischemia Results in Differential Cellular Expression of Interleukin-1β (IL-1β) and its Receptor at mRNA and Protein Level

1997 • 131 citations

Modulation of interleukin-1 and tumor necrosis factor expression by ?-adrenergic agonists in mouse ameboid microglial cells

1991 • 122 citations

Localization of Interleukin 1 Type I Receptor mRNA in Rat Brain

1994 • 119 citations

Subcellular localization of human monocyte interleukin 1: evidence for an inactive precursor molecule and a possible mechanism for IL 1 release.

1987 • 118 citations

Microglia in the neurohypophysis associate with and endocytose terminal portions of neurosecretory neurons

1989 • 118 citations

Immunoreactive glial fibrillary acidic protein in pituicytes of the rat neurohypophysis

1982 • 111 citations

An in situ hybridization study on interleukin-1β mRNA induced by transient forebrain ischemia in the rat brain

1994 • 109 citations

Simultaneous and independent release of vasopressin and oxytocin in the rat

1988 • 104 citations

Interleukin-1 binding sites on astrocytes

1993 • 96 citations

Interleukin Iβ and thioredoxin are secreted through a novel pathway of secretion

1991 • 80 citations

Effects of interleukins on plasma arginine vasopressin and oxytocin levels in conscious, freely moving rats

1991 • 80 citations

Coexisting peptides in hypothalamic neuroendocrine systems: Some functional implications

1989 • 77 citations

Recombinant interleukin-1β stimulates eicosanoid production in rat primary culture astrocytes

1989 • 74 citations

Modulation of oxytocin and vasopressin release at the level of the neurohypophysis

1991 • 71 citations

Factors governing activity-dependent structural plasticity of the hypothalamoneurohypophysial system.

1998 • 70 citations

Chapter 11 Multiple chemical messengers in hypothalamic magnocellular neurons

1986 • 59 citations

Cytoskeletal Alterations in Human Fetal Astrocytes Induced by Interleukin‐1β

1994 • 43 citations

Distribution of interleukin 1β immunoreactivity within the porcine hypothalamus

1993 • 42 citations

Rat Interleukin-1 β Binding Sites in Rat Hypothalamus and Pituitary Gland

1995 • 41 citations

Evidence for the neuronal origin of immunoreactive interleukin-1β released by rat hypothalamic explants

1996 • 38 citations

Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS

1996 • 30 citations

Influence of Interleukin‐1β on the Secretion of Oxytoxin and Vasopressin from the Isolated Rat Neurohypophysis

1990 • 26 citations

Expression of Insulin-Like Growth Factor Binding Protein-2 during Postnatal Development of the Rat Neurointermediate Pituitary

1997 • 8 citations

Presence of microglia-like cells in the neurohypophysis of normal and dehydrated rats.

1986 • 7 citations

Presence of Microglia-Like Cells in the Neurohypophysis of Normal and Dehydrated Rats

1986 • 6 citations