Membrane Transport of Drugs in Different Regions of the Intestinal Tract of the Rat

Nonparametric Statistical Methods

1999 • 6,387 citations

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

Nonparametric Statistical Methods.

1974 • 2,964 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals

1995 • 1,370 citations

Transport and Diffusion Across Cell Membranes

1986 • 1,042 citations

Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat

1987 • 525 citations

Mass transport Phenomena and Models: Theoretical Concepts

1974 • 516 citations

Comparison between permeability coefficients in rat and human jejunum.

1996 • 421 citations

Correlation of Drug Absorption with Molecular Surface Properties

1996 • 408 citations

Carrier-mediated intestinal transport of drugs.

1996 • 394 citations

The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons.

1995 • 366 citations

Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments.

1993 • 306 citations

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

1988 • 290 citations

Comparison between active and passive drug transport in human intestinal epithelial (caco-2) cells in vitro and human jejunum in vivo

1996 • 259 citations

Measurements of Intestinal Permeability Using Low Molecular Weight Polyethylene Glycols (PEG 400)

1977 • 243 citations

Regional rectal perfusion: a new in vivo approach to study rectal drug absorption in man.

1995 • 225 citations

Estimation of Caco‐2 Cell Permeability using Calculated Molecular Descriptors

1996 • 200 citations

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans.

1995 • 190 citations

Jejunal permeability: a comparison between the ussing chamber technique and the single-pass perfusion in humans.

1997 • 169 citations

High lipophilicity decreases drug transport across intestinal epithelial cells.

1994 • 147 citations

Variations in dietary triacylglycerol saturation alter the lipid composition and fluidity of rat intestinal plasma membranes

1985 • 137 citations

Dietary fat selectively alters transport properties of rat jejunum.

1986 • 122 citations

The relationship between peptide structure and transport across epithelial cell monolayers

1992 • 117 citations

pH-Dependent and Carrier-mediated Transport of Salicylic Acid Across Caco-2 Cells

1994 • 111 citations

Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

1985 • 91 citations

Evidence for the existence of a countercurrent exchanger in the small intestine in man

1978 • 83 citations

Surface area of the small intestine in man.

1967 • 81 citations

Mechanisms and sites of mannitol permeability of small and large intestine in the rat

1994 • 77 citations

In Vitro Absorption Studies and Their Relevance to Absorption from the GI Tract

1997 • 76 citations

Jejunal permeability and hepatic extraction of fluvastatin in humans

1996 • 75 citations

Paracellular intestinal transport of six-carbon sugars is negligible in the rat

1995 • 60 citations

Permeability characteristics of various intestinal regions of rabbit, dog, and monkey.

1992 • 58 citations

Dietary triacylglycerol modulates sodium-dependent d-glucose transport, fluidity and fatty acid composition of rat small intestinal brush-border membrane

1989 • 54 citations

Modulation of cellular phospholipid fatty acids and leukotriene B4 synthesis in the human intestinal cell (CaCo-2).

1992 • 53 citations

Determinants of apical membrane permeabilities of barrier epithelia

1994 • 49 citations

Effects of Enzymatic Inhibition and Increased Paracellular Shunting on Transport of Vasopressin Analogues in the Rat

1992 • 48 citations

Mechanism of colonic permeation of inulin: Is rat colon more permeable than small intestine?

1995 • 42 citations

The effects of bile salts and lipids on the physicochemical behavior of gemfibrozil.

1994 • 37 citations

Evidence for site-specific absorption of a novel ACE inhibitor.

1989 • 36 citations

Segmental Differences in Drug Permeability, Esterase Activity and Ketone Reductase Activity in the Albino Rabbit Intestine

1993 • 29 citations

Lipid permeability of the intestinal microvillus membrane may be modulated by membrane fluidity in the rat

1989 • 28 citations

Role of villous surface area in absorption science versus religion

1993 • 28 citations

Application of Percolation Theory to Characterize the Release Behavior of Carteolol Matrix Systems

1997 • 15 citations

Different Properties of the Paracellular Pathway Account for the Regional Small Intestinal Permeability to the Peptide Desmopressin

1995 • 15 citations

The effect of E. coli STa enterotoxin on the absorption of weakly dissociable drugs from rat proximal jejunum in vivo

1990 • 15 citations

Absorption of polar drugs following caecal instillation in healthy volunteers

1992 • 14 citations