Anti‐cytokine vaccines and the immunotherapy of autoimmune diseases

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Interleukin-17 Family Members and Inflammation

2004 • 2,340 citations

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1999 • 1,660 citations

Increased expression of interleukin 17 in inflammatory bowel disease

2002 • 1,638 citations

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

2003 • 1,280 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

2006 • 987 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

Requirement of Interleukin‐17A for Systemic Anti–Candida albicansHost Defense in Mice

2004 • 840 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Interleukin-17 promotes angiogenesis and tumor growth

2002 • 795 citations

Understanding the IL-23–IL-17 immune pathway

2005 • 759 citations

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.

1993 • 751 citations

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1999 • 723 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism

2000 • 588 citations

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice

2003 • 470 citations

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice.

1997 • 465 citations

Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response toKlebsiella pneumoniaeInfection

2003 • 452 citations

Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis

2000 • 424 citations

The molecular basis of T helper 1 and T helper 2 cell differentiation

2000 • 400 citations

High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors.

1997 • 361 citations

Interleukin-17 inhibits tumor cell growth by means of a T-cell–dependent mechanism

2002 • 348 citations

Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis

2006 • 197 citations

Neutralization of IL‐17 by active vaccination inhibits IL‐23‐dependent autoimmune myocarditis

2006 • 164 citations

Development of an anti‐IL‐17A auto‐vaccine that prevents experimental auto‐immune encephalomyelitis

2006 • 142 citations

Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells.

1995 • 127 citations

Regulatory CD4+ T cells and the control of autoimmune disease

2004 • 115 citations

Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy

2006 • 56 citations