Jejunal absorption and metabolism of R/S-verapamil in humans.

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

1997 • 620 citations

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

1996 • 598 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

Comparison between permeability coefficients in rat and human jejunum.

1996 • 421 citations

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

1995 • 342 citations

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

1996 • 280 citations

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.

1996 • 266 citations

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

1997 • 240 citations

Regional rectal perfusion: a new in vivo approach to study rectal drug absorption in man.

1995 • 225 citations

Human Jejunal Effective Permeability and Its Correlation with Preclinical Drug Absorption Models

1997 • 209 citations

Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals

1993 • 171 citations

Direct demonstration of small intestinal secretion and site-dependent absorption of the β-blocker talinolol in humans*

1996 • 128 citations

A new technique for segmental jejunal perfusion in man.

1989 • 118 citations

The effect of L‐leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.

1993 • 112 citations

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.

1996 • 112 citations

Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat.

1994 • 97 citations

Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects.

1992 • 90 citations

Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines

1991 • 72 citations

The Absence of Stereoselective P-Glycoprotein-mediated Transport of R/S-Verapamil Across the Rat Jejunum

1998 • 54 citations

Pharmacokinetics of felodipine in patients with liver disease

1989 • 53 citations

The Lack of Effect of Induced Net Fluid Absorption on thein vivoPermeability of Terbutaline in the Human Jejunum

1995 • 46 citations

A Residence-Time Distribution Analysis of the Hydrodynamics within the Intestine in Man during a Regional Single-pass Perfusion with Loc-I-Gut: In-vivo Permeability Estimation

1997 • 43 citations