Substance P in the Nervous System

THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES

1970 • 5,141 citations

PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY

1974 • 3,882 citations

General Cytochemical Methods

1961 • 1,630 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

Fluorescent Antibody Methods

1969 • 1,549 citations

Peptidergic neurones

1980 • 1,523 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

A METHOD FOR PRODUCING SPECIFIC ANTISERA WITH SMALL DOSES OF IMMUNOGEN

1971 • 1,376 citations

Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

1977 • 1,284 citations

Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation

1979 • 1,199 citations

The Axon Reaction: A Review of the Principal Features of Perikaryal Responses to Axon Injury

1971 • 1,112 citations

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

1980 • 1,091 citations

Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons

1975 • 1,073 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

1977 • 968 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

1977 • 887 citations

Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: Immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine β-hydroxylase

1980 • 872 citations

Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla

1977 • 863 citations

Efferent connections of the habenular nuclei in the rat

1979 • 824 citations

Brainstem Control of Spinal Pain-Transmission Neurons

1978 • 820 citations

Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system

1978 • 809 citations

A new method for receptor autoradiography: [3H]Opioid receptors in rat brain

1979 • 797 citations

Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers

1979 • 785 citations

Amino-acid Sequence of Substance P

1971 • 769 citations

Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat

1976 • 758 citations

The distribution of substance P immunoreactive fibers in the rat central nervous system

1978 • 725 citations

Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

1980 • 697 citations

Isolation of a Sialogogic Peptide from Bovine Hypothalamic Tissue and Its Characterization as Substance P

1970 • 689 citations

Effects of substance P on functionally identified units in cat spinal cord

1976 • 655 citations

Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 • 642 citations

Multiple opiate receptor sites on primary afferent fibres

1980 • 621 citations

Capsaicin-induced depletion of substance P from primary sensory neurones

1978 • 596 citations

DECREASE OF SUBSTANCE P IN PRIMARY AFFERENT NEURONES AND IMPAIRMENT OF NEUROGENIC PLASMA EXTRAVASATION BY CAPSAICIN

1980 • 595 citations

Detection of substance P in the central nervous system by a monoclonal antibody.

1979 • 594 citations

Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres

1965 • 564 citations

Environmental Determination of Autonomic Neurotransmitter Functions

1978 • 550 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

Substance P as a Transmitter Candidate

1980 • 522 citations

The origin, distribution and synaptic relationships of substance P axons in rat spinal cord

1979 • 489 citations

Serotonin and substance P coexist in neurons of the rat's central nervous system

1978 • 483 citations

Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion

1980 • 471 citations

The tachykinin peptide family

1981 • 470 citations

Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

1980 • 463 citations

Flare and Itch Induced by Substance P in Human Skin

1978 • 460 citations

Substance P: Depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons

1979 • 455 citations

The monoamine innervation of rat cerebral cortex: Synaptic and nonsynaptic axon terminals

1978 • 448 citations

Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section

1975 • 443 citations

Peptide neurons in the vagus, splanchnic and sciatic nerves*

1978 • 443 citations

Regional distribution of substance P in the brain of the rat

1976 • 417 citations

Neurotransmitters decrease the calcium component of sensory neurone action potentials

1978 • 409 citations

Role of ?-aminobutyric acid (GABA) in the extrapyramidal motor system

1971 • 409 citations

Origin and distribution of glutamate decar☐ylase in substantia nigra of the cat

1974 • 396 citations

Release of Histamine from Mast Cells by Vasoactive Peptides

1973 • 389 citations

Zur Frage der zentralen �bertragung afferenter Impulse

1953 • 386 citations

A review — critical for idenctification of a central nervous system transmitter

1966 • 379 citations

Substance P release from spinal cord slices by capsaicin

1979 • 376 citations

The innervation of glomus cells, ganglion cells and blood vessels in the rat carotid body: A quantitative ultrastructural analysis

1975 • 364 citations

Effect of substance P in cat dorsal horn neurones activated by noxious stimuli

1977 • 362 citations

On the occurrence of substance P-containing fibers in sympathetic ganglia: Immunohistochemical evidence

1977 • 354 citations

Spatial and temporal transformations of input to spinothalamic tract neurons and their relation to somatic sensations

1978 • 346 citations

The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system

1978 • 337 citations

Evidence for the existence of substance P-containing fibres in striato-nigral and pallido-nigral pathways in rat brain

1977 • 334 citations

Enkephalin blocks inhibitory pathways in the vertebrate CNS

1980 • 334 citations

A peptide as a possible transmitter in sympathetic ganglia of the frog.

1979 • 329 citations

Immunocytochemical localization of substance P in mammalian intestine

1975 • 324 citations

A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain.

1977 • 322 citations

The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat

1976 • 321 citations

Medium spiny neuron projection from the rat striatum: An intracellular horseradish peroxidase study

1980 • 319 citations

Chemical Neurotoxins as Denervation Tools in Neurobiology

1980 • 318 citations

Substance P: Release on trigeminal nerve stimulation, effects in the eye

1979 • 315 citations

On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra

1977 • 314 citations

Post morten changes and regional distribution of substance P in the rat and mouse nervous system

1976 • 311 citations

Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine

1981 • 306 citations

Acetylcholinesterase hydrolyzes substance P

1980 • 306 citations

Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces Prolonged Thermal Analgesia

1979 • 303 citations

Sensory neurons in culture: Changing requirements for survival factors during embryonic development

1980 • 302 citations

Ultrastructural localization of substance P in neurons of spinal cord

1977 • 300 citations

Evidence for enkephalin immunoreactive neurons in the medulla oblongata projecting to the spinal cord

1979 • 299 citations

Regional distribution of methionine-enkephalin and substance P-like immunoreactivity in normal human brain and in Huntington's disease

1980 • 289 citations

Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat

1976 • 288 citations

Electron microscopic localization of substance P and enkephalin in axon terminals related to dendrites of catecholaminergic neurons

1979 • 287 citations

Neurotoxic action of capsaicin on spinal substance P neurons

1980 • 286 citations

Opioid Receptors Undergo Axonal Flow

1980 • 274 citations

Release of Substance P‐like Immunoreactivity from the Dental Pulp

1977 • 272 citations

Biosynthesis and axonal transport of rat neurohypophysial proteins and peptides.

1977 • 266 citations

Serotonergic and peptidergic projections to the spinal cord demonstrated by a combined retrograde HRP histochemical and immunocytochemical staining method

1981 • 266 citations

Topographic projections of substance P and GABA pathways in the striato- and pallido-nigral system: A biochemical and immunohistochemical study

1978 • 264 citations

Neurotransmitters and their receptors

1980 • 258 citations

Studies on substance P; purification, occurrence and biological actions.

1953 • 256 citations

Projections of substance P containing neurons from neostriatum to substantia nigra

1977 • 249 citations

Substance P and Excitatory Transmitter of Primary Sensory Neurons

1976 • 244 citations

Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig

1980 • 241 citations

Localization of substance P-like immunoreactivity in mouse gut

1975 • 239 citations

The electron microscopic localization of methionine-enkephalin within the superficial layers (I and II) of the spinal cord

1980 • 234 citations

The distribution of dorsal root axons in laminae I, II and III of the macaque spinal cord: A quantitative electron microscope study

1979 • 233 citations

Substance P in the substantia nigra

1976 • 232 citations

ACh, substance P and met-enkephalin in the locus coeruleus: Pharmacological evidence for independent sites of action

1979 • 230 citations

Effect of Neurotensin, Substance P and Morphine Sulfate on the Secretion of Prolactin and Growth Hormone in the Rat

1977 • 230 citations

Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro

1980 • 229 citations

Capsaicin-evoked release of substance P from primary sensory neurons

1979 • 227 citations

Substance pin spinal cord dorsal horn decreases following peripheral nerve injury

1981 • 224 citations

Radioimmunoassay for Substance P

1973 • 224 citations

Immunoreactive substance P in sympathetic ganglia: Distribution and sensitivity towards capsaicin

1981 • 221 citations

Projections of substance P-containing neurons within the guinea-pig small intestine

1981 • 217 citations

Ultrastructural identification of substance P cells and their processes in rat sensory ganglia and their terminals in the spinal cord by immunocytochemistry

1977 • 215 citations

Dual Actions of Substance P on Nociception: Possible Role of Endogenous Opioids

1978 • 212 citations

Methods in Medical Research.

1960 • 207 citations

Does substance P mediate slow synaptic excitation within the myenteric plexus?

1978 • 206 citations

Distribution of enteric neurons showing immunoreactivity for substance P in the guinea-pig ileum

1980 • 203 citations

Substance P and analgesia

1976 • 202 citations

Synthesis of Substance P

1971 • 201 citations

Degenerative changes in primary trigeminal axons and in neurons in nucleus caudalis following tooth pulp extirpations in the cat

1977 • 199 citations

Nerve growth factor stimulates the development of substance P in sensory ganglia.

1980 • 198 citations

Muscarinic, alpha‐adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland.

1977 • 197 citations

SUPPRESSION OF TRANSMISSION OF NOCICEPTIVE IMPULSES BY MORPHINE: SELECTIVE EFFECTS OF MORPHINE ADMINISTERED IN THE REGION OF THE SUBSTANTIA GELATINOSA

1977 • 195 citations

Restrictions of developmental capabilities in neural crest cell derivatives as tested by in vivo transplantation experiments

1980 • 195 citations

Substance P containing and cholinergic projections from the habenula

1978 • 194 citations

Electrophysiological analysis of reciprocal caudato-nigral relations

1967 • 194 citations

Requirement of nerve growth factor for development of substance P-containing sensory neurones

1980 • 194 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—II. Light microscopic localization in relation to catecholamine-containing neurons

1978 • 193 citations

Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides

1977 • 193 citations

VIP-, enkephalin-, substance P- and somatostatin-like immunoreactivity in neurons intrinsic to the intestine: immunohistochemical evidence from organotypic tissue cultures

1978 • 189 citations

Distribution of chemosensitive primary sensory afferents in the central nervous system of the rat

1980 • 189 citations

Morphine, enkephalin and the substantia gelatinosa

1976 • 188 citations

Substance P in the vagus nerve

1979 • 184 citations

Substance P and Spinal Neurones

1975 • 183 citations

Nerve cell degeneration and death in the trigeminal ganglion of the adult rat following peripheral nerve transection

1978 • 182 citations

Evidence for the release of endogenous substance P from intestinal nerves

1979 • 182 citations

In vitro autoradiography of opiate receptors in rat brain suggests loci of "opiatergic" pathways.

1980 • 181 citations

Distribution of [Met5]- and [Leu5]-enkephalin-, vasoactive intestinal polypeptide- and substance P-like immunoreactivities in human adrenal glands

1980 • 181 citations

The permanent anatomical effects of neonatal capsaicin on somatosensory nerves.

1980 • 180 citations

Caudate stimulation and substantia nigra activity in the rat.

1976 • 179 citations

PURIFICATION AND PROPERTIES OF A PROLYL ENDOPEPTIDASE FROM RABBIT BRAIN

1979 • 179 citations

Antagonism between Lioresal and substance P in rat spinal cord

1975 • 178 citations

Coexistence of Several Putative Neurotransmitters in Single Identified Neurosn of Aplysia

1974 • 178 citations

Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body

1980 • 174 citations

DESENSITIZATION WITH CAPSAICIN AND RELATED ACYLAMIDES AS A TOOL FOR STUDYING THE FUNCTION OF PAIN RECEPTORS

1968 • 173 citations

Substance P inhibits nicotinic activation of chromaffin cells

1979 • 170 citations

Purification and Characterisation of a Membrane-Bound Substance-P-Degrading Enzyme from Human Brain

1981 • 170 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

Localization of substance P-like immunoreactivity in nerves in the tooth pulp

1977 • 168 citations

Effects of capsaicin on nociceptive heat, pressure and chemical thresholds and on substance P levels in the rat

1980 • 167 citations

The spiny neurons in the primate striatum: a Golgi and electron microscopic study

1972 • 167 citations

The action of substance P on neurons of the myenteric plexus of the guinea-pig small intestine

1979 • 167 citations

Handbook of Psychopharmacology

1987 • 164 citations

The action of thyrotropin-releasing hormone, substance P and related peptides on frog spinal motoneurons.

1978 • 164 citations

The substantia gelatinosa Rolandi of the rat. Fine structure, cytochemistry (acid phosphatase) and changes after dorsal root section

1974 • 163 citations

Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture

1978 • 163 citations

Effect of peripheral axotomy on the fine structure and histochemistry of the Rolando substance: Degenerative atrophy of central processes of pseudounipolar cells

1976 • 163 citations

Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons

1981 • 161 citations

A modified peroxidase--antiperoxidase procedure for improved localization of tissue antigens: localization of substance P in rat spinal cord.

1980 • 161 citations

Habenulo-interpeduncular tract: a possible cholinergic neuron in rat brain

1973 • 160 citations

Presence of substance P and GABA in separate striatonigral neurons

1977 • 157 citations

Peptides in the cat carotid body (glomus caroticum): VIP‐, enkephalin‐, and substance P‐like immunoreactivity

1979 • 157 citations

Behavioral evidence that substance P may be a spinal cord sensory neurotransmitter

1981 • 156 citations

Histochemistry and Cell Biology of Autonomic Neurons, SIF Cells, and Paraneurons

1981 • 155 citations

Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs.

1965 • 155 citations

Peripheral Nerve Abnormalities in the Riley-Day Syndrome

1971 • 155 citations

Effects of substance P on neurones in the dorsal horn of the spinal cord of the cat

1979 • 155 citations

Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin

1969 • 152 citations

Effects of intranigral application of dopamine and substance P on the in vivo release of newly synthesized [3H]-dopamine in the ipsilateral caudate nucleus of the cat

1977 • 152 citations

LUTEINIZING HORMONE‐RELEASING FACTOR AND MUSCARINIC AGONISTS ACT ON THE SAME VOLTAGE‐SENSITIVE K⁺ ‐CURRENT IN BULLFROG SYMPATHETIC NEURONES

1980 • 150 citations

Regulation of substance P in adult rat sympathetic ganglia

1982 • 150 citations

Inhibition of antidromic and substance P‐induced vasodilatation by a substance P antagonist

1981 • 148 citations

Synaptic organization of the substantia gelatinosa glomeruli in the spinal trigeminal nucleus of the adult cat

1974 • 148 citations

Substance P in the vagal sensory ganglia: Localization in cell bodies and pericellular arborizations

1980 • 147 citations

Preterminal and terminal axon arborizations in the substantia gelatinosa of cat's spinal cord

1977 • 145 citations

Effects of Morphine and Naloxone on Dorsal Horn Neurones in the Cat

1974 • 143 citations

Nociceptive threshold after neonatal capsaicin treatment

1979 • 139 citations

Localisation of substance P immunoreactivity in amacrine cells of the retina

1980 • 138 citations

Studies on the Interaction of Endorphins, Substance P, and Endogenous Somatostatin in Growth Hormone and Prolactin Release in Rats*

1978 • 138 citations

Immunohistochemical studies of the enteric nervous system in tissue culture and in situ: Localization of vascoactive intestinal polypeptide (VIP), substance-P and enkephalin immunoreactive nerves in the guinea-pig gut

1980 • 138 citations

Actions of substance P on sympathetic neurons

1979 • 137 citations

Specific binding of 3H-substance P to rat brain membranes

1980 • 137 citations

Human brain substance P: distribution in controls and Huntington's chorea

1978 • 137 citations

The Nature and the Distribution of Afferent Fibres Provided with the Axon Reflex Arrangement

1953 • 137 citations

Release and metabolism of substance P in rat hypothalamus

1976 • 135 citations

Pain in the Trigeminal Region

1978 • 135 citations

Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones

1979 • 134 citations

Substance P: localization in synaptic vesicles in rat central nervous system

1977 • 133 citations

Substance P and Renshaw cells: a new concept of inhibitory synaptic interactions.

1977 • 132 citations

Approaches to the cell biology of neurons

1977 • 131 citations

Evidence for a decrease in substance P content of substantia nigra in Huntington's chorea

1977 • 130 citations

Chemical design of antagonists of substance P

1981 • 129 citations

Substance P- and enkephalin-containing neurones in the rat trigeminal system

1980 • 129 citations

Effect of Substance P on Various Vascular Beds in the Dog

1975 • 129 citations

Pharmacological characterization of adrenal paraneurons: substance P and somatostatin as inhibitory modulators of the nicotinic response

1979 • 128 citations

The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat

1976 • 127 citations

Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline cleaving enzyme from bovine brain

1980 • 127 citations

Substance P: A Polypeptide of Possible Physiological Significance, Especially Within the Nervous System

1962 • 125 citations

Peptidergic transmitters in synaptic boutons of sympathetic ganglia

1980 • 124 citations

Slow synaptic excitation mediated by serotonin in Auerbach's plexus

1978 • 119 citations

Substance P enhances cholinergic receptor desensitization in a clonal nerve cell line.

1980 • 119 citations

Transganglionic degeneration in the spinal trigeminal nucleus following removal of tooth pulps in adult cats

1976 • 119 citations

Analgesic activity of substance P following intracerebral administration in rats

1978 • 119 citations

Opiate receptors in cultures of fetal mouse dorsal root ganglia (DRG) and spinal cord: predominance in DRG neurites

1978 • 116 citations

Recovery of substance P in the cat spinal cord after unilateral lumbosacral deafferentation

1980 • 116 citations

Evidence for substance P in the striato-nigral tract

1977 • 115 citations

Further evidence for peptidergic transmission in sympathetic ganglia.

1980 • 115 citations

STIMULATORY EFFECTS OF SUBSTANCE P ON NEURITE EXTENSION AND CYCLIC AMP LEVELS IN CULTURED NEUROBLASTOMA CELLS

1978 • 115 citations

Substance P and noncholinergic excitatory synaptic transmission in guinea pig sympathetic ganglia.

1979 • 114 citations

Evidence for substance P in the habenulo-interpeduncular tract

1976 • 112 citations

Somatostatin and substance P inhibit catecholamine secretion from isolated cells of guinea-pig adrenal medulla

1981 • 111 citations

Evidence that axons containing substance P in the guinea-pig ileum are of intrinsic origin

1979 • 111 citations

Distribution of substance P-like immuno-reactivity in the rat central nervous system as revealed by immunohistochemistry.

1974 • 111 citations

<b>PEPTIDERGIC EXCITATORY AND INHIBITORY SYNAPSES IN MAMMALIAN SYMPATHETIC GANGLIA: ROLES OF SUBSTANCE P AND </b><b>ENKEPHALIN </b>

1980 • 110 citations

Capsaicin depletes CCK-like immunoreactivity detected by immunohistochemistry, but not that measured by radioimmunoassay in rat dorsal spinal cord

1982 • 109 citations

Tissue concentration and release of substance P‐like immunoreactivity in the dental pulp

1981 • 108 citations

Identification of the motoneuron-depolarizing peptide in bovine dorsal root as hypothalamic substance P

1974 • 107 citations

Stimulatory effects of substance P and nerve growth factor (NGF) on neurite outgrowth in embryonic chick dorsal root ganglia

1978 • 107 citations

THE COMPONENT OF THE DORSAL ROOT MEDIATING VASODILATATION AND THE SHERRINGTON CONTRACTURE

1930 • 106 citations

Peptide-containing neurones connect the two ganglionated plexuses of the enteric nervous system

1980 • 104 citations

Substance P: Does It Produce Analgesia or Hyperalgesia?

1980 • 104 citations

Combined immunocytochemistry and autoradiography after in vivo injections of monoclonal antibody to Substance P and 3H-serotonin:

1979 • 103 citations

Enzymes involved in the degradation of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) in bovine brain

1979 • 102 citations

Evidence that substance P is a neurotransmitter in the myenteric plexus

1980 • 102 citations

THE SUBCELLULAR DISTRIBUTIONS OF ACETYLCHOLINE, SUBSTANCE P, 5‐HYDROXYTRYPTAMINE, γ‐AMINOBUTYRIC ACID AND GLUTAMIC ACID IN BRAIN HOMOGENATES

1964 • 102 citations

Release of substance P from isolated nerve endings

1976 • 100 citations

Behavioral activation induced in the rat by substance P infusion into ventral tegmental area: Implication of dopaminergic A10 neurones

1979 • 97 citations

Evidence that TRH, somatostatin and substance P are present in neurosecretory elements of the vertebrate retina

1980 • 95 citations

Neurobiology of peptides.

1978 • 94 citations

Synapses in the interpeduncular nucleus: Electron microscopy of normal and habenula lesioned rats

1976 • 94 citations

A neuropeptide in mammalian tissues with physalaemin-like immunoreactivity

1980 • 93 citations

Distribution of histamine and substance P in the wall of the dog's digestive tract

1951 • 93 citations

EFFECTS OF SUBSTANCE P INJECTED INTO THE SUBSTANTIA NIGRA

1979 • 92 citations

Effects of habenular lesions on the substance P content of various brain regions

1976 • 91 citations

The paratrigeminal nucleus. II. Identification and inter-relations of catecholamine axons, indoleamine axons, and Substance P immunoreactive cells in the neuropil

1978 • 89 citations

Substance P release from the rat substantia nigra

1978 • 89 citations

Enzymatic inactivation of substance p by a partially purified enzyme from rat brain

1975 • 87 citations

Axonal Transport of Neuropeptides in the Cervical Vagus Nerve of the Rat

1980 • 86 citations

Effects of substance P on carotid chemoreceptor activity in the cat.

1980 • 86 citations

Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

1979 • 86 citations

Brain Peptides

1981 • 86 citations

Substance P: Evidence for Diverse Roles in Neuronal Function from Cultured Mouse Spinal Neurons

1979 • 86 citations

Isolierung und Aminosäuresequenz von Substanz P aus Pferdedarm

1973 • 86 citations

Parallel bioassay of physalaemin and kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis

1980 • 85 citations

Is the Tonic Decerebrate Inhibition of Reflex Paths Mediated by Monoaminergic Pathways?

1968 • 84 citations

Cycloheximide-sensitive synthesis of substance P by isolated dorsal root ganglia

1980 • 84 citations

Synthesis and Biological Properties of Enzyme‐Resistant Analogues of Substance P

1981 • 83 citations

Substance P: Regional distribution and specific binding to synaptic membranes in rabbit central nervous system

1978 • 82 citations

Increased dopamine metabolism in rat striatum after infusions of substance P into the substantia nigra

1978 • 82 citations

Substance P immunoreactive neurons following neonatal administration of capsaicin

1981 • 82 citations

The Effects of Substance P and Baclofen on Motoneurones of Isolated Spinal Cord of the Newborn Rat

1980 • 82 citations

Substance P and 5-HT in granules isolated from an intestinal argentaffin carcinoid

1977 • 81 citations

Effect of substance P and eledoisin on K+ efflux, amylase release and cyclic nucleotide levels in slices of rat parotid gland

1976 • 81 citations

The aspiny neurons and the glia in the primate striatum: a golgi and electron microscopic study.

1971 • 79 citations

Substance P effects on spinal nociceptive neurones

1979 • 77 citations

Rotatory behavior in rats by intranigral application of substance P and an eledoisin fragment

1977 • 77 citations

SUBCELLULAR DISTRIBUTION OF SUBSTANCE P IN BOVINE HYPOTHALAMUS AND SUBSTANTIA NIGRA

1975 • 77 citations

Enhancement in Ia-motoneuron synaptic transmission caudal to chronic spinal cord transection

1979 • 77 citations

Dense plexus of substance P immunoreactive nerve terminals in eminentia medialis of the primate hypothalamus

1978 • 76 citations

A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat

1981 • 76 citations

The development and application of a novel N-terminal directed substance P antiserum

1980 • 76 citations

Enkephalin and substance P effects related to trigeminal pain

1978 • 76 citations

Substance P: A carotid body peptide

1980 • 76 citations

Effects of the unilateral nigral modulation of substance P transmission on the activity of the two nigro-striatal dopaminergic pathways

1979 • 75 citations

Behavioural and biochemical effects of substance P injected into the substantia nigra of the rat

1977 • 75 citations

Presynaptic inhibition in Aplysia involves a decrease in the Ca2+ current of the presynaptic neuron.

1980 • 74 citations

Vasodilatation in the dental pulp produced by electrical stimulation of the inferior alveolar nerve in the cat

1980 • 74 citations

Localization of substance P immunoreactive nerves in the carotid body

1980 • 73 citations

Slowly-developing depolarization of neurones in the guinea-pig inferior mesenteric ganglion following repetitive stimulation of the preganglionic nerves

1978 • 73 citations

Responses of single units in laminae 2 and 3 of cat spinal cord

1979 • 71 citations

Substance P selectively blocks excitation of Renshaw cell by acetylcholine

1977 • 70 citations

Effects of GABA, dopamine, and substance P on the release of newly synthesized 3H-5-hydroxytryptamine from rat substantia nigra in vitro

1978 • 69 citations

Substance P in the amygdaloid complex, bed nucleus and stria terminalis of the rat brain

1978 • 69 citations

Effect of the immunoneutralization of substance P in the cat substantia nigra on the release of dopamine from dendrites and terminals of dopamine-ergic neurons

1978 • 69 citations

Control of calcium channels by membrane receptors in the rat parotid gland.

1978 • 69 citations

The effect of putative peptide neurotransmitters on cutaneous vascular permeability in the rat

1979 • 68 citations

Effect of substance P, neurotensin and the enkephalins on somatostatin release from the rat hypothalamus in vitro

1979 • 68 citations

Retrograde axonal transport of horseradish peroxidase in afferent fibers of the inferior mesenteric ganglion of the guinea pig. Identification of the cells of origin in dorsal root ganglia

1977 • 68 citations

Substance P in human cerebrospinal fluid

1980 • 67 citations

Effect of chemical environment on levels of substance P and somatostatin in cultured sensory neurones

1981 • 66 citations

The Presence of a Motoneuron-Depolarizing Peptide in Bovine Dorsal Roots of Spinal Nerves

1972 • 65 citations

Reduction of [3H]muscimol binding sites in rat dorsal spinal cord after neonatal capsaicin treatment

1980 • 65 citations

Morphological and biochemical changes in the rat interpeduncular nucleus following the transection of the habenulo-interpeduncular tract

1975 • 65 citations

SUBSTANCE P IN SUBCELLULAR PARTICLES IN PERIPHERAL NERVES

1963 • 64 citations

Effect of substance P on intestinal muscle

1978 • 63 citations

Use of monoclonal antibodies in immunocytochemistry with special reference to the central nervous system

1980 • 63 citations

Receptor control of calcium influx in parotid acinar cells.

1978 • 63 citations

Behavioural response to bilateral injections of substance P into the substantia nigra of the rat

1978 • 62 citations

Annual Research Reviews

1982 • 61 citations

Reduction of substance P levels in the ventral cervical spinal cord of the rat after intracisternal 5, 7-dihydroxytryptamine injection

1979 • 60 citations

Nerve growth factor stimulates development of substance P in the embryonic spinal cord

1981 • 60 citations

SUBSTANCE P: ITS PHARMACOLOGY AND PHYSIOLOGICAL ROLES

1977 • 59 citations

Actions of the p-chlorophenyl derivative of GABA, lioresal, on nociceptive and non-nociceptive units in the spinal cord of the cat

1976 • 59 citations

Selective neurotoxic action of capsaicin on glomerular C-type terminals in rat substantia gelatinosa

1981 • 59 citations

Biological activity and enzymic degradation of substance P analogs: Implications for studies of the substance P receptor

1979 • 58 citations

Interaction of physalaemin, substance P, and eledoisin with specific membrane receptors on pancreatic acinar cells.

1979 • 58 citations

�ber die Aktionssubstanz der sensiblen Nerven

1948 • 57 citations

Effects of neonatal administration of capsaicin on nociceptive thresholds in the mouse and rat

1981 • 57 citations

Morphine does not antagonize the substance P mediated excitation of dorsal horn neurons

1980 • 56 citations

Substance P-induced analgesia in the rat

1979 • 56 citations

Intracerebral substance P in mice: behavioral effects and narcotic agents

1981 • 53 citations

Substance P biosynthesis in dorsal root ganglia: An immunochemical study of [35S]methionine and [3H]proline incorporation in vitro

1981 • 53 citations

Calcium-dependent presynaptic action of substance P at the frog neuromuscular junction

1977 • 53 citations

Depletion of substance P‐like immunoreactivity in the cat dental pulp by antidromic nerve stimulation

1981 • 52 citations

Distinct classes of substance P receptors revealed by a comparison of the activities of substance P and some of its segments

1981 • 52 citations

Effects of substance P, acetylcholine and stimulation of habenula on rat interpeduncular neuronal activity

1978 • 51 citations

Contribution to the Theory that Substance P has a Transmitter Role in Sensitive Pathway

1964 • 50 citations

Quantitative studies of the vagus nerve in the cat. II. The ratio of jugular to nodose fibers

1937 • 50 citations

Substance P degradation by rat brain peptidases: Inhibition bY SQ 20881

1979 • 50 citations

Morphine and met-enkephalin effects of sural aδ- afferent terminal excitability

1978 • 50 citations

Enzymatic synthesis of acetylcholine by a serotonin-containing neurone from Helix

1974 • 49 citations

Identification by high-performance liquid chromatography of immunoreactive substance P released from isolated rat spinal cord

1980 • 48 citations

Angiotensin mimics the action of muscarinic agonists on rat sympathetic neurones

1980 • 48 citations

Distribution of substance P in the pigeon brain

1978 • 48 citations

Delayed iontophoretic ejection of substance P from glass micropipettes: Correlation with time-course of neuronal excitation in vivo

1979 • 47 citations

Substance P and opiate-like peptides in human adrenal medulla

1980 • 47 citations

In vivo release of substance P in the cat substantia nigra

1979 • 46 citations

Lack of algesic effect of substance P on paravascular pain receptors

1977 • 46 citations

On the origin of substance P-containing fibres in the entopeduncular nucleus and the substantia nigra of the rat

1980 • 46 citations

Inhibitory effects of GABA, L-glutamic acid and nicotine on the potassium-evoked release of subsaance P in substantia nigra slices of the rat

1981 • 45 citations

Relative numbers of several types of synaptic connections in the substantia gelatinosa of the cat spinal cord

1978 • 45 citations

An evaluation of d-α-aminoadipate and d-(and dl-)α-aminosuberate as selective antagonists of excitatory amino acids in the substantia nigra and mesencephalic reticular formation of the rat

1979 • 44 citations

Is the Tonic Decerebrate Inhibition of Reflex Paths Mediated by Monoaminergic Pathways?

1968 • 44 citations

Sub-cellular Distribution of the Substance P in the Nervous Tissues

1962 • 43 citations

The unitary activity of the substantia nigra following stimulation of the striatum in the awake monkey

1975 • 43 citations

Intranigral injection of capsaicin enhances motor activity and depletes nigral 5-hydroxytryptamine but not substance P

1981 • 43 citations

Evidence that substance P does not mediate slow synaptic excitation within the myenteric plexus

1979 • 43 citations

Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. III. Identified facilitating neurons increase Ca2+ current in sensory neurons.

1981 • 43 citations

Interactions of substance P with putative mediators of inflammation and ATP

1977 • 42 citations

Substance P selectively blocks nicotinic receptors on Renshaw cells: a possible synaptic inhibitory mechanism

1977 • 41 citations

Nociceptor stimulation and PGE release by capsaicin

1980 • 41 citations

Release of substance P‐like immunoreactivity into the antral lumen of cats

1978 • 41 citations

The effect of capsaicin on the adenylate cyclase activity of rat brain

1977 • 40 citations

5-Hydroxytryptamine-containing enterochromaffin cells: storage site of substance P.

1977 • 40 citations

Is β-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?

1976 • 39 citations

Pre- and postsynaptic action of substance P at the Mauther fiber-giant fiber synapse in the hatchetfish

1976 • 39 citations

Interaction of lontophoretically applied morphine with responses of interneurons in cat spinal cord

1976 • 39 citations

Substance P: In vitro inactivation by rat brain fractions and human plasma

1979 • 39 citations

EXPERIMENTS WITH PERFUSED FROG'S SPINAL CORD

1956 • 38 citations

Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo

1980 • 38 citations

BRONCHODILATING ACTIONS OF (±)-1-(3,4,5-TRIMETHOXY-BENZYL)-1,2,3,4-TETRAHYDR01S0QUIN0L1NE (TMI) DERIVATIVES IN ANESTHETIZED CATS

1977 • 36 citations

Electron microscope immunohistochemical localization of substance P in the central nervous system of the rat.

1977 • 36 citations

Immunocytochemical detection of Substance P neurons, their processes and connections by in vivo microinjections of monoclonal antibodies

1979 • 35 citations

Diffuse neuroendocrine system: peptides common to brain and intestine and their relationship to the APUD concept

1978 • 35 citations

Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P

1979 • 34 citations

High-sensitivity radioimmunoassay for substance P

1976 • 33 citations

Substance P, VIP, enkephalin and somatostatin immunoreactive neurons in intestinal tissue transplanted to the anterior eye chamber

1980 • 33 citations

Regional distribution of substance P within the amygdaloid complex and bed nucleus of the stria terminals

1977 • 33 citations

Separation of Two Dipeptidyl Aminopeptidases in the Human Brain

1980 • 33 citations

Screening for Rabbit Brain Neuropeptide‐metabolizing Peptidases. Inhibition of Endopeptidase B by Bradykinin Potentiating Peptide 9a (SQ 20881)

1980 • 32 citations

Nerve growth factor-mediated increase of the substance P content of chick embryo dorsal root ganglia

1979 • 32 citations

Substance P: Characteristics of binding to synaptic vesicles of rat brain

1979 • 32 citations

Modulation of cat monosynaptic reflexes by substance P

1980 • 32 citations

In vitro activities of some synthetic substance P analogs.

1979 • 32 citations

Use of substance P partial fragments to characterize substance P receptors of cat dorsal horn neurons

1980 • 31 citations

Electrophysiological evidence for the existence of excitatory fibres in the caudato-nigral pathway in the cat

1980 • 30 citations

Substance P increases membrane conductance in parotid acinar cells

1980 • 30 citations

Lack of effect by substance P at sites in the substantia gelatinosa where met-enkephalin reduces the transmission of nociceptive impulses

1979 • 29 citations

Binding of 125I‐physalaemin to rat parotid acinar cells.

1980 • 28 citations

Synthesis and Biological Activity of Analogs of Substance P, Modified for Conformational Information by D-Amino Acids.

1979 • 27 citations

Substance P causes direct depolarisation of neurones of guinea pig interpeduncular nucleus in vitro

1979 • 27 citations

A novel class of unit in the substantia gelatinosa of the spinal cat

1977 • 26 citations

The effects of microiontophoretically applied capsaicin and substance P on single neurones in the rat and cat brain

1980 • 26 citations

Substance P and somatostatin actions on spinal cord neurons in primary dissociated cell culture.

1981 • 24 citations

Breakdown of hypothalamic peptides by hypothalamic neutral endopeptidase

1979 • 23 citations

An electron microscope study of the Auerbach's plexus and determination of substance P of the colon in Hirschsprung's disease

1974 • 22 citations

Further evidence for the possible coexistence of 5-hydroxytryptamine and substance P in medullary raphe neurones of rat brain [proceedings].

1979 • 20 citations

Response of nucleus raphe magnus neurons to iontophoretically applied substance P in rats

1980 • 19 citations

Pharmacology of naturally occurring polypeptides and lipid-soluble acids

1971 • 18 citations

Substance P-like immunoreactivity in cultured spinal ganglia from chick embryos

1978 • 17 citations

The subcellular distribution of substance of P and 5-HT in brain

1962 • 15 citations

Substance P and opioid interaction on stimulated and non-stimulated guinea pig ileum

1978 • 14 citations

Acetylcholinesterase activity of primary sensory neurons and dorsal root fibers in the cat

1978 • 14 citations

Peptide and amine transmitter effect on embryonic chick sensory neurons in vitro.

1981 • 14 citations

Studies on the vesicular component of the Auerbach's plexus and the substance P content of the mouse colon in the acute phase of the experimental Trypanosoma cruzi infection

1977 • 13 citations

The Action of Substance P on Motoneurons of the Isolated Rat Spinal Cord

1979 • 13 citations

The morphogenesis of spinal ganglia from neural crest cells.

1977 • 12 citations

Purification and properties of a Substance P-inactivating enzyme from bovine brain

1968 • 12 citations

Substance P: Indirect and direct effects on parotid acinar cell membrane potential

1981 • 11 citations

REPRESENTATION of CUTANEOUS AFFERENTS BY FLUORIDE-RESISTANT ACID PHOSPHATASE (FRAP)-ACTIVE TERMINALS IN the RAT SUBSTANTIA GELATINOSA ROLANDI

1976 • 10 citations

Estimation of substance P.

1961 • 7 citations

Antagonistic action of baclofen on substance P-induced depolarization in the isolated spinal cord of the frog

1981 • 6 citations

The ribosomal synthesis and release of methionine-enkephalin and substance P by spinal cord and brain cell cultures

1980 • 5 citations

Substance P release from rat hypothalamus and spinal cord.

1980 • 4 citations

Response of neurons in the inferior mesenteric ganglion of the guinea pig to substanceP

1979 • 1 citations