Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Brain Dopamine and Reward

1989 • 1,899 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Tachykinins

1988 • 542 citations

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

1987 • 524 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

The tachykinin peptide family

1981 • 470 citations

Conditioned place preference as a measure of drug reward.

1989 • 456 citations

Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms ¹

1990 • 449 citations

Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

1991 • 429 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11

1984 • 376 citations

Substance P in the Nervous System

1983 • 370 citations

Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

1973 • 363 citations

The possible existence of multiple receptors for substance P

1982 • 357 citations

Tachykinin receptor types: Classification and membrane signalling mechanisms

1991 • 342 citations

Function and evolution in the NGF family and its receptors

1992 • 338 citations

Coexistence of peptides with classical neurotransmitters

1987 • 327 citations

Evidence for a projection from the lateral preoptic area and substantia innominata to the ‘mesencephalic locomotor region’ in the rat

1984 • 326 citations

A comparison of the anatomical distribution of substance P and substance P receptors in the rat central nervous system

1984 • 310 citations

Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

1985 • 297 citations

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.

1991 • 288 citations

Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section

1985 • 268 citations

Regulatory peptides from molecular biology to function.

1982 • 263 citations

Neuropeptides and neural transmission

1980 • 252 citations

Cholinergic projections to the basolateral amygdala: A combined Evans Blue and acetylcholinesterase analysis

1982 • 224 citations

The Cholinergic Hypothesis of Memory: A Review of Animal Experiments

1988 • 210 citations

Peptides as neurotransmitter candidates in the mammalian cns

1979 • 208 citations

Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain.

1986 • 206 citations

Depletion of dopamine in the striatum as an experimental model of parkinsonism: direct effects and adaptive mechanisms

1982 • 201 citations

Substance P and Neurokinins

1987 • 200 citations

Nerve growth factor stimulates the development of substance P in sensory ganglia.

1980 • 198 citations

Substance P : metabolism and biological actions

1985 • 198 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—II. Light microscopic localization in relation to catecholamine-containing neurons

1978 • 193 citations

EFFECTS OF NEUROTENSIN AND SUBSTANCE P ON PLASMA INSULIN, GLUCAGON AND GLUCOSE LEVELS.

1976 • 189 citations

β-Amyloid protein promotes neuritic branching in hippocampal cultures

1990 • 188 citations

Blood—Brain Barrier and Peptides

1985 • 186 citations

Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain

1991 • 183 citations

Angiotensin converting enzyme in rat brain visualized by quantitative in vitro autoradiography

1987 • 175 citations

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs

1987 • 175 citations

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.

1991 • 169 citations

Regulation of the activity of striatal cholinergic neurons by dopamine

1992 • 167 citations

An hypothesis on the role of glucose in the mechanism of action of cognitive enhancers

1989 • 161 citations

Afferents to Basal Forebrain Cholinergic Projection Neurons: An Update

1991 • 161 citations

Time Course of Adaptations in Dopamine Biosynthesis, Metabolism, and Release Following Nigrostriatal Lesions: Implications for Behavioral Recovery from Brain Injury

1987 • 160 citations

Growth of Pulmonary Alveolar Macrophages in vitro

1973 • 155 citations

Anatomical analysis of the involvement of mesolimbocortical dopamine in the locomotor stimulant actions ofd-amphetamine and apomorphine

1988 • 140 citations

Substance P.

1983 • 138 citations

Multiple neurokinin receptors: Recent developments

1988 • 133 citations

Substance P receptor binding sites are expressed by glia in vivo after neuronal injury.

1989 • 120 citations

Measurement of Substance P Metabolites in Rat CNS

1985 • 120 citations

A fragment of substance P with specific central activity: SP(1–7)

1982 • 119 citations

Progress in Psychobiology and Physiological Psychology, Vol. 8

1980 • 118 citations

The Psychobiology of Reinforcers

1992 • 118 citations

Behavioral analysis of the effect of substance P injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat

1985 • 116 citations

Biological activity of carbon-terminal partial sequences of substance P

1976 • 115 citations

Conditioned Place Preference: A Parametric Analysis Using Systemic Heroin Injections

1987 • 111 citations

Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: New tools for investigating neurokinin function

1991 • 109 citations

Peptidergic neurons in the basal forebrain magnocellular complex of the rhesus monkey

1989 • 108 citations

The localization of nerve growth factor‐like immunoreactivity in the adult rat basal forebrain and hippocampal formation

1992 • 106 citations

Differential effects of C- and N-terminal substance P metabolites on the release of amino acid neurotransmitters from the spinal cord: potential role in nociception

1990 • 103 citations

The Neuropharmacological Basis of Reward

1991 • 103 citations

The relationship between reinforcement and memory: Parallels in the rewarding and mnemonic effects of the neuropeptide substance P

1989 • 103 citations

Specific binding of substance P aminoterminal heptapeptide [SP(1-7)] to mouse brain and spinal cord membranes

1990 • 101 citations

Substance P and behavior: Opposite effects of N-terminal and C-terminal fragments

1983 • 100 citations

Substance P Counteracts Neurotoxin Damage on Norepinephrine Neurons in Rat Brain During Ontogeny

1982 • 97 citations

Substance P, neurotensin and enkephalin injections into the ventral tegmental area: comparative study on dopamine turnover in several forebrain structures

1989 • 90 citations

Ventral tegmental area infusion of substance P, neurotensin and enkephalin: Differential effects on feeding behavior

1986 • 89 citations

Striatonigral GABA, dynorphin, substance P and neurokinin A modulation of nigrostriatal dopamine release: evidence for direct regulatory mechanisms

1990 • 85 citations

Substance P: From extract to excitement*

1988 • 84 citations

Synthesis and Biological Properties of Enzyme‐Resistant Analogues of Substance P

1981 • 83 citations

Substance P Analog, DiMe-C7: Evidence for Stability in Rat Brain and Prolonged Central Actions

1982 • 79 citations

Substance K and substance P differentially modulate mesolimbic and mesocortical systems

1985 • 77 citations

Trophic effect of various neuropeptides on the cultured ventral spinal cord of rat embryo

1989 • 76 citations

Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

1986 • 76 citations

Restrained rats learn amphetamine-conditioned locomotion, but not place preference

1984 • 72 citations

Brain endorphins: possible role in reward and memory formation.

1979 • 69 citations

Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

1991 • 68 citations

Effects of substance P on extracellular dopamine in neostriatum and nucleus accumbens

1992 • 68 citations

Use of substance P fragments to differentiate substance P receptors of different tissues

1982 • 65 citations

Conditioned place preference in the corral: a procedure for measuring reinforcing properties of drugs

1989 • 64 citations

Recovery from unilateral 6-hydroxydopamine lesion of substantia nigra promoted by the neurotachykinin substance P1–11

1992 • 60 citations

Nerve growth factor stimulates development of substance P in the embryonic spinal cord

1981 • 60 citations

Altered Protein Tyrosine Phosphorylation in Alzheimer's Disease

1991 • 59 citations

Expression of β-preprotachykinin mRNA and tachykinins in rat dorsal root ganglion cells following peripheral or central axotomy

1990 • 58 citations

Comparison of substance P and enkephalin distribution in rat brain: An overview using radioimmunocytochemistry

1985 • 58 citations

Active Uptake of Substance P Carboxy‐Terminal Heptapeptide (5–11) into Rat Brain and Rabbit Spinal Cord Slices

1981 • 54 citations

Modulation of isolation-induced fighting by N- and C-terminal analogs of substance P: Evidence for multiple recognition sites

1984 • 54 citations

Cardiovascular effects of substance P peptides in the nucleus of the solitary tract

1989 • 54 citations

The role of enzymatic processing in the biological actions of substance P

1989 • 54 citations

Effects of substance P and neurokinin A (substance K) on motor behavior: unique effect of substance P attributable to its amino-terminal sequence

1987 • 53 citations

Substance P enhancement of passive and active avoidance conditioning in mice

1983 • 52 citations

Descending projections of the basal forebrain in the rat demonstrated by the anterograde neural tracer Phaseolus vulgaris leucoagglutinin (PHA-L)

1987 • 51 citations

Substance P-dopamine relationship in the rat substantia nigra: a light and electron microscopy study of double immunocytochemically labeled materials

1988 • 51 citations

Physiological Consequences of the Passage of Peptides Across the Blood-Brain Barrier

1993 • 50 citations

Enhanced inhibitory avoidance learning produced by post-trial injections of substance P into the basal forebrain

1988 • 50 citations

The Psychopharmacology of Addiction

1990 • 50 citations

Reinforcing effects of peripherally administered substance P and its C-terminal sequence pGlu6-SP6-11 in the rat

1990 • 50 citations

Substance P and neurodegenerative disorders. A speculative review

1991 • 49 citations

Facilitation of memory by peripheral administration of substance P and naloxone using avoidance and habituation learning tasks

1990 • 49 citations

Reinforcing properties of substance P in the region of the nucleus basalis magnocellularis in rats

1988 • 48 citations

Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion

1988 • 48 citations

Pharmacological characterisation of two tachykinin binding sites in the rat cerebral cortex

1985 • 48 citations

Selective agonists of tachykinin binding sites

1990 • 47 citations

GABAergic neurons in the primate basal forebrain magnocellular complex

1989 • 47 citations

Substance P injected into the region of the nucleus basalis magnocellularis facilitates performance of an inhibitory avoidance task

1986 • 46 citations

The substance P(1–7) fragment is a potent modulator of substance P actions in the brain

1990 • 46 citations

Behavioral indices of moderate nigro‐striatal 6‐hydroxydopamine lesion: A preclinical Parkinson's model

1993 • 45 citations

Modulation of memory retention by neuropeptide K

1990 • 45 citations

Pharmacological analysis of central actions of synthetic substance P.

1973 • 45 citations

Neuropeptides and their peptidases: Functional considerations

1988 • 43 citations

Facilitation of conditioned inhibitory avoidance by post-trial peripheral injection of substance P1

1986 • 42 citations

The C-terminal fragment of substance P enhances dopamine release in nucleus accumbens but not in neostriatum in freely moving rats

1992 • 41 citations

Positively reinforcing effects of the neurokinin substance P in the basal forebrain: Mediation by its C-terminal sequence

1992 • 41 citations

Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease

1989 • 41 citations

Central action of substance P: Possible role in reward

1985 • 41 citations

Neurotransmitter interactions in the basal ganglia

1988 • 41 citations

Substance P enhancement of inhibitory avoidance learning: Mediation by the N-terminal sequence

1990 • 40 citations

Correlation of substance P-induced desensitization with substance P amino terminal metabolites in the mouse spinal cord

1990 • 39 citations

Rapid degradation of [³H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

1983 • 39 citations

Substance P facilitation of memory: Effects in an appetitively motivated learning task

1986 • 39 citations

Reduced in vitro phosphorylation of synapsin I (site 1) in Alzheimer's disease postmortem tissues

1991 • 38 citations

Reinforcing properties of substance P in the lateral hypothalamus revealed by conditioned place preference

1987 • 36 citations

The substance P fragment SP(1–7) stimulates motor behavior and nigral dopamine release

1992 • 36 citations

Vasopressor effects of substance P and C-terminal sequences after intracisternal injection to α-chloralose-anaesthetized rats: Blockade by a substance P antagonist

1982 • 35 citations

Modulation of the rat mesolimbic dopamine pathway by neurokinins

1992 • 35 citations

Neuropeptide substance P improves water maze performance in aged rats

1990 • 35 citations

Substance P and Its Effects on Learning and Memory

1981 • 34 citations

Lateralized changes in behavior and striatal dopamine release following unilateral tactile stimulation of the perioral region: a microdialysis study

1991 • 32 citations

Age-dependent changes in receptor-stimulated phosphoinositide turnover in the rat hippocampus

1991 • 32 citations

Influence of substance P and fragments on passive avoidance behavior

1984 • 31 citations

Naloxone blocks conditioned place preference induced by substance P and [pGlu6]-SP(6–11)

1991 • 29 citations

Evidence for dose-dependent positively and negatively reinforcing effects of the substance P C-terminal analog DIME-C7

1990 • 28 citations

Grooming behavior induced by substance P

1988 • 28 citations

Up-hill avoidance: A new passive-avoidance task

1979 • 26 citations

Peptide hormones as prohormones: Processing, biological activity, pharmacology

1989 • 26 citations

Optimization of high-performance liquid chromatography—radioimmunoassay protocols for the analyses of substance P and some of its metabolic fragments

1988 • 26 citations

Neurobiological features common to memory modulation by many treatments

1989 • 26 citations

N- and C-terminal fragments of substance P: spinal effects in the rat tail flick test

1988 • 26 citations

Drug reward studied by the use of place conditioning in rats

1988 • 26 citations

The effect of substance P and its fragments on passive avoidance retention and brain monoamine activity

1986 • 25 citations

Locomotor activation induced in rodents by substance P and analoguesBlockade of the effect of substance P by met-enkephalin antiserum

1984 • 22 citations

Some observations indicating a low brain uptake of [3H]Nle11-Substance P.

1983 • 22 citations

Enhanced learning produced by injection of neurokinin substance P into the region of the nucleus basalis magnocellularis: Mediation by the N-terminal sequence

1992 • 20 citations

Phosphoramidon potentiates mammalian tachykinin-induced biting, licking and scratching behaviour in mice

1990 • 20 citations

Substance P modulates the release of locally synthesized nerve growth factor from rat saphenous nerve neuroma

1987 • 20 citations

Central actions of substance P and related tachykinins

1989 • 19 citations

Differential Effects of Tachykinins Injected Intranigrally on Striatal Dopamine Metabolism

1988 • 19 citations

Effect of Substance P on Vestibular Compensation

1988 • 18 citations

Mnemogenic effects of injecting RA-octil, a CE-inhibitor derivate, systemically or into the basal forebrain

1993 • 17 citations

Substance P Excites Cultured Cholinergic Neurons in the Basal Forebrain

1991 • 17 citations

Stimulatory effect of substance P on sympathetic ganglia and spinal cord in culture

1987 • 15 citations

Peripherally administered substance P affects extracellular dopamine concentrations in the neostriatum but not in the nucleus accumbens under anesthesia

1993 • 14 citations

Dual mechanism of phosphatidylinositol hydrolysis by substance P in brain

1988 • 14 citations

Nigral 5-HT and substance P-induced enhancement of passive avoidance retention

1988 • 13 citations

Substance P and neuropsychiatric disorders: An overview

1992 • 12 citations

Chapter 18 Tachykinin receptors in the CNS

1987 • 10 citations

The role of the N-terminal sequence in the biological activities of substance P.

1982 • 8 citations

Prevention of stress-induced analgesia by substance P

1983 • 7 citations

Effects of an Amino-Terminal Fragment of Substance P on Brain Dopamine and Serotonin Metabolism

1987 • 7 citations

Enhanced habituation produced by posttrial peripheral injection of substance P

1990 • 7 citations

Perspectives on Neuroscience

2007 • 6 citations

The influence of substance P and its fragments on endogenous phosphorylation of synaptosomal membrane protein (Synapsin) from cerebral cortex of rat brain

1990 • 6 citations

[Effect of derivatives of substance P dipeptide on nerve fiber growth in tissue culture].

1986 • 3 citations

Pharmacology of Basal Forebrain Involvement in Reinforcement

1991 • 3 citations

The essential sequence of substance P for locomotion.

1986 • 3 citations

Reinforcing and memory promoting effects of intracranially and peripherally applied substance P

1988 • 2 citations

Deleted Work

1955 • 0 citations