A cure for wind up: NMDA receptor antagonists as potential analgesics

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists

1990 • 905 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Physiological properties of unmyelinated fiber projection to the spinal cord

1966 • 836 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Phantom limb pain in amputees during the first 12 months following limb amputation, after preoperative lumbar epidural blockade

1988 • 570 citations

Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin

1987 • 545 citations

Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches

1990 • 397 citations

Excitatory amino acids and synaptic transmission: the evidence for a physiological function

1990 • 370 citations

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

1988 • 363 citations

Noncompetitive excitatory amino acid receptor antagonists

1990 • 361 citations

Postoperative orthopaedic pain — the effect of opiate premedication and local anaesthetic blocks

1988 • 316 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

The role of N‐methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli.

1987 • 104 citations

Implications of nervous system plasticity for pain management

1990 • 98 citations

A novel interaction between dynorphin(1–13) and an N-methyl-d-aspartate site

1988 • 96 citations

Central mechanisms of acute pain

1990 • 93 citations

Strychnine-enhanced transsynaptic degeneration of dorsal horn neurons in rats with an experimental painful peripheral neuropathy

1989 • 74 citations

Selective uptake of [3H]glutamine and [3H]glutamate into neurons and satellite cells of dorsal root ganglia in vitro

1983 • 61 citations

The pharmacology of segmental transmission in the spinal cord

1989 • 57 citations

The NMDA antagonist MK801 reduces noxious stimulus-evoked fos expression in the spinal dorsal horn

1990 • 20 citations

Neuronal plasticity and pain

1990 • 5 citations