Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation

1991 • 1,136 citations

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

1991 • 1,016 citations

Physiological properties of unmyelinated fiber projection to the spinal cord

1966 • 836 citations

Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices

1990 • 803 citations

Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition

1992 • 725 citations

Presynaptic mechanism for long-term potentiation in the hippocampus

1990 • 691 citations

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

1989 • 671 citations

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

1992 • 651 citations

Possible involvement of nitric oxide in long-term potentiation

1991 • 637 citations

Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission

1991 • 615 citations

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 • 564 citations

Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin

1987 • 545 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

<scp>l</scp>‐N^G‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse

1991 • 481 citations

The role of nitric oxide in hippocampal long-term potentiation

1992 • 470 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

Extracellular Amino Acid Concentrations in the Dorsal Spinal Cord of Freely Moving Rats Following Veratridine and Nociceptive Stimulation

1988 • 396 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Release of substance P from the cat spinal cord.

1987 • 371 citations

The antagonism of amino acid‐induced excitations of rat hippocampal CA1 neurones in vitro.

1983 • 360 citations

Comparison of the Antinociceptive Effects of Pre- and Posttreatment with Intrathecal Morphine and MK801, an NMDA Antagonist, on the Formalin Test in the Rat

1992 • 354 citations

The rat paw formalin test: comparison of noxious agents

1990 • 351 citations

Localization of NADPH‐diaphorase‐containing neurons in sensory ganglia of the rat

1991 • 330 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

Postoperative orthopaedic pain — the effect of opiate premedication and local anaesthetic blocks

1988 • 316 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat

1992 • 298 citations

Correlation between long‐term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats.

1986 • 289 citations

Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex

1992 • 281 citations

Pharmacology of the Spinal Action of Ketorolac, Morphine, ST-91, U50488H, and L-PIA on the Formalin Test and an Isobolographic Analysis of the NSAID Interaction

1993 • 279 citations

Distribution of reduced‐nicotinamide‐adenine‐dinucleotide‐phosphate diaphorase‐positive cells and fibers in the cat central nervous system

1989 • 278 citations

Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord

1983 • 243 citations

Kinetic characteristics of nitric oxide synthase from rat brain

1990 • 210 citations

Nadph diaphorase-positive neurons in the rat spinal cord include a subpopulation of autonomic preganglionic neurons

1992 • 204 citations

Nitric oxide may act as a messenger between dorsal root ganglion neurones and their satellite cells

1992 • 136 citations

Clinical Uses of Intravenous Anesthetic and Analgesic Infusions

1989 • 93 citations

Analgesic Effect of Intrathecal Ketamine in the Rat

1981 • 32 citations