Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms ¹

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor

1983 • 751 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.

1986 • 744 citations

Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

1987 • 651 citations

Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing

1984 • 563 citations

Substance P as a Transmitter Candidate

1980 • 522 citations

Molecular characterization of a functional cDNA for rat substance P receptor

1989 • 463 citations

Regional distribution of substance P in the brain of the rat

1976 • 417 citations

Substance P in the Nervous System

1983 • 370 citations

New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization

1988 • 360 citations

Molecular Characterization of a Functional cDNA Encoding the Rat Substance P Receptor

1990 • 355 citations

Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues

1989 • 329 citations

Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system

1988 • 316 citations

Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.

1988 • 281 citations

Neuropeptide K: Isolation, structure and biological activities of a novel brain tachykinin

1985 • 279 citations

Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C

1987 • 249 citations

Selective agonists for substance P and neurokinin receptors

1987 • 239 citations

Structure and gene organization of bovine neuromedin K precursor.

1986 • 230 citations

Regional distribution of substance P, neurokinin α and neurokinin β in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection

1985 • 211 citations

Localization of tachykinin binding sites (NK1, NK2, NK3 ligands) in the rat brain

1988 • 202 citations

Regional distribution of Neuropeptide K and other tachykinins (Neurokinin A, Neurokinin B and substance P) in rat central nervous system

1986 • 195 citations

A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry

1988 • 191 citations

Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons.

1986 • 161 citations

Neuropeptide‐γ: A Peptide Isolated from Rabbit Intestine that Is Derived from γ‐Preprotachykinin

1988 • 160 citations

Decrease of substance P-like immunoreactivity in the substantia nigra and pallidum of parkinsonian brains

1983 • 148 citations

Pharmacologic characterization and autoradiographic distribution of binding sites for iodinated tachykinins in the rat central nervous system

1986 • 144 citations

Behavioural effects of receptor-specific substance P agonists

1987 • 134 citations

Neonatal and Adult 6-Hydroxydopamine-Induced Lesions Differentially Alter Tachykinin and Enkephalin Gene Expression

1987 • 122 citations

Substance P receptor binding sites are expressed by glia in vivo after neuronal injury.

1989 • 120 citations

Studies on the cellular localization of spinal cord substance P receptors

1986 • 118 citations

A cDNA encoding the precursor of the rat neuropeptide, neurokinin B

1987 • 112 citations

Studies on the coexistence of substance P with other putative transmitters in the nodose and petrosal ganglia

1990 • 111 citations

Structure-activity studies of neurokinin A

1989 • 106 citations

Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide

1990 • 105 citations

Autoradiographic localization and characterization of spinal cord substance P binding sites: high densities in sensory, autonomic, phrenic, and Onuf's motor nuclei

1985 • 101 citations

Multiple tachykinins are produced and secreted upon post-translational processing of the three substance P precursor proteins, α-, β-, and γ-preprotachykinin

1989 • 100 citations

Analysis of tachykinin binding site interactions using constrained analogues of tachykinins

1988 • 92 citations

Characterization of the effects produced by neurokinins and three agonists selective for neurokinin receptor subtypes in a spinal nociceptive reflex of the rat

1988 • 92 citations

Ultrastructural characterization of substance P‐like immunoreactive neurons in the rostral ventrolateral medulla in relation to neurons containing catecholamine‐synthesizing enzymes

1988 • 80 citations

Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P-induced salivation.

1989 • 79 citations

Substance K and substance P differentially modulate mesolimbic and mesocortical systems

1985 • 77 citations

The localization and characterization of substance P and substance K in striatonigral neurons

1986 • 68 citations

Distribution of neuropeptide K-immunoreactivity in the rat central nervous system

1986 • 68 citations

Depolarizing influences regulate preprotachykinin mRNA in sympathetic neurons.

1987 • 64 citations

Solution hybridization-nuclease protection assays for sensitive detection of differentially spliced substance P- and neurokinin A-encoding messenger ribonucleic acids

1989 • 62 citations

Striatal tachykinin gene expression regulated by interaction of D-1 and D-2 dopamine receptors.

1989 • 61 citations

Capillary permeability induced by intravenous neurokinins

1989 • 58 citations

gamma-Preprotachykinin-(72-92)-peptide amide: an endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors.

1990 • 57 citations

Substance P-dopamine relationship in the rat substantia nigra: a light and electron microscopy study of double immunocytochemically labeled materials

1988 • 51 citations

Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices

1985 • 44 citations

Spinal action of neurokinins producing cardiovascular responses in the conscious freely moving rat: evidence for a NK-1 receptor mechanism

1988 • 35 citations

Heterogeneity of tachykinin-like immunoreactive peptides in rat spinal cord and dorsal root ganglia

1989 • 35 citations

Evidence that nigral substance P controls the activity of the nigrotectal GABAergic pathway

1984 • 33 citations

The Electrophysiological and Biochemical Pharmacology of the Mesolimbic and Mesocortical Dopamine Neurons

1987 • 24 citations

Evidence for Dual Mechanisms Involved in Methamphetamine-induced Increases in Striatal Preprotachykinin mRNA

1989 • 23 citations

Neurokinin B and substance P genes are co-expressed in a subset of neurons in the rat habenula

1989 • 23 citations

Subchronic haloperidol treatment decreases the in vivo release of tachykinins in rat substantia nigra

1989 • 17 citations