Human jejunal permeability of two polar drugs: cimetidine and ranitidine.

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

Regional rectal perfusion: a new in vivo approach to study rectal drug absorption in man.

1995 • 225 citations

The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon

1987 • 207 citations

Predicting fraction dose absorbed in humans using a macroscopic mass balance approach.

1991 • 171 citations

Analysis of models for determining intestinal wall permeabilities

1980 • 106 citations

The Method of Intraluminal Perfusion of the Human Small Intestine

1973 • 97 citations

Determination of intrinsic membrane transport parameters from perfused intestine experiments: A boundary layer approach to estimating the aqueous and unbiased membrane permeabilities

1988 • 93 citations

Human intestinal permeability of piroxicam, propranolol, phenylalanine, and PEG 400 determined by jejunal perfusion.

1997 • 57 citations

A Residence-Time Distribution Analysis of the Hydrodynamics within the Intestine in Man during a Regional Single-pass Perfusion with Loc-I-Gut: In-vivo Permeability Estimation

1997 • 43 citations

Cimetidine absorption and elimination in rat small intestine.

2000 • 39 citations

Simultaneous determination of ranitidine and its metabolites in human plasma and urine by high-performance liquid chromatography

1989 • 30 citations

Pharmacokinetics of cimetidine and its sulphoxide metabolite during haemodialysis

1982 • 26 citations

Intestinal Permeation and Permeability: an Overview

1984 • 17 citations