Antibody Repertoires of Normal BALB/c Mice: B Lymphocyte Populations Defined by State of Activation

Towards a network theory of the immune system.

1974 • 3,379 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Idiotypic Networks and Other Preconceived Ideas

1984 • 543 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

High frequency of natural autoantibodies in normal newborn mice.

1985 • 387 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1985 • 338 citations

Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens.

1983 • 303 citations

Structure, Sequence and Polymorphism in the HLA‐D Region

1985 • 302 citations

Reactions among IgM antibodies derived from normal, neonatal mice

1984 • 231 citations

Isotypes and specificities of immunoglobulins produced by germ‐free mice fed chemically defined ultrafiltered “antigen‐free” diet

1984 • 194 citations

Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice.

1983 • 188 citations

Autonomous activation of B and T cells in antigen-free mice

1986 • 184 citations

Lymphocyte Population Kinetics in the Mouse

1986 • 182 citations

Naturally occurring antibodies against nine common antigens in humans sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies.

1982 • 177 citations

Inhibition of mitogenic stimulation of mouse lymphocytes by anti‐mouse immunoglobulin antibodies. I. Mode of action

1974 • 165 citations

From an Antigen‐Centered, Clonal Perspective of Immune Responses to an Organism‐Centered, Network Perspective of Autonomous Activity in a Self‐Referential Immune System

1984 • 143 citations

Natural antibodies against tubulin, actin, myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities

1981 • 142 citations

Migration of bone marrow lymphocytes demonstrated by selective bone marrow labeling with thymidine‐H³

1970 • 126 citations

Myelogenous production and maturation of B lymphocytes in the mouse.

1981 • 126 citations

Frequencies of mitogen-reactive B cells in the mouse. II. Frequencies of B cells producing antibodies which lyse sheep or horse erythrocytes, and trinitrophenylated or nitrodophenylated sheep erythrocytes

1977 • 125 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

The high idiotypic connectivity of “natural” newborn antibodies is not found in adult mitogen‐reactive B cell repertoires

1986 • 119 citations

Self and non-sense: An organism-centered approach to immunology

1978 • 107 citations

Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice.

1986 • 97 citations

High connectivity, natural antibodies preferentially use 7183 and QUPC52 V_H families

1987 • 88 citations

Natural antibodies and autoimmunity

1985 • 79 citations

Natural effector T lymphocytes in normal mice.

1985 • 70 citations

The self-nonself discrimination and the nature and acquisition of the antibody repertoire.

1980 • 64 citations

Very rapid decay of mature B lymphocytes in the spleen.

1981 • 62 citations

Frequencies of background immunoglobulin-secreting cells in mice as a function of organ, age, and immune status

1981 • 59 citations

Immunoglobulin‐bearing stem cells for clones of B (bursa‐derived) lymphocytes

1985 • 57 citations

IgM RNA switch from membrane to secretory form is prevented by adding antireceptor antibody to bacterial lipopolysaccharide-stimulated murine primary B-cell cultures.

1985 • 55 citations

Suppression of a "recurrent" idiotype results in profound alterations of the whole B-cell compartment.

1981 • 53 citations

The polyclonal expression of immunoglobulin variable region determinants on the membrane of B cells and their precursors

1980 • 35 citations

The Uniqueness and Boundaries of the Idiotypic Self

1984 • 32 citations

Expression of V-region-like determinants on Ig-negative precursors in murine fetal liver and bone marrow

1979 • 28 citations

Idiotypic determinants of natural IgM antibodies that resemble self Ia antigens.

1984 • 28 citations

Analysis of autoantibody reactivities in hybridoma collections derived from normal adult BALB/c mice.

1986 • 25 citations

Quantitative Evidence Against Inactivation of Self‐Reactive B‐Cell Clones

1986 • 18 citations

Is the Network Theory Tautologic?

1983 • 13 citations

Frequencies of phosphorylcholine‐specific and T15‐associated 10/13 idiotope‐positive B cells within lipopolysaccharide‐reactive B cells of adult BALB/c mice

1984 • 12 citations

Comments by M. Cohn, on the Forum «Is the immune system a functional idiotypic network?

1986 • 9 citations