The Effect of the scid Mutation on Mechanism and Control of Immunoglobulin Heavy and Light Chain Gene Rearrangement

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Differential expression of myc family genes during murine development

1986 • 542 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Evidence of functional lymphocytes in some (leaky) scid mice.

1988 • 347 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

1984 • 229 citations

Transcription of the unrearranged mouse Cκ locus: Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene

1981 • 190 citations

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

1987 • 187 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

1988 • 174 citations

Regulated progression of a cultured pre-B-cell line to the B-cell stage

1985 • 174 citations

Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes

1984 • 157 citations

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

1989 • 128 citations

The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.

1988 • 96 citations

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.

1988 • 94 citations

Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis.

1985 • 79 citations

Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells.

1988 • 65 citations

Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice.

1988 • 55 citations

Detection and characterization of functional T cells in mice with severe combined immune deficiency

1988 • 52 citations

Transcription of unrearranged antigen receptor genes in scid mice.

1988 • 42 citations

T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line

1989 • 37 citations

Early B-cell precursors in scid mice: Normal numbers of cells transformable with abelson murine leukemia virus (A-MuLV)

1988 • 35 citations