Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Molecular mechanisms of drug addiction

2004 • 1,080 citations

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

1988 • 996 citations

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

1992 • 962 citations

Nitric oxide (NO) and nociceptive processing in the spinal cord

1993 • 958 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

Physiological properties of unmyelinated fiber projection to the spinal cord

1966 • 836 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

1980 • 697 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission

1991 • 615 citations

Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury

1991 • 599 citations

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

1990 • 574 citations

Myelinated afferents signal the hyperalgesia associated with nerve injury

1988 • 565 citations

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 • 564 citations

Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat

1986 • 561 citations

Pharmacological Mechanisms of Opioid Analgesics

1993 • 559 citations

Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin

1987 • 545 citations

Role of NO Production in NMDA Receptor-Mediated Neurotransmitter Release in Cerebral Cortex

1994 • 476 citations

The role of nitric oxide in hippocampal long-term potentiation

1992 • 470 citations

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

1994 • 457 citations

Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid

1991 • 448 citations

1-(5-isoquinol inesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase c in rabbit platelets

1984 • 437 citations

Glutamate receptor channels: novel properties and new clones

1992 • 427 citations

The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation

1992 • 422 citations

Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat

1992 • 419 citations

Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

1993 • 400 citations

Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms

1989 • 395 citations

Molecular mechanisms of drug addiction [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

1992 • 392 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli

1992 • 370 citations

The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man

1994 • 368 citations

Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine

1990 • 356 citations

Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons

1990 • 355 citations

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1992 • 354 citations

A Spatial-Temporal Model of Cell Activation

1988 • 347 citations

Spatial and temporal transformations of input to spinothalamic tract neurons and their relation to somatic sensations

1978 • 346 citations

Trigeminothalamic neurons in nucleus caudalis responsive to tactile, thermal, and nociceptive stimulation of monkey's face

1976 • 343 citations

Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons

1990 • 341 citations

Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain

1995 • 330 citations

A cure for wind up: NMDA receptor antagonists as potential analgesics

1990 • 327 citations

Functional Modulation of Brain Sodium Channels by Protein Kinase C Phosphorylation

1991 • 325 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

The role of protein kinase C in the regulation of ion channels and neurotransmitter release

1987 • 310 citations

Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.

1987 • 309 citations

Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists

1992 • 301 citations

Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat

1991 • 298 citations

Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

1992 • 286 citations

Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

1993 • 282 citations

The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids

1994 • 279 citations

MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy

1991 • 276 citations

Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn

1986 • 273 citations

Imaging of Memory-Specific Changes in the Distribution of Protein Kinase C in the Hippocampus

1989 • 271 citations

Heterogeneous localization of protein kinase C in rat brain: autoradiographic analysis of phorbol ester receptor binding

1986 • 267 citations

An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy

1993 • 266 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

High Doses of Spinal Morphine Produce a Nonopiate Receptormediated Hyperesthesia

1986 • 256 citations

A Phosphorylation Site in the Na ⁺ Channel Required for Modulation by Protein Kinase C

1991 • 252 citations

Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block

1989 • 249 citations

Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy

1993 • 246 citations

The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats

1992 • 242 citations

Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge

1991 • 236 citations

Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy

1992 • 236 citations

Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.

1993 • 214 citations

The development of morphine tolerance and dependence is associated with translocation of protein kinase C

1995 • 212 citations

Morphine differentially affects the sensory and affective pain ratings in neurogenic and idiopathic forms of pain

1991 • 209 citations

Sensory testing of pathophysiological mechanisms of pain in patients with reflex sympathetic dystrophy

1992 • 208 citations

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

1992 • 202 citations

The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn

1992 • 200 citations

Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy

1992 • 197 citations

Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.

1988 • 194 citations

The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury

1992 • 190 citations

Contribution of protein kinase C to central sensitization and persistent pain following tissue injury

1992 • 182 citations

Hyperalgesia during Naloxone-Precipitated Withdrawal from Morphine Is Associated with Increased On-Cell Activity in the Rostral Ventromedial Medulla

1990 • 181 citations

Differential regulation by cAMP-dependent protein kinase and protein kinase C of the mu opioid receptor coupling to a G protein-activated K+ channel.

1994 • 163 citations

Neuronal responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy

1990 • 156 citations

The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat

1992 • 155 citations

Multiple effects of phorbol esters in the rat spinal dorsal horn

1989 • 153 citations

Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord

1994 • 152 citations

Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat

1993 • 151 citations

Central neural mediators of secondary hyperalgesia following heat injury in rats: Neuropeptides and excitatory amino acids

1991 • 151 citations

Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury

1992 • 150 citations

Spinal Afferent Processing

1986 • 149 citations

Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy

1993 • 146 citations

Spinal Afferent Processing

1987 • 145 citations

Idiopathic trigeminal neuralgia: sensory features and pain mechanisms

1987 • 139 citations

Delayed application of MK-801 attenuates development of morphine tolerance in rats

1991 • 138 citations

Increases in protein kinase C gamma immunoreactivity in the spinal cord of rats associated with tolerance to the analgesic effects of morphine

1995 • 137 citations

Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord.

1992 • 135 citations

Characterization of a Presynaptic Glutamate Receptor

1993 • 132 citations

Do NMDA receptors have a critical function in visual cortical plasticity?

1993 • 131 citations

Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions

1992 • 129 citations

NMDA evokes an l-NAME sensitive spinal release of glutamate and citrulline

1993 • 127 citations

Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs

1991 • 116 citations

The non-NMDA receptors: types, protein structure and molecular biology

1990 • 115 citations

Neurochemical and Anatomical Changes in the Dorsal Horn of Rats with an Experimental Painful Peripheral Neuropathy

1989 • 114 citations

The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction

1989 • 111 citations

Spatial patterns of spinal cord [14C]-2-deoxyglucose metabolic activity in a rat model of painful peripheral mononeuropathy

1992 • 110 citations

Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors

1993 • 109 citations

Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy

1993 • 108 citations

MK-801 inhibits the development of morphine tolerance at spinal sites

1993 • 98 citations

Is disease progression the major factor in morphine ‘tolerance’ in cancer pain treatment?

1993 • 96 citations

Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801

1993 • 94 citations

Neurobiological Mechanisms of Opioid Tolerance and Dependence

1991 • 84 citations

Opiate tolerance and dependence: recent findings and synthesis.

1991 • 82 citations

Strychnine-enhanced transsynaptic degeneration of dorsal horn neurons in rats with an experimental painful peripheral neuropathy

1989 • 74 citations

Painful sequelae of nerve injury

1987 • 68 citations

Invited review: Role of receptor regulation in opioid tolerance mechanisms

1988 • 67 citations

The effect of phorbol esters on the responses of primate spinothalamic neurons to mechanical and thermal stimuli

1994 • 62 citations

Gangliosides: the relevance of current research to neurosurgery

1991 • 54 citations

Dissociation of mu opioid tolerance from receptor down-regulation in rat spinal cord.

1990 • 48 citations

A call for more science, not more rhetoric, regarding opioids and neuropathic pain

1991 • 48 citations

Pretreatment with gangliosides reduces abnormal nociceptive responses associated with a rodent peripheral mononeuropathy

1992 • 48 citations

Intrathecal GM1 ganglioside and local nerve anesthesia reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

1992 • 46 citations

Inhibition of nitric oxide synthase protects against hypoxic neuronal injury

1992 • 45 citations

Regional changes in spinal cord glucose metabolism in a rat model of painful neuropathy

1991 • 44 citations

Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy

1992 • 44 citations

Deafferentation Pain Syndromes

1989 • 44 citations

Phosphorylated μ-opioid receptor purified from rat brains lacks functional coupling with Gi1, a GTP-binding protein in reconstituted lipid vesicles

1990 • 43 citations

The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during autotomy after sciatic nerve section in rats

1991 • 43 citations

Gangliosides Prevent Ischemia‐Induced Down‐Regulation of Protein Kinase C in Fetal Rat Brain

1990 • 37 citations

The molecular biology of addictive drugs

1991 • 36 citations

Effect of protein kinase C modulation on outcome of experimental CNS ischemia

1991 • 36 citations

Intracerebroventricular treatment of mice with pertussis toxin induces hyperalgesia and enhances 3H-nitrendipine binding to synaptic membranes: Similarity with morphine tolerance

1990 • 32 citations

Spinal mediators of nociceptive neurotransmission and hyperalgesia

1993 • 26 citations

The Effects of Intrathecally Administered Opioid and Adrenergic Agents on Spinal Function

1986 • 22 citations

Amniotic-fluid ingestion enhances morphine analgesia during morphine tolerance and withdrawal in rats

1991 • 14 citations

Conditioned tolerance to morphine hypoalgesia: compensatory hyperalgesia in the experimental group or conditioned hypoalgesia in the control group?

1992 • 13 citations

Chronic morphine administration and in vivo pertussis toxin treatment induce hyperalgesia and enhance 3H-nitrendipine binding.

1990 • 12 citations

Pain management: physiopathology, future research and endpoints

1993 • 11 citations

Deleted Work

1955 • 0 citations

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