The role of protein kinase C in the regulation of ion channels and neurotransmitter release

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Potentiation of synaptic transmission in the hippocampus by phorbol esters

1986 • 647 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C

1985 • 476 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Protein phosphorylation in the nervous system

1984 • 329 citations

Protein kinase C activation induces conductance changes in Hermissenda photoreceptors like those seen in associative learning

1986 • 289 citations

The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cells

1983 • 269 citations

Neuromodulation : the biochemical control of neuronal excitability

1987 • 237 citations

Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells

1986 • 233 citations

Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons

1986 • 219 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

Protein phosphorylation in the nervous system.

1985 • 177 citations

Aldosterone secretion: Effect of phorbol ester and A23187

1983 • 175 citations

Selective increase in phosphorylation of a 47-kDa protein (F1) directly related to long-term potentiation

1985 • 152 citations

Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes.

1985 • 140 citations

Phorbol ester and calcium act synergistically to enhance neurotransmitter release by brain neurons in culture

1985 • 123 citations

Phosphorylation of the? subunit of the sodium channel by protein kinase C

1984 • 111 citations

C-Kinase activation prolongs Ca2+-dependent inactivation of K+ currents

1986 • 102 citations

Neuromodulation: The biochemical control of neuronal excitability

1987 • 84 citations

Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cells

1986 • 84 citations

Phorbol Ester Receptors: Autoradiographic Identification in the Developing Rat

1983 • 78 citations

A protein kinase C inhibitory activity is present in rat brain homogenate

1984 • 70 citations

Stimulation of spontaneous transmitter release by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C

1985 • 64 citations

Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous system

1985 • 60 citations

Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction

1986 • 50 citations

Coordinated EXOSAT and spectroscopic observations of flare stars and coronal heating

2008 • 48 citations

Inhibition of the Ca2+-and phospholipid-dependent protein kinase by a novel Mr 17,000 Ca2+-binding protein

1985 • 41 citations

Diacylglycerol and phorbol esters enhance LHRH and prostaglandin E2 secretion from median eminence nerve terminals in vitro

1985 • 23 citations

[6] Synthesis and use of diacylglycerols as activators of protein kinase C in neuroendocrine tissue

1986 • 6 citations