The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Evidence for a central component of post-injury pain hypersensitivity

1983 • 2,103 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Agonists and antagonists for excitatory amino acid receptors

1987 • 692 citations

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

1989 • 671 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Amino acid neurotransmitters and their pathways in the mammalian central nervous system

1983 • 646 citations

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord.

1988 • 580 citations

Pain Sensations and Reactions

1953 • 553 citations

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia

1991 • 453 citations

Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid

1991 • 448 citations

Somatosensory system

1973 • 443 citations

Determination of Brain Interstitial Concentrations by Microdialysis

1989 • 410 citations

Extracellular Amino Acid Concentrations in the Dorsal Spinal Cord of Freely Moving Rats Following Veratridine and Nociceptive Stimulation

1988 • 396 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

1988 • 363 citations

Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli

1968 • 335 citations

Neurotransmitter candidates of somatosensory primary afferent fibres

1983 • 331 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

Inhibitory transmission in the basolateral amygdala

1991 • 284 citations

Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of n-methyl-d-aspartic acid and substance P

1991 • 281 citations

Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord

1990 • 259 citations

The antagonism of amino acid-induced excitation of spinal neurones in the cat

1979 • 259 citations

Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord

1983 • 243 citations

The effects of dorsal rhizotomy and spinal cord isolation on calcitonin gene-related peptide-labeled terminals in the rat lumbar dorsal horn

1988 • 224 citations

Effects of iontophoretically released amino acids and amines on primate spinothalamic tract cells

1984 • 213 citations

Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate

1985 • 175 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

Substance P modulates glutamate-induced currents in acutely isolated rat spinal dorsal horn neurones

1990 • 165 citations

Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids

1992 • 161 citations

Excitatory transmission in the basolateral amygdala

1991 • 160 citations

Neural changes in acute arthritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn

1992 • 154 citations

Spinal cord potentials evoked by cutaneous afferents in the monkey

1977 • 151 citations

Long-term changes in discharge behaviour of cat dorsal horn neurones following noxious stimulation of deep tissues

1989 • 144 citations

Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

1989 • 139 citations

S-glutamate: Its interactions with spinal neurons

1981 • 137 citations

Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by μ-opioids

1991 • 135 citations

IntrathecalN-methyl-d-aspartate (NMDA) activates both nociceptive and antinociceptive systems

1987 • 130 citations

Selective excitation of neurons in the mammalian spinal dorsal horn by aspartate and glutamate in vitro: correlation with location and excitatory input

1985 • 116 citations

Glutamate-like immunoreactive structures in primary sensory neurons in the rat detected by a specific antiserum against glutamate

1987 • 108 citations

Effects of iontophoretically released peptides on primate spinothalamic tract cells

1984 • 93 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, And Distinct Properties In The Function Of The Central Nervous System

1989 • 90 citations

Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-d-aspartate antagonist

1991 • 84 citations

Excitatory amino acid-mediated components of synaptically evoked input from dorsal roots to deep dorsal horn neurons in the rat spinal cord slice

1989 • 84 citations

Participation of excitatory amino acid receptors in the slow excitatory synaptic transmission in the rat spinal dorsal horn in vitro

1989 • 82 citations

An instrument using a multiple layer peltier device to change skin temperature rapidly

1984 • 82 citations

An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice

1988 • 74 citations

Antagonists of synaptic and amino acid excitation of neurones in the cat spinal cord

1983 • 69 citations

First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

1986 • 69 citations

Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells

1990 • 62 citations

Responses of primate spinothalamic tract neurons to electrical stimulation of hindlimb peripheral nerves

1975 • 59 citations

Distribution of glutamic acid, aspartic acid, γ-aminobutyric acid and glycine in six areas of cat spinal cord before and after transection

1968 • 56 citations

Primary afferent depolarization in the rat spinal cord is mediated by pathways utilising NMDA and non-NMDA receptors

1989 • 55 citations

The pharmacological selectivity of three NMDA antagonists

1988 • 53 citations

Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli

1983 • 51 citations

Static and dynamic responses of spinothalamic tract neurons to mechanical stimuli

1975 • 51 citations

Long-lasting neuronal activity in rat dorsal horn evoked by impulses in cutaneous C fibres during noxious mechanical stimulation

1988 • 44 citations

Aspartate immunoreactive axons in normal rat L4 dorsal roots

1989 • 44 citations

Responses of spinal dorsal horn neurones evoked by myelinated primary afferent stimulation are blocked by excitatory amino acid antagonists acting at kainate/quisqualate receptors

1989 • 36 citations

Patterns of spontaneous discharge in primate spinothalamic neurons

1989 • 14 citations