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Intestinal permeability and its relevance for absorption and elimination

Data up to Jan 2025

Published2007
Citations270
References194

Total Citations Per Year

Abstract

References (194)

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

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Untitled

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2007 • 158 citations

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St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism*1

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Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.

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Transport Characteristics of Fexofenadine in the Caco-2 Cell Model

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2000 • 109 citations

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Human jejunal permeability of cyclosporin A: influence of surfactants on P-glycoprotein efflux in Caco-2 cells.

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Discussion

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The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique

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Increased??Absorption??of??Digoxin from??the??Human??Jejunum Due??to??Inhibition??of??Intestinal Transporter-Mediated Efflux

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Repeated oral rifampicin decreases the jejunal permeability of R/S-verapamil in rats.

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Stereoselective Inhibition by the Diastereomers Quinidine and Quinine of Uptake of Cardiac Glycosides into Isolated Rat Hepatocytes

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The stereoisomers quinine and quinidine exhibit a marked stereoselectivity in the inhibition of hepatobiliary transport of cardiac glycosides

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