Anorexic But Not Pyrogenic Actions of Interleukin‐1 are Modulated by Central Melanocortin‐3/4 Receptors in the Rat

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 677 citations

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

1995 • 345 citations

Mechanisms of CNS response to systemic immune challenge: the febrile response

1997 • 335 citations

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

1998 • 279 citations

Melanocortin receptors: perspectives for novel drugs

1999 • 190 citations

Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

1998 • 186 citations

Anorexia induced by interleukin 1: involvement of corticotropin-releasing factor

1989 • 181 citations

Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion

1998 • 179 citations

Acetylation alters the feeding response to MSH and beta-endorphin

1989 • 163 citations

Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat

1996 • 153 citations

Role of central melanocortins in endotoxin-induced anorexia

1999 • 149 citations

Receptor Biology of the Melanocortins, a Family of Neuroimmunomodulatory Peptides

1996 • 142 citations

Expression of melanocortin 1 receptor in periaqueductal gray matter

1995 • 137 citations

CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat

1989 • 134 citations

Investigation of the melanocyte stimulating hormones on food intake

2000 • 124 citations

Melanocortin mediated inhibition of feeding behavior in rats

1998 • 111 citations

Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta.

1998 • 106 citations

Neuropeptide Y blocks and reverses interleukin-1β-induced anorexia in rats

1996 • 103 citations

Cytokines and anorexia: a brief overview.

1998 • 97 citations

Cytokines and Fever

1996 • 96 citations

Sites of action of IL‐1 in the development of fever and cytokine responses to tissue inflammation in the rat

1997 • 91 citations

Mechanisms of Antiinflammatory Action of the Neuroimmunomodulatory Peptide α‐MSH

1998 • 79 citations

Pharmacology of Interleukin-1 Actions in the Brain

1994 • 75 citations

Effects of alpha-MSH on sleep, behavior, and brain temperature: interactions with IL 1

1988 • 74 citations

Central administration of alpha-MSH antiserum augments fever in the rabbit

1986 • 68 citations

Stress, Stress Hormones and the Immune System

1998 • 66 citations

Hypothalamic control of feeding

1999 • 66 citations

Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC3 receptor in the regulation of food intake

2000 • 63 citations

Effects of preoptic microinjections of α-MSH on fever and normal temperature control in rabbits

1987 • 51 citations

Peptide Modulation of Fever and Inflammation within the Brain^a

1998 • 41 citations

Alpha‐melanocyte‐stimulating hormone suppresses fever and increases in plasma levels of prostaglandin E2 in the rabbit.

1992 • 39 citations

Mice deficient in interleukin-1β converting enzyme resist anorexia induced by central lipopolysaccharide

1999 • 35 citations

Antipyretic properties of centrally administered α-MSH fragments in the rabbit

1988 • 29 citations

Carboxyl-terminal tripeptide of α-melanocyte-stimulating hormone antagonizes interleukin-1-induced anorexia

1992 • 25 citations

C-reactive protein, leukocytes, and fever after central IL 1 and alpha-MSH in aged rabbits

1988 • 21 citations

Depletion of brain α-MSH alters prostaglandin and interleukin fever in rats

1990 • 20 citations

Melanocortin and leptin signaling systems: Central regulation of catabolic energy balance

1999 • 17 citations

Is the endogenous antipyretic neuropeptide α-MSH responsible for reduced fever in aged rabbits?

1987 • 13 citations

Responsiveness of rats to interleukin-1: Effects of monosodium glutamate treatment of neonates

1990 • 11 citations