Pharmacokinetics of gefitinib in humans: The influence of gastrointestinal factors

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

Characterization of fluids from the stomach and proximal jejunum in men and women.

1997 • 394 citations

Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory Region

1999 • 302 citations

Regional rectal perfusion: a new in vivo approach to study rectal drug absorption in man.

1995 • 225 citations

ABSORPTION/METABOLISM OF SULFORAPHANE AND QUERCETIN, AND REGULATION OF PHASE II ENZYMES, IN HUMAN JEJUNUM IN VIVO

2003 • 217 citations

The role of γ-scintigraphy in oral drug delivery

2001 • 205 citations

Untitled

1992 • 173 citations

The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids

1990 • 159 citations

Effect of gastrointestinal intubation on the passage of a solid meal through the stomach and small intestine in humans

1983 • 156 citations

Single-Dose Clinical Pharmacokinetic Studies of Gefitinib

2005 • 137 citations

Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man

2004 • 130 citations

Genetics of the Variable Expression of CYP3A in Humans

2004 • 118 citations

A new technique for segmental jejunal perfusion in man.

1989 • 118 citations

Pharmacokinetics and Tolerability of the Orally Active Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Healthy Volunteers

2001 • 118 citations

Gastric Emptying: Comparison of Scintigraphic, Polyethylene Glycol Dilution, and Paracetamol Tracer Assessment Techniques

2000 • 109 citations

Jejunal absorption and metabolism of R/S-verapamil in humans.

1998 • 99 citations

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine,

2003 • 88 citations

Jejunal permeability and hepatic extraction of fluvastatin in humans

1996 • 75 citations

‘Targeting’ the epidermal growth factor receptor tyrosine kinase with gefitinib (Iressa®) in non-small cell lung cancer (NSCLC)

2004 • 69 citations

Gefitinib, a novel, orally administered agent for the treatment of cancer

2004 • 68 citations

A sensitive assay for ZD1839 (Iressa) in human plasma by liquid–liquid extraction and high performance liquid chromatography with mass spectrometric detection: validation and use in Phase I clinical trials

2002 • 67 citations

A Clinical Single-Pass Perfusion Investigation of the Dynamic in Vivo Secretory Response to a Dietary Meal in Human Proximal Small Intestine

2006 • 67 citations

Exploring the Relationship Between Expression of Cytochrome P450??Enzymes and Gefitinib Pharmacokinetics

2006 • 65 citations

Relative bioavailability and safety profile of gefitinib administered as a tablet or as a dispersion preparation via drink or nasogastric tube: results of a randomized, open-label, three-period crossover study in healthy volunteers

2004 • 38 citations

A comparison between direct determination of in vivo dissolution and the deconvolution technique in humans

1999 • 34 citations

Direct estimation of the in vivo dissolution of spironolactone, in two particle size ranges, using the single-pass perfusion technique (Loc-I-Gut®) in humans

2001 • 32 citations

A new approach for direct in vivo dissolution studies of poorly soluble drugs.

1997 • 25 citations

Oral drug absorption studies: the best model for man is man!

2001 • 20 citations