Role of regulatory T cells and FOXP3 in human diseases

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Juvenile idiopathic arthritis

2007 • 1,822 citations

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

2006 • 1,535 citations

TH-17 cells in the circle of immunity and autoimmunity

2007 • 1,520 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells

2004 • 1,060 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

2005 • 825 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

2004 • 730 citations

Differentiation and function of Th17 T cells

2007 • 720 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

Natural regulatory T cells: mechanisms of suppression

2007 • 704 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

CD4+CD25+ regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid

2004 • 526 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

Defective regulatory and effector T cell functions in patients with FOXP3 mutations

2006 • 508 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

2006 • 493 citations

Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy

2004 • 492 citations

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

2006 • 474 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

The immune paradox of sarcoidosis and regulatory T cells

2006 • 433 citations

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like syndrome, and defective IL-10 expression from CD4 lymphocytes

2006 • 408 citations

Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

2004 • 395 citations

Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes

2005 • 384 citations

Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

2004 • 359 citations

CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis

2005 • 317 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

2007 • 311 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes

2007 • 279 citations

The regulation of allergy and asthma

2006 • 263 citations

FOXP3 modifies the phenotypic and functional properties of regulatory T cells

2007 • 262 citations

Regulatory T‐cell physiology and application to treat autoimmunity

2006 • 236 citations

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

2006 • 227 citations

Defective suppression of Th2 cytokines by CD4⁺CD25⁺ regulatory T cells in birch allergics during birch pollen season

2004 • 219 citations

Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production

2003 • 211 citations

CD4+CD25high regulatory T cells in human autoimmune diabetes

2005 • 202 citations

FOXP3 acts as a rheostat of the immune response

2005 • 201 citations

Regulatory T Cells in Human Autoimmune Thyroid Disease

2006 • 193 citations

Expression and functional characterization of FOXP3+CD4+ regulatory T cells in ulcerative colitis

2006 • 185 citations

The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma

2007 • 183 citations

The role of the transcription factor Foxp3 in the development of regulatory T cells

2006 • 181 citations

Proinflammatory mediator–induced reversal of CD4+,CD25+ regulatory T cell–mediated suppression in rheumatoid arthritis

2007 • 180 citations

FOXP3⁺ regulatory T cells: Current controversies and future perspectives

2006 • 130 citations

Circulating CD4⁺CD25⁺T Regulatory Cells Are Not Altered in Multiple Sclerosis and Unaffected by Disease-Modulating Drugs

2004 • 125 citations

Novel strategies for the treatment of inflammatory bowel disease: Selective inhibition of cytokines and adhesion molecules

2006 • 115 citations

An interleukin-2 receptor gamma chain mutation with normal thymus morphology.

1997 • 98 citations

Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma

2004 • 91 citations

Genetic progress towards the molecular basis of autoimmunity

2006 • 81 citations

Expression of CD103 identifies human regulatory T-cell subsets

2006 • 75 citations

Regulatory T cells in human autoimmune diseases

2006 • 74 citations

Transcription factors in autoimmunity

2003 • 58 citations

Good for Goose, but Not for Gander: IL-2 Interferes with Th17 Differentiation

2007 • 39 citations

Adaptive human regulatory T cells: myth or reality?

2006 • 35 citations

Impaired T Cell Receptor Signaling in Foxp3⁺ CD4 T Cells

2007 • 29 citations

Induction of Transplantation Tolerance via Regulatory T Cells

2006 • 21 citations

Anti‐cytokine vaccines and the immunotherapy of autoimmune diseases

2006 • 20 citations

Targeting IL-23 in autoimmunity.

2005 • 9 citations